Cargando…

Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides

[Image: see text] Sesquiterpenes are a rich source of covalent inhibitors with a long history in traditional medicine and include several important therapeutics and tool compounds. Herein, we report the total synthesis of 16 sesquiterpene lactones via a build/couple/pair strategy, including goyasens...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Weilong, Patouret, Rémi, Barluenga, Sofia, Plank, Michael, Loewith, Robbie, Winssinger, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227592/ https://www.ncbi.nlm.nih.gov/pubmed/34235256 http://dx.doi.org/10.1021/acscentsci.1c00056

Ejemplares similares

Acid-Induced Rearrangement of Epoxygermacranolides: Synthesis of Furanoheliangolides and Cadinanes from Nobilin
por: De Mieri, Maria, et al.
Publicado: (2017)

Unravelling the Mode of Action of Furanoheliangolides through Total Synthesis and Chemical Proteomics
por: Hoock, Joseph G. F., et al.
Publicado: (2021)

Pseudo-Complementary G:C Base Pair for Mixed Sequence dsDNA Invasion and Its Applications in Diagnostics (SARS-CoV-2 Detection)
por: López-Tena, Miguel, et al.
Publicado: (2023)

Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9
por: Plank, Michael, et al.
Publicado: (2020)

Combining recombinase polymerase amplification and DNA‐templated reaction for SARS‐CoV‐2 sensing with dual fluorescence and lateral flow assay output
por: Farrera‐Soler, Lluc, et al.
Publicado: (2022)

Antitrypanosomal Activity of Sesquiterpene Lactones from Helianthus tuberosus L. Including a New Furanoheliangolide with an Unusual Structure
por: Galkina, Anna, et al.
Publicado: (2019)

Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma
por: Farrera-Soler, Lluc, et al.
Publicado: (2020)

The structure of importin α and the nuclear localization peptide of ChREBP, and small compound inhibitors of ChREBP–importin α interactions
por: Jung, Hunmin, et al.
Publicado: (2020)

The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse
por: Grad, Iwona, et al.
Publicado: (2010)

DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
por: Daguer, J.-P., et al.
Publicado: (2015)

Importins and exportins in cellular differentiation
por: Okada, Norihisa, et al.
Publicado: (2008)

Regulation of Cellular Metabolism through Phase Separation of Enzymes
por: Prouteau, Manoël, et al.
Publicado: (2018)

High-Throughput Screening to Identify Inhibitors of Plasmodium falciparum Importin α
por: Walunj, Sujata B., et al.
Publicado: (2022)

Xenopus importin beta validates human importin beta as a cell cycle negative regulator
por: Delmar, Valerie A, et al.
Publicado: (2008)

Design and Synthesis of Covalent Inhibitors of FabA
por: Martin, James S., et al.
Publicado: (2023)

Synthesis of Protein-Oligonucleotide Conjugates
por: Watson, Emma E., et al.
Publicado: (2022)

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
por: Loewith, Robbie, et al.
Publicado: (2011)

The molecular basis for the regulation of the CBC by the importins
por: Dias, Sandra M.G., et al.
Publicado: (2009)

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
por: Vazquez‐Rodriguez, Saleta, et al.
Publicado: (2018)

Structural Insights into TOR Signaling
por: Tafur, Lucas, et al.
Publicado: (2020)

Divergent synthesis and identification of the cellular targets of deoxyelephantopins
por: Lagoutte, Roman, et al.
Publicado: (2016)

Nuclear importin α and its physiological importance
por: Miyamoto, Yoichi, et al.
Publicado: (2012)

Importin-beta-like nuclear transport receptors
por: Ström, Anne-Christine, et al.
Publicado: (2001)

Stimulated nuclear import by β-like importins
por: Flores, Karen, et al.
Publicado: (2013)

Importins and Exportins Regulating Allergic Immune Responses
por: Aggarwal, Ankita, et al.
Publicado: (2014)

Co-translational binding of importins to nascent proteins
por: Seidel, Maximilian, et al.
Publicado: (2023)

Distinct mutations in importin-β family nucleocytoplasmic transport receptors transportin-SR and importin-13 affect specific cargo binding
por: Kimura, Makoto, et al.
Publicado: (2021)

Photocaging of Pyridinylimidazole-Based Covalent JNK3 Inhibitors Affords Spatiotemporal Control of the Binding Affinity in Live Cells
por: Hoffelner, Beate Sandra, et al.
Publicado: (2023)

Conservation of Importin α Function in Apicomplexans: Ivermectin and GW5074 Target Plasmodium falciparum Importin α and Inhibit Parasite Growth in Culture
por: Walunj, Sujata B., et al.
Publicado: (2022)

Synthesis of the Novel Covalent Cysteine Proteases Inhibitor with Iodoacetic Functional Group
por: Hartman, Kinga, et al.
Publicado: (2020)

Extensive cargo identification reveals distinct biological roles of the 12 importin pathways
por: Kimura, Makoto, et al.
Publicado: (2017)

Increased expression of importin13 in endometriosis and endometrial carcinoma
por: Zeng, Biao, et al.
Publicado: (2012)

Increased importin 13 activity is associated with the pathogenesis of pterygium
por: Xu, Ke, et al.
Publicado: (2013)

An Importin Code in neuronal transport from synapse-to-nucleus?
por: Lever, Michael B., et al.
Publicado: (2015)

Data on dimer formation between importin α subtypes
por: Miyamoto, Yoichi, et al.
Publicado: (2016)

Importin-11 keeps PTEN safe from harm
por: Leslie, Nick R.
Publicado: (2017)

Importin-11 is Essential for Normal Embryonic Development in Mice
por: Lee, Ju-Young, et al.
Publicado: (2020)

Structure-Function Relationships of Covalent and Non-Covalent BTK Inhibitors
por: Zain, Rula, et al.
Publicado: (2021)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Identification of highly selective covalent inhibitors by phage display
por: Chen, Shiyu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_aqft4iqhui3o7o1itbpfn0ukse