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Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides

[Image: see text] Sesquiterpenes are a rich source of covalent inhibitors with a long history in traditional medicine and include several important therapeutics and tool compounds. Herein, we report the total synthesis of 16 sesquiterpene lactones via a build/couple/pair strategy, including goyasens...

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Detalles Bibliográficos
Autores principales:	Liu, Weilong, Patouret, Rémi, Barluenga, Sofia, Plank, Michael, Loewith, Robbie, Winssinger, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227592/ https://www.ncbi.nlm.nih.gov/pubmed/34235256 http://dx.doi.org/10.1021/acscentsci.1c00056

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