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Biocatalytic Transformations of Silicon—the Other Group 14 Element
[Image: see text] Significant inroads have been made using biocatalysts to perform new-to-nature reactions with high selectivity and efficiency. Meanwhile, advances in organosilicon chemistry have led to rich sets of reactions holding great synthetic value. Merging biocatalysis and silicon chemistry...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227617/ https://www.ncbi.nlm.nih.gov/pubmed/34235255 http://dx.doi.org/10.1021/acscentsci.1c00182 |
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author | Sarai, Nicholas S. Levin, Benjamin J. Roberts, John M. Katsoulis, Dimitris E. Arnold, Frances H. |
author_facet | Sarai, Nicholas S. Levin, Benjamin J. Roberts, John M. Katsoulis, Dimitris E. Arnold, Frances H. |
author_sort | Sarai, Nicholas S. |
collection | PubMed |
description | [Image: see text] Significant inroads have been made using biocatalysts to perform new-to-nature reactions with high selectivity and efficiency. Meanwhile, advances in organosilicon chemistry have led to rich sets of reactions holding great synthetic value. Merging biocatalysis and silicon chemistry could yield new methods for the preparation of valuable organosilicon molecules as well as the degradation and valorization of undesired ones. Despite silicon’s importance in the biosphere for its role in plant and diatom construction, it is not known to be incorporated into any primary or secondary metabolites. Enzymes have been found that act on silicon-containing molecules, but only a few are known to act directly on silicon centers. Protein engineering and evolution has and could continue to enable enzymes to catalyze useful organosilicon transformations, complementing and expanding upon current synthetic methods. The role of silicon in biology and the enzymes that act on silicon-containing molecules are reviewed to set the stage for a discussion of where biocatalysis and organosilicon chemistry may intersect. |
format | Online Article Text |
id | pubmed-8227617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-82276172021-07-06 Biocatalytic Transformations of Silicon—the Other Group 14 Element Sarai, Nicholas S. Levin, Benjamin J. Roberts, John M. Katsoulis, Dimitris E. Arnold, Frances H. ACS Cent Sci [Image: see text] Significant inroads have been made using biocatalysts to perform new-to-nature reactions with high selectivity and efficiency. Meanwhile, advances in organosilicon chemistry have led to rich sets of reactions holding great synthetic value. Merging biocatalysis and silicon chemistry could yield new methods for the preparation of valuable organosilicon molecules as well as the degradation and valorization of undesired ones. Despite silicon’s importance in the biosphere for its role in plant and diatom construction, it is not known to be incorporated into any primary or secondary metabolites. Enzymes have been found that act on silicon-containing molecules, but only a few are known to act directly on silicon centers. Protein engineering and evolution has and could continue to enable enzymes to catalyze useful organosilicon transformations, complementing and expanding upon current synthetic methods. The role of silicon in biology and the enzymes that act on silicon-containing molecules are reviewed to set the stage for a discussion of where biocatalysis and organosilicon chemistry may intersect. American Chemical Society 2021-05-07 2021-06-23 /pmc/articles/PMC8227617/ /pubmed/34235255 http://dx.doi.org/10.1021/acscentsci.1c00182 Text en © 2021 The Authors. Published by American Chemical Society Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Sarai, Nicholas S. Levin, Benjamin J. Roberts, John M. Katsoulis, Dimitris E. Arnold, Frances H. Biocatalytic Transformations of Silicon—the Other Group 14 Element |
title | Biocatalytic Transformations of Silicon—the
Other Group 14 Element |
title_full | Biocatalytic Transformations of Silicon—the
Other Group 14 Element |
title_fullStr | Biocatalytic Transformations of Silicon—the
Other Group 14 Element |
title_full_unstemmed | Biocatalytic Transformations of Silicon—the
Other Group 14 Element |
title_short | Biocatalytic Transformations of Silicon—the
Other Group 14 Element |
title_sort | biocatalytic transformations of silicon—the
other group 14 element |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227617/ https://www.ncbi.nlm.nih.gov/pubmed/34235255 http://dx.doi.org/10.1021/acscentsci.1c00182 |
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