Novel Capsid-Specific Single-Domain Antibodies with Broad Foot-and-Mouth Disease Strain Recognition Reveal Differences in Antigenicity of Virions, Empty Capsids, and Virus-Like Particles

Foot-and-mouth disease (FMD) vaccine efficacy is mainly determined by the content of intact virions (146S) and empty capsids (75S). Both particles may dissociate into 12S subunits upon vaccine manufacturing, formulation, and storage, reducing vaccine potency. We report the isolation of capsid-specif...

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Detalles Bibliográficos
Autores principales: Li, Haozhou, Dekker, Aldo, Sun, Shiqi, Burman, Alison, Kortekaas, Jeroen, Harmsen, Michiel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227720/
https://www.ncbi.nlm.nih.gov/pubmed/34201329
http://dx.doi.org/10.3390/vaccines9060620

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