Cargando…
Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine?
Genetic and environmental factors are involved in the pathogenesis of inflammatory bowel diseases (IBD). The study aimed at investigating the potential influence of single nucleotide polymorphisms (SNPs) NOD2 rs2066844, NOD2 rs2066845, NOD2 rs2066847, IL23R rs11209026, PTPN2 rs2542151, PTPN2 rs72340...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227795/ https://www.ncbi.nlm.nih.gov/pubmed/34198814 http://dx.doi.org/10.3390/genes12060866 |
_version_ | 1783712607146868736 |
---|---|
author | Hoffmann, Peter Lamerz, David Hill, Petra Kirchner, Marietta Gauss, Annika |
author_facet | Hoffmann, Peter Lamerz, David Hill, Petra Kirchner, Marietta Gauss, Annika |
author_sort | Hoffmann, Peter |
collection | PubMed |
description | Genetic and environmental factors are involved in the pathogenesis of inflammatory bowel diseases (IBD). The study aimed at investigating the potential influence of single nucleotide polymorphisms (SNPs) NOD2 rs2066844, NOD2 rs2066845, NOD2 rs2066847, IL23R rs11209026, PTPN2 rs2542151, PTPN2 rs7234029, and ATG16L1 rs2241880 on the response to immunomodulatory therapies and disease course in Crohn’s disease (CD). This is an uncontrolled retrospective monocentric study including patients from the IBD outpatient clinic of Heidelberg University Hospital. Therapy responses and disease courses were related to genetic findings. 379 patients with CD were included. The presence of at least one PTPN2 rs7234029 risk allele was associated with nonresponse to anti-interleukin-12/23 treatment (89.9% vs. 67.6%, p = 0.005). The NOD2 rs2066844 risk allele was associated with a first-degree family history of colon cancer (12.7% vs. 4.7%, p = 0.02), the ATG16L1 rs2241880 risk allele with ileal CD manifestation (p = 0.027), and the IL23R rs11209026 risk allele with a higher rate of CD-related surgeries per disease year (0.08 vs. 0.02, p = 0.025). The results of this study underline the relevance of genetic influences in CD. The association of the PTPN2 rs7234029 risk allele with nonresponse to anti-interleukin-12/23 treatment in CD patients is a novel finding and requires further investigation. |
format | Online Article Text |
id | pubmed-8227795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82277952021-06-26 Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine? Hoffmann, Peter Lamerz, David Hill, Petra Kirchner, Marietta Gauss, Annika Genes (Basel) Article Genetic and environmental factors are involved in the pathogenesis of inflammatory bowel diseases (IBD). The study aimed at investigating the potential influence of single nucleotide polymorphisms (SNPs) NOD2 rs2066844, NOD2 rs2066845, NOD2 rs2066847, IL23R rs11209026, PTPN2 rs2542151, PTPN2 rs7234029, and ATG16L1 rs2241880 on the response to immunomodulatory therapies and disease course in Crohn’s disease (CD). This is an uncontrolled retrospective monocentric study including patients from the IBD outpatient clinic of Heidelberg University Hospital. Therapy responses and disease courses were related to genetic findings. 379 patients with CD were included. The presence of at least one PTPN2 rs7234029 risk allele was associated with nonresponse to anti-interleukin-12/23 treatment (89.9% vs. 67.6%, p = 0.005). The NOD2 rs2066844 risk allele was associated with a first-degree family history of colon cancer (12.7% vs. 4.7%, p = 0.02), the ATG16L1 rs2241880 risk allele with ileal CD manifestation (p = 0.027), and the IL23R rs11209026 risk allele with a higher rate of CD-related surgeries per disease year (0.08 vs. 0.02, p = 0.025). The results of this study underline the relevance of genetic influences in CD. The association of the PTPN2 rs7234029 risk allele with nonresponse to anti-interleukin-12/23 treatment in CD patients is a novel finding and requires further investigation. MDPI 2021-06-05 /pmc/articles/PMC8227795/ /pubmed/34198814 http://dx.doi.org/10.3390/genes12060866 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hoffmann, Peter Lamerz, David Hill, Petra Kirchner, Marietta Gauss, Annika Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine? |
title | Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine? |
title_full | Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine? |
title_fullStr | Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine? |
title_full_unstemmed | Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine? |
title_short | Gene Polymorphisms of NOD2, IL23R, PTPN2 and ATG16L1 in Patients with Crohn’s Disease: On the Way to Personalized Medicine? |
title_sort | gene polymorphisms of nod2, il23r, ptpn2 and atg16l1 in patients with crohn’s disease: on the way to personalized medicine? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227795/ https://www.ncbi.nlm.nih.gov/pubmed/34198814 http://dx.doi.org/10.3390/genes12060866 |
work_keys_str_mv | AT hoffmannpeter genepolymorphismsofnod2il23rptpn2andatg16l1inpatientswithcrohnsdiseaseonthewaytopersonalizedmedicine AT lamerzdavid genepolymorphismsofnod2il23rptpn2andatg16l1inpatientswithcrohnsdiseaseonthewaytopersonalizedmedicine AT hillpetra genepolymorphismsofnod2il23rptpn2andatg16l1inpatientswithcrohnsdiseaseonthewaytopersonalizedmedicine AT kirchnermarietta genepolymorphismsofnod2il23rptpn2andatg16l1inpatientswithcrohnsdiseaseonthewaytopersonalizedmedicine AT gaussannika genepolymorphismsofnod2il23rptpn2andatg16l1inpatientswithcrohnsdiseaseonthewaytopersonalizedmedicine |