Cargando…

Targeting the Proteasome in Advanced Renal Cell Carcinoma: Complexity and Limitations of Patient-Individualized Preclinical Drug Discovery

Background: Systemic treatment options for metastatic renal cell carcinoma (RCC) have significantly expanded in recent years. However, patients refractory to tyrosine kinase and immune checkpoint inhibitors still have limited treatment options and patient-individualized approaches are largely missin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jielin, Pohl, Laura, Schüler, Julia, Korzeniewski, Nina, Reimold, Philipp, Kaczorowski, Adam, Hou, Weibin, Zschäbitz, Stefanie, Nientiedt, Cathleen, Jäger, Dirk, Hohenfellner, Markus, Duensing, Anette, Duensing, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227814/ https://www.ncbi.nlm.nih.gov/pubmed/34072926 http://dx.doi.org/10.3390/biomedicines9060627

Ejemplares similares

Mutations in BRCA2 and taxane resistance in prostate cancer
por: Nientiedt, Cathleen, et al.
Publicado: (2017)

Digital Spatial Profiling Identifies the Tumor Periphery as a Highly Active Biological Niche in Clear Cell Renal Cell Carcinoma
por: Schneider, Felix, et al.
Publicado: (2023)

The BRCA2 mutation status shapes the immune phenotype of prostate cancer
por: Jenzer, Maximilian, et al.
Publicado: (2019)

Kidney Cancer Models for Pre-Clinical Drug Discovery: Challenges and Opportunities
por: Pohl, Laura, et al.
Publicado: (2022)

BAP1 and PTEN mutations shape the immunological landscape of clear cell renal cell carcinoma and reveal the intertumoral heterogeneity of T cell suppression: a proof-of-concept study
por: Friedhoff, Jana, et al.
Publicado: (2022)

Daughter Centriole Elongation Is Controlled by Proteolysis
por: Korzeniewski, Nina, et al.
Publicado: (2010)

Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stability
por: Tapia-Laliena, María Ángeles, et al.
Publicado: (2019)

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention
por: Korzeniewski, Nina, et al.
Publicado: (2010)

Senescent Tumor Cells Are Frequently Present at the Invasion Front: Implications for Improving Disease Control in Patients with Locally Advanced Prostate Cancer
por: Schwarz, Sebastian, et al.
Publicado: (2023)

Efficacy of Cabazitaxel Treatment in Metastatic Castration Resistant Prostate Cancer in Second and Later Lines. An Experience from Two German Centers
por: Zschäbitz, Stefanie, et al.
Publicado: (2017)

Prospective single center trial of next-generation sequencing analysis in metastatic renal cell cancer: the MORE-TRIAL
por: Dieffenbacher, Svenja, et al.
Publicado: (2018)

Publisher Correction: Detection of PD-L1 in the urine of patients with urothelial carcinoma of the bladder
por: Tosev, Georgi, et al.
Publicado: (2021)

Detection of PD-L1 in the urine of patients with urothelial carcinoma of the bladder
por: Tosev, Georgi, et al.
Publicado: (2021)

The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression
por: Korzeniewski, Nina, et al.
Publicado: (2011)

Efficacy and Safety of Checkpoint Inhibitor Treatment in Patients with Advanced Renal or Urothelial Cell Carcinoma and Concomitant Chronic Kidney Disease: A Retrospective Cohort Study
por: Seydel, Florian, et al.
Publicado: (2021)

Bortezomib: killing two birds with one stone in gastrointestinal stromal tumors
por: Duensing, Stefan, et al.
Publicado: (2010)

Evolution of Salvage Radical Prostatectomy from Open to Robotic and Further to Retzius Sparing Surgery
por: Schuetz, Viktoria, et al.
Publicado: (2021)

Genomic features of renal cell carcinoma with venous tumor thrombus
por: Warsow, Gregor, et al.
Publicado: (2018)

Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
por: Hoefflin, Rouven, et al.
Publicado: (2016)

Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis
por: Liu, Ying, et al.
Publicado: (2008)

miR-449a Repression Leads to Enhanced NOTCH Signaling in TMPRSS2:ERG Fusion Positive Prostate Cancer Cells
por: Bauer, Simone, et al.
Publicado: (2021)

Impact of Surgeon’s Experience in Rigid versus Elastic MRI/TRUS-Fusion Biopsy to Detect Significant Prostate Cancer Using Targeted and Systematic Cores
por: Görtz, Magdalena, et al.
Publicado: (2022)

Gamma-tubulin and 53BP1 as candidate biomarkers of human papillomavirus-associated anal dysplasia
por: Ho, Ken S, et al.
Publicado: (2010)

Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma — Prognostic and Translational Implications()
por: Zhou, Xiaoguang, et al.
Publicado: (2015)

Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma()
por: Zhou, Xiaoguang, et al.
Publicado: (2014)

An artificial intelligence-based chatbot for prostate cancer education: Design and patient evaluation study
por: Görtz, Magdalena, et al.
Publicado: (2023)

The ribosomal protein S6 in renal cell carcinoma: functional relevance and potential as biomarker
por: Knoll, Maximilian, et al.
Publicado: (2015)

Prognostic Significance and Functional Role of CEP57 in Prostate Cancer()
por: Mang, Josef, et al.
Publicado: (2015)

Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy
por: Dietz, Steffen, et al.
Publicado: (2017)

Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate
por: Apostolidis, Leonidas, et al.
Publicado: (2019)

Hydronephrotic pelvic kidney mimicking urinary retention in an 18-year-old male
por: Reimold, Philipp, et al.
Publicado: (2022)

Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells
por: Rausch, Jessica L., et al.
Publicado: (2020)

Survival outcomes of patients with germ cell tumors treated with high-dose chemotherapy for refractory or relapsing disease
por: Zschäbitz, Stefanie, et al.
Publicado: (2018)

Fracture of a 40-mm BIOLOX Delta Femoral Head
por: Duensing, Ian M., et al.
Publicado: (2021)

Prognostic impact of in vivo soluble cell adhesion molecules in metastatic renal cell carcinoma
por: Hoffmann, R, et al.
Publicado: (1999)

Arthroscopic Femoral Osteochondroplasty for Cam-type Femoroacetabular Impingement: Cortical–Cancellous Sclerotic Boundary Guides Resection Depth
por: Mortensen, Alexander J., et al.
Publicado: (2020)

Disassociation of a Cold-Welded Bimodular Titanium Femoral Stem by Intraoperative Ice Cooling
por: Frandsen, Jeff, et al.
Publicado: (2020)

Ago-RIP-Seq identifies Polycomb repressive complex I member CBX7 as a major target of miR-375 in prostate cancer progression
por: Pickl, Julia M.A., et al.
Publicado: (2016)

A Platform and Multisided Market for Translational, Software-Defined Medical Procedures in the Operating Room (OP 4.1): Proof-of-Concept Study
por: Görtz, Magdalena, et al.
Publicado: (2022)

Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy
por: Boccadoro, Mario, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_cko3g48i580hasnb275r4odv9f