Human Keratinocytes Inhibit CD4(+) T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints

Human skin protects the body against infection and injury. This protection involves immune and epithelial cells, but their interactions remain largely unknown. Here, we show that cultured epidermal keratinocytes inhibit allogenic CD4(+) T-cell proliferation under both normal and inflammatory conditi...

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Detalles Bibliográficos
Autores principales: Mestrallet, Guillaume, Auvré, Frédéric, Schenowitz, Chantal, Carosella, Edgardo D., LeMaoult, Joel, Martin, Michèle T., Rouas-Freiss, Nathalie, Fortunel, Nicolas O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227977/
https://www.ncbi.nlm.nih.gov/pubmed/34201301
http://dx.doi.org/10.3390/cells10061438

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