Cargando…

The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of Disease

Necroptosis is an inflammatory form of lytic programmed cell death that is thought to have evolved to defend against pathogens. Genetic deletion of the terminal effector protein—MLKL—shows no overt phenotype in the C57BL/6 mouse strain under conventional laboratory housing conditions. Small molecule...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tovey Crutchfield, Emma C., Garnish, Sarah E., Hildebrand, Joanne M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227991/ https://www.ncbi.nlm.nih.gov/pubmed/34071602 http://dx.doi.org/10.3390/biom11060803

Ejemplares similares

Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway
por: Garnish, Sarah E., et al.
Publicado: (2022)

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
por: Jacobsen, A V, et al.
Publicado: (2016)

Post-translational control of RIPK3 and MLKL mediated necroptotic cell death
por: Murphy, James M., et al.
Publicado: (2015)

Inhibition of MLKL Attenuates Necroptotic Cell Death in a Murine Cell Model of Hepatic Ischaemia Injury
por: Baidya, Raji, et al.
Publicado: (2021)

Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death
por: Arnež, Katja Hrovat, et al.
Publicado: (2016)

Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains
por: Taslimi, Amir, et al.
Publicado: (2022)

A Putative Serine Protease is Required to Initiate the RIPK3-MLKL—Mediated Necroptotic Death Pathway in Neutrophils
por: Wang, Xiaoliang, et al.
Publicado: (2021)

MLKL deficiency protects against low-grade, sterile inflammation in aged mice
por: Tovey Crutchfield, Emma C., et al.
Publicado: (2023)

A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression
por: Dai, Jialin, et al.
Publicado: (2020)

RIPK3–MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis
por: Zhang, Xufei, et al.
Publicado: (2023)

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis
por: Moujalled, Diane, et al.
Publicado: (2021)

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
por: Garnish, Sarah E., et al.
Publicado: (2021)

Key roles of necroptotic factors in promoting tumor growth
por: Liu, Xinjian, et al.
Publicado: (2016)

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
por: Garnish, Sarah E., et al.
Publicado: (2023)

ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation
por: Yang, Yuanqin, et al.
Publicado: (2021)

Role of mitochondria in apoptotic and necroptotic cell death in the developing brain
por: Thornton, Claire, et al.
Publicado: (2015)

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
por: Meng, Yanxiang, et al.
Publicado: (2021)

Flicking the molecular switch underlying MLKL-mediated necroptosis
por: Hildebrand, Joanne M, et al.
Publicado: (2015)

Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization
por: Meng, Yanxiang, et al.
Publicado: (2023)

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
por: Samson, Andre L., et al.
Publicado: (2020)

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
por: Wu, Jianfeng, et al.
Publicado: (2013)

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
por: Petrie, Emma J., et al.
Publicado: (2018)

Exploding the necroptotic bubble
por: Edry-Botzer, Liat, et al.
Publicado: (2017)

Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective
por: Shi, Shaojun, et al.
Publicado: (2019)

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted
por: Stutz, Michael D., et al.
Publicado: (2017)

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
por: de Almagro, M Cristina, et al.
Publicado: (2017)

Necroptotic Cell Death Promotes Adaptive Immunity Against Colonizing Pneumococci
por: Riegler, Ashleigh Nichole, et al.
Publicado: (2019)

Cartilage Trauma Induces Necroptotic Chondrocyte Death and Expulsion of Cellular Contents
por: Stolberg-Stolberg, Josef, et al.
Publicado: (2020)

The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis
por: Li, Lu, et al.
Publicado: (2020)

Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine’s inhibitory effects on necroptotic kinases
por: Zeb, Salman, et al.
Publicado: (2023)

Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice
por: Belizário, José, et al.
Publicado: (2015)

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
por: Davies, Katherine A., et al.
Publicado: (2020)

Cytoplasmic MYC is an anti-necroptotic protein
por: Lee, Eun-Woo, et al.
Publicado: (2020)

Proteomic analysis of necroptotic extracellular vesicles
por: Shlomovitz, Inbar, et al.
Publicado: (2021)

Acute Myeloid Leukemia-Targeted Toxin Activates Both Apoptotic and Necroptotic Death Mechanisms
por: Horita, Henrick, et al.
Publicado: (2008)

Gallic Acid Triggers Iron-Dependent Cell Death with Apoptotic, Ferroptotic, and Necroptotic Features
por: Tang, Ho Man, et al.
Publicado: (2019)

Recapitulating Cholangiopathy-Associated Necroptotic Cell Death In Vitro Using Human Cholangiocyte Organoids
por: Shi, Shaojun, et al.
Publicado: (2021)

Suppression of the necroptotic cell death pathways improves survival in Smn(2B/−) mice
por: Chehade, Lucia, et al.
Publicado: (2022)

A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes
por: Hildebrand, Joanne M., et al.
Publicado: (2021)

Examination of the role of necroptotic damage-associated molecular patterns in tissue fibrosis
por: Liu, Xu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vo1f3848cnl0cd0d17d6m55mpb