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ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country
Hereditary transthyretin amyloidosis (ATTRv, v for variant) prevalence in Italy, a non-endemic region, has been established by ATTRv amyloidosis Italian Registry. However, values of prevalence were extremely heterogeneous, considering different regions. To properly establish the prevalence of the di...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228008/ https://www.ncbi.nlm.nih.gov/pubmed/34071271 http://dx.doi.org/10.3390/genes12060829 |
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author | Luigetti, Marco Guglielmino, Valeria Antonini, Giovanni Casali, Carlo Ceccanti, Marco Chiappini, Maria Grazia De Giglio, Laura Di Lazzaro, Vincenzo Di Muzio, Antonio Goglia, Mariangela Inghilleri, Maurizio Leonardi, Luca Massa, Roberto Pennisi, Elena Maria Petrucci, Antonio Proietti, Emanuela Rispoli, Marianna Sabatelli, Mario Di Girolamo, Marco |
author_facet | Luigetti, Marco Guglielmino, Valeria Antonini, Giovanni Casali, Carlo Ceccanti, Marco Chiappini, Maria Grazia De Giglio, Laura Di Lazzaro, Vincenzo Di Muzio, Antonio Goglia, Mariangela Inghilleri, Maurizio Leonardi, Luca Massa, Roberto Pennisi, Elena Maria Petrucci, Antonio Proietti, Emanuela Rispoli, Marianna Sabatelli, Mario Di Girolamo, Marco |
author_sort | Luigetti, Marco |
collection | PubMed |
description | Hereditary transthyretin amyloidosis (ATTRv, v for variant) prevalence in Italy, a non-endemic region, has been established by ATTRv amyloidosis Italian Registry. However, values of prevalence were extremely heterogeneous, considering different regions. To properly establish the prevalence of the disease in the Lazio region, a survey was sent to university regional hospitals and to main regional hospitals, in order to collect all affected patients regularly followed. We identified 100 ATTRv patients and, considering a Lazio population of 5.8/million, we estimated a ATTRv prevalence of 17.2/million. The ATTRv amyloidosis Italian Registry reported a prevalence of 8.0/million in Lazio, while our survey showed a value of double this. Our survey documented a high-prevalence for a non-endemic country. The increased awareness of the disease among general practitioners and medical specialists is a fundamental step to reduce the diagnostic delay and start an effective treatment of this disease. |
format | Online Article Text |
id | pubmed-8228008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82280082021-06-26 ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country Luigetti, Marco Guglielmino, Valeria Antonini, Giovanni Casali, Carlo Ceccanti, Marco Chiappini, Maria Grazia De Giglio, Laura Di Lazzaro, Vincenzo Di Muzio, Antonio Goglia, Mariangela Inghilleri, Maurizio Leonardi, Luca Massa, Roberto Pennisi, Elena Maria Petrucci, Antonio Proietti, Emanuela Rispoli, Marianna Sabatelli, Mario Di Girolamo, Marco Genes (Basel) Brief Report Hereditary transthyretin amyloidosis (ATTRv, v for variant) prevalence in Italy, a non-endemic region, has been established by ATTRv amyloidosis Italian Registry. However, values of prevalence were extremely heterogeneous, considering different regions. To properly establish the prevalence of the disease in the Lazio region, a survey was sent to university regional hospitals and to main regional hospitals, in order to collect all affected patients regularly followed. We identified 100 ATTRv patients and, considering a Lazio population of 5.8/million, we estimated a ATTRv prevalence of 17.2/million. The ATTRv amyloidosis Italian Registry reported a prevalence of 8.0/million in Lazio, while our survey showed a value of double this. Our survey documented a high-prevalence for a non-endemic country. The increased awareness of the disease among general practitioners and medical specialists is a fundamental step to reduce the diagnostic delay and start an effective treatment of this disease. MDPI 2021-05-28 /pmc/articles/PMC8228008/ /pubmed/34071271 http://dx.doi.org/10.3390/genes12060829 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Luigetti, Marco Guglielmino, Valeria Antonini, Giovanni Casali, Carlo Ceccanti, Marco Chiappini, Maria Grazia De Giglio, Laura Di Lazzaro, Vincenzo Di Muzio, Antonio Goglia, Mariangela Inghilleri, Maurizio Leonardi, Luca Massa, Roberto Pennisi, Elena Maria Petrucci, Antonio Proietti, Emanuela Rispoli, Marianna Sabatelli, Mario Di Girolamo, Marco ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country |
title | ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country |
title_full | ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country |
title_fullStr | ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country |
title_full_unstemmed | ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country |
title_short | ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country |
title_sort | attrv in lazio-italy: a high-prevalence region in a non-endemic country |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228008/ https://www.ncbi.nlm.nih.gov/pubmed/34071271 http://dx.doi.org/10.3390/genes12060829 |
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