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At-Line Reversed Phase Liquid Chromatography for In-Process Monitoring of Inclusion Body Solubilization

Refolding is known as the bottleneck in inclusion body (IB) downstream processing in the pharmaceutical industry: high dilutions leading to large operating volumes, slow refolding kinetics and low refolding yields are only a few of the problems that impede industrial application. Solubilization prio...

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Detalles Bibliográficos
Autores principales:	Ebner, Julian, Humer, Diana, Klausser, Robert, Rubus, Viktor, Pell, Reinhard, Spadiut, Oliver, Kopp, Julian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228044/ https://www.ncbi.nlm.nih.gov/pubmed/34200471 http://dx.doi.org/10.3390/bioengineering8060078

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