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Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis

Background and Objectives: Brain organoids are self-assembled, three-dimensional (3D) aggregates generated from pluripotent stem cells. These models are useful for experimental studies on human brain development and function and are therefore increasingly used for research worldwide. As their increa...

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Autores principales: Ide, Kazuki, Matsuoka, Norihiro, Fujita, Misao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228092/
https://www.ncbi.nlm.nih.gov/pubmed/34071749
http://dx.doi.org/10.3390/medicina57060532
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author Ide, Kazuki
Matsuoka, Norihiro
Fujita, Misao
author_facet Ide, Kazuki
Matsuoka, Norihiro
Fujita, Misao
author_sort Ide, Kazuki
collection PubMed
description Background and Objectives: Brain organoids are self-assembled, three-dimensional (3D) aggregates generated from pluripotent stem cells. These models are useful for experimental studies on human brain development and function and are therefore increasingly used for research worldwide. As their increasing use raises several ethical questions, we aimed to assess the current state of the press on brain organoid research using a cross-sectional database to understand the extent of discussion of this subject in the public. Materials and Methods: We conducted a descriptive analysis of news reports obtained from the Nexis Uni database, searched in April 2020. After extracting the news reports, the number of published reports in each year and the included terms were analyzed. Results: Up to April 2020, 332 news reports had been published, with over half of them published in the United States and the United Kingdom, with the numbers gradually increasing every year. In total, 113 (34.0%) news reports included ethics-related keywords, and the ratio of studies before and after the study-period midpoint was significantly increased (21.0% (2013–2016) vs. 38.2% (2017–2020); p = 0.0066, Chi-square test with Yates’ continuity correction). Conclusions: Although news reports on the ethical aspects of brain organoid research have been increasing gradually, there was a bias in the region of publication. Additional studies focusing on the ethical aspects of brain organoid research should strive to assess the public perception on the subject in different parts of the world.
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spelling pubmed-82280922021-06-26 Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis Ide, Kazuki Matsuoka, Norihiro Fujita, Misao Medicina (Kaunas) Article Background and Objectives: Brain organoids are self-assembled, three-dimensional (3D) aggregates generated from pluripotent stem cells. These models are useful for experimental studies on human brain development and function and are therefore increasingly used for research worldwide. As their increasing use raises several ethical questions, we aimed to assess the current state of the press on brain organoid research using a cross-sectional database to understand the extent of discussion of this subject in the public. Materials and Methods: We conducted a descriptive analysis of news reports obtained from the Nexis Uni database, searched in April 2020. After extracting the news reports, the number of published reports in each year and the included terms were analyzed. Results: Up to April 2020, 332 news reports had been published, with over half of them published in the United States and the United Kingdom, with the numbers gradually increasing every year. In total, 113 (34.0%) news reports included ethics-related keywords, and the ratio of studies before and after the study-period midpoint was significantly increased (21.0% (2013–2016) vs. 38.2% (2017–2020); p = 0.0066, Chi-square test with Yates’ continuity correction). Conclusions: Although news reports on the ethical aspects of brain organoid research have been increasing gradually, there was a bias in the region of publication. Additional studies focusing on the ethical aspects of brain organoid research should strive to assess the public perception on the subject in different parts of the world. MDPI 2021-05-27 /pmc/articles/PMC8228092/ /pubmed/34071749 http://dx.doi.org/10.3390/medicina57060532 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ide, Kazuki
Matsuoka, Norihiro
Fujita, Misao
Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis
title Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis
title_full Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis
title_fullStr Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis
title_full_unstemmed Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis
title_short Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis
title_sort ethical aspects of brain organoid research in news reports: an exploratory descriptive analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228092/
https://www.ncbi.nlm.nih.gov/pubmed/34071749
http://dx.doi.org/10.3390/medicina57060532
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