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COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation

Patients with underlying cardiovascular conditions are particularly vulnerable to severe COVID-19. In this project, we aimed to characterize similarities in dysregulated immune pathways between COVID-19 patients and patients with cardiomyopathy, venous thromboembolism (VTE), or coronary artery disea...

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Autores principales: Lee, Abby C., Castaneda, Grant, Li, Wei Tse, Chen, Chengyu, Shende, Neil, Chakladar, Jaideep, Taub, Pam R., Chang, Eric Y., Ongkeko, Weg M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228164/
https://www.ncbi.nlm.nih.gov/pubmed/34071557
http://dx.doi.org/10.3390/v13061018
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author Lee, Abby C.
Castaneda, Grant
Li, Wei Tse
Chen, Chengyu
Shende, Neil
Chakladar, Jaideep
Taub, Pam R.
Chang, Eric Y.
Ongkeko, Weg M.
author_facet Lee, Abby C.
Castaneda, Grant
Li, Wei Tse
Chen, Chengyu
Shende, Neil
Chakladar, Jaideep
Taub, Pam R.
Chang, Eric Y.
Ongkeko, Weg M.
author_sort Lee, Abby C.
collection PubMed
description Patients with underlying cardiovascular conditions are particularly vulnerable to severe COVID-19. In this project, we aimed to characterize similarities in dysregulated immune pathways between COVID-19 patients and patients with cardiomyopathy, venous thromboembolism (VTE), or coronary artery disease (CAD). We hypothesized that these similarly dysregulated pathways may be critical to how cardiovascular diseases (CVDs) exacerbate COVID-19. To evaluate immune dysregulation in different diseases, we used four separate datasets, including RNA-sequencing data from human left ventricular cardiac muscle samples of patients with dilated or ischemic cardiomyopathy and healthy controls; RNA-sequencing data of whole blood samples from patients with single or recurrent event VTE and healthy controls; RNA-sequencing data of human peripheral blood mononuclear cells (PBMCs) from patients with and without obstructive CAD; and RNA-sequencing data of platelets from COVID-19 subjects and healthy controls. We found similar immune dysregulation profiles between patients with CVDs and COVID-19 patients. Interestingly, cardiomyopathy patients display the most similar immune landscape to COVID-19 patients. Additionally, COVID-19 patients experience greater upregulation of cytokine- and inflammasome-related genes than patients with CVDs. In all, patients with CVDs have a significant overlap of cytokine- and inflammasome-related gene expression profiles with that of COVID-19 patients, possibly explaining their greater vulnerability to severe COVID-19.
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spelling pubmed-82281642021-06-26 COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation Lee, Abby C. Castaneda, Grant Li, Wei Tse Chen, Chengyu Shende, Neil Chakladar, Jaideep Taub, Pam R. Chang, Eric Y. Ongkeko, Weg M. Viruses Article Patients with underlying cardiovascular conditions are particularly vulnerable to severe COVID-19. In this project, we aimed to characterize similarities in dysregulated immune pathways between COVID-19 patients and patients with cardiomyopathy, venous thromboembolism (VTE), or coronary artery disease (CAD). We hypothesized that these similarly dysregulated pathways may be critical to how cardiovascular diseases (CVDs) exacerbate COVID-19. To evaluate immune dysregulation in different diseases, we used four separate datasets, including RNA-sequencing data from human left ventricular cardiac muscle samples of patients with dilated or ischemic cardiomyopathy and healthy controls; RNA-sequencing data of whole blood samples from patients with single or recurrent event VTE and healthy controls; RNA-sequencing data of human peripheral blood mononuclear cells (PBMCs) from patients with and without obstructive CAD; and RNA-sequencing data of platelets from COVID-19 subjects and healthy controls. We found similar immune dysregulation profiles between patients with CVDs and COVID-19 patients. Interestingly, cardiomyopathy patients display the most similar immune landscape to COVID-19 patients. Additionally, COVID-19 patients experience greater upregulation of cytokine- and inflammasome-related genes than patients with CVDs. In all, patients with CVDs have a significant overlap of cytokine- and inflammasome-related gene expression profiles with that of COVID-19 patients, possibly explaining their greater vulnerability to severe COVID-19. MDPI 2021-05-28 /pmc/articles/PMC8228164/ /pubmed/34071557 http://dx.doi.org/10.3390/v13061018 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Abby C.
Castaneda, Grant
Li, Wei Tse
Chen, Chengyu
Shende, Neil
Chakladar, Jaideep
Taub, Pam R.
Chang, Eric Y.
Ongkeko, Weg M.
COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation
title COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation
title_full COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation
title_fullStr COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation
title_full_unstemmed COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation
title_short COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation
title_sort covid-19 severity potentially modulated by cardiovascular-disease-associated immune dysregulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228164/
https://www.ncbi.nlm.nih.gov/pubmed/34071557
http://dx.doi.org/10.3390/v13061018
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