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Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial

Background: Between 20–50% of patients undergoing maintenance dialysis for end-stage kidney disease experience symptoms of depression and/or anxiety, associated with increased mortality, greater health care utilization, and decreased quality of life. It is unknown whether mindfulness-based intervent...

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Autores principales: Nassim, Marouane, Park, Haley, Dikaios, Elena, Potes, Angela, Elbaz, Sasha, Mc Veigh, Clare, Lipman, Mark, Novak, Marta, Trinh, Emilie, Alam, Ahsan, Suri, Rita S., Thomas, Zoe, Torres-Platas, Susana, Vasudev, Akshya, Sasi, Neeti, Gautier, Maryse, Mucsi, Istvan, Noble, Helen, Rej, Soham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228217/
https://www.ncbi.nlm.nih.gov/pubmed/34205915
http://dx.doi.org/10.3390/healthcare9060659
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author Nassim, Marouane
Park, Haley
Dikaios, Elena
Potes, Angela
Elbaz, Sasha
Mc Veigh, Clare
Lipman, Mark
Novak, Marta
Trinh, Emilie
Alam, Ahsan
Suri, Rita S.
Thomas, Zoe
Torres-Platas, Susana
Vasudev, Akshya
Sasi, Neeti
Gautier, Maryse
Mucsi, Istvan
Noble, Helen
Rej, Soham
author_facet Nassim, Marouane
Park, Haley
Dikaios, Elena
Potes, Angela
Elbaz, Sasha
Mc Veigh, Clare
Lipman, Mark
Novak, Marta
Trinh, Emilie
Alam, Ahsan
Suri, Rita S.
Thomas, Zoe
Torres-Platas, Susana
Vasudev, Akshya
Sasi, Neeti
Gautier, Maryse
Mucsi, Istvan
Noble, Helen
Rej, Soham
author_sort Nassim, Marouane
collection PubMed
description Background: Between 20–50% of patients undergoing maintenance dialysis for end-stage kidney disease experience symptoms of depression and/or anxiety, associated with increased mortality, greater health care utilization, and decreased quality of life. It is unknown whether mindfulness-based interventions can improve depression and anxiety symptoms in patients receiving this treatment. Methods: We conducted an 8-week multicenter randomized controlled trial comparing a brief mindfulness intervention (BMI) vs. an active control (Health Enhancement Program [HEP]) in 55 patients receiving dialysis with symptoms of depression and/or anxiety. The primary outcome was change in Patient Health Questionnaire-9 (PHQ-9) depression scores, with a primary analysis in participants with baseline PHQ-9 ≥ 10, and a secondary analysis including all participants. The secondary outcome was change in Generalized Anxiety Disorder-7 (GAD-7) anxiety scores with corresponding primary and secondary analyses. Results: Both BMI and HEP reduced depressive symptoms, with no difference between trial arms (PHQ-9 change = −7.0 vs. −6.1, p = 0.62). BMI was more effective than HEP in reducing anxiety (GAD-7 change = −8.7 vs. −1.4, p = 0.01). Secondary analyses revealed no differences between arms. Conclusions: For patients undergoing dialysis, both BMI and HEP may be helpful interventions for depression symptoms, and BMI may be superior to HEP for anxiety symptoms. Mindfulness-based and other psychosocial interventions may be further evaluated in those undergoing dialysis as treatment options for symptoms of depression and anxiety.
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spelling pubmed-82282172021-06-26 Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial Nassim, Marouane Park, Haley Dikaios, Elena Potes, Angela Elbaz, Sasha Mc Veigh, Clare Lipman, Mark Novak, Marta Trinh, Emilie Alam, Ahsan Suri, Rita S. Thomas, Zoe Torres-Platas, Susana Vasudev, Akshya Sasi, Neeti Gautier, Maryse Mucsi, Istvan Noble, Helen Rej, Soham Healthcare (Basel) Article Background: Between 20–50% of patients undergoing maintenance dialysis for end-stage kidney disease experience symptoms of depression and/or anxiety, associated with increased mortality, greater health care utilization, and decreased quality of life. It is unknown whether mindfulness-based interventions can improve depression and anxiety symptoms in patients receiving this treatment. Methods: We conducted an 8-week multicenter randomized controlled trial comparing a brief mindfulness intervention (BMI) vs. an active control (Health Enhancement Program [HEP]) in 55 patients receiving dialysis with symptoms of depression and/or anxiety. The primary outcome was change in Patient Health Questionnaire-9 (PHQ-9) depression scores, with a primary analysis in participants with baseline PHQ-9 ≥ 10, and a secondary analysis including all participants. The secondary outcome was change in Generalized Anxiety Disorder-7 (GAD-7) anxiety scores with corresponding primary and secondary analyses. Results: Both BMI and HEP reduced depressive symptoms, with no difference between trial arms (PHQ-9 change = −7.0 vs. −6.1, p = 0.62). BMI was more effective than HEP in reducing anxiety (GAD-7 change = −8.7 vs. −1.4, p = 0.01). Secondary analyses revealed no differences between arms. Conclusions: For patients undergoing dialysis, both BMI and HEP may be helpful interventions for depression symptoms, and BMI may be superior to HEP for anxiety symptoms. Mindfulness-based and other psychosocial interventions may be further evaluated in those undergoing dialysis as treatment options for symptoms of depression and anxiety. MDPI 2021-06-01 /pmc/articles/PMC8228217/ /pubmed/34205915 http://dx.doi.org/10.3390/healthcare9060659 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nassim, Marouane
Park, Haley
Dikaios, Elena
Potes, Angela
Elbaz, Sasha
Mc Veigh, Clare
Lipman, Mark
Novak, Marta
Trinh, Emilie
Alam, Ahsan
Suri, Rita S.
Thomas, Zoe
Torres-Platas, Susana
Vasudev, Akshya
Sasi, Neeti
Gautier, Maryse
Mucsi, Istvan
Noble, Helen
Rej, Soham
Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
title Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
title_full Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
title_fullStr Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
title_full_unstemmed Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
title_short Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
title_sort brief mindfulness intervention vs. health enhancement program for patients undergoing dialysis: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228217/
https://www.ncbi.nlm.nih.gov/pubmed/34205915
http://dx.doi.org/10.3390/healthcare9060659
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