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Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial
Background: Between 20–50% of patients undergoing maintenance dialysis for end-stage kidney disease experience symptoms of depression and/or anxiety, associated with increased mortality, greater health care utilization, and decreased quality of life. It is unknown whether mindfulness-based intervent...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228217/ https://www.ncbi.nlm.nih.gov/pubmed/34205915 http://dx.doi.org/10.3390/healthcare9060659 |
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author | Nassim, Marouane Park, Haley Dikaios, Elena Potes, Angela Elbaz, Sasha Mc Veigh, Clare Lipman, Mark Novak, Marta Trinh, Emilie Alam, Ahsan Suri, Rita S. Thomas, Zoe Torres-Platas, Susana Vasudev, Akshya Sasi, Neeti Gautier, Maryse Mucsi, Istvan Noble, Helen Rej, Soham |
author_facet | Nassim, Marouane Park, Haley Dikaios, Elena Potes, Angela Elbaz, Sasha Mc Veigh, Clare Lipman, Mark Novak, Marta Trinh, Emilie Alam, Ahsan Suri, Rita S. Thomas, Zoe Torres-Platas, Susana Vasudev, Akshya Sasi, Neeti Gautier, Maryse Mucsi, Istvan Noble, Helen Rej, Soham |
author_sort | Nassim, Marouane |
collection | PubMed |
description | Background: Between 20–50% of patients undergoing maintenance dialysis for end-stage kidney disease experience symptoms of depression and/or anxiety, associated with increased mortality, greater health care utilization, and decreased quality of life. It is unknown whether mindfulness-based interventions can improve depression and anxiety symptoms in patients receiving this treatment. Methods: We conducted an 8-week multicenter randomized controlled trial comparing a brief mindfulness intervention (BMI) vs. an active control (Health Enhancement Program [HEP]) in 55 patients receiving dialysis with symptoms of depression and/or anxiety. The primary outcome was change in Patient Health Questionnaire-9 (PHQ-9) depression scores, with a primary analysis in participants with baseline PHQ-9 ≥ 10, and a secondary analysis including all participants. The secondary outcome was change in Generalized Anxiety Disorder-7 (GAD-7) anxiety scores with corresponding primary and secondary analyses. Results: Both BMI and HEP reduced depressive symptoms, with no difference between trial arms (PHQ-9 change = −7.0 vs. −6.1, p = 0.62). BMI was more effective than HEP in reducing anxiety (GAD-7 change = −8.7 vs. −1.4, p = 0.01). Secondary analyses revealed no differences between arms. Conclusions: For patients undergoing dialysis, both BMI and HEP may be helpful interventions for depression symptoms, and BMI may be superior to HEP for anxiety symptoms. Mindfulness-based and other psychosocial interventions may be further evaluated in those undergoing dialysis as treatment options for symptoms of depression and anxiety. |
format | Online Article Text |
id | pubmed-8228217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82282172021-06-26 Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial Nassim, Marouane Park, Haley Dikaios, Elena Potes, Angela Elbaz, Sasha Mc Veigh, Clare Lipman, Mark Novak, Marta Trinh, Emilie Alam, Ahsan Suri, Rita S. Thomas, Zoe Torres-Platas, Susana Vasudev, Akshya Sasi, Neeti Gautier, Maryse Mucsi, Istvan Noble, Helen Rej, Soham Healthcare (Basel) Article Background: Between 20–50% of patients undergoing maintenance dialysis for end-stage kidney disease experience symptoms of depression and/or anxiety, associated with increased mortality, greater health care utilization, and decreased quality of life. It is unknown whether mindfulness-based interventions can improve depression and anxiety symptoms in patients receiving this treatment. Methods: We conducted an 8-week multicenter randomized controlled trial comparing a brief mindfulness intervention (BMI) vs. an active control (Health Enhancement Program [HEP]) in 55 patients receiving dialysis with symptoms of depression and/or anxiety. The primary outcome was change in Patient Health Questionnaire-9 (PHQ-9) depression scores, with a primary analysis in participants with baseline PHQ-9 ≥ 10, and a secondary analysis including all participants. The secondary outcome was change in Generalized Anxiety Disorder-7 (GAD-7) anxiety scores with corresponding primary and secondary analyses. Results: Both BMI and HEP reduced depressive symptoms, with no difference between trial arms (PHQ-9 change = −7.0 vs. −6.1, p = 0.62). BMI was more effective than HEP in reducing anxiety (GAD-7 change = −8.7 vs. −1.4, p = 0.01). Secondary analyses revealed no differences between arms. Conclusions: For patients undergoing dialysis, both BMI and HEP may be helpful interventions for depression symptoms, and BMI may be superior to HEP for anxiety symptoms. Mindfulness-based and other psychosocial interventions may be further evaluated in those undergoing dialysis as treatment options for symptoms of depression and anxiety. MDPI 2021-06-01 /pmc/articles/PMC8228217/ /pubmed/34205915 http://dx.doi.org/10.3390/healthcare9060659 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nassim, Marouane Park, Haley Dikaios, Elena Potes, Angela Elbaz, Sasha Mc Veigh, Clare Lipman, Mark Novak, Marta Trinh, Emilie Alam, Ahsan Suri, Rita S. Thomas, Zoe Torres-Platas, Susana Vasudev, Akshya Sasi, Neeti Gautier, Maryse Mucsi, Istvan Noble, Helen Rej, Soham Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial |
title | Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial |
title_full | Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial |
title_fullStr | Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial |
title_full_unstemmed | Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial |
title_short | Brief Mindfulness Intervention vs. Health Enhancement Program for Patients Undergoing Dialysis: A Randomized Controlled Trial |
title_sort | brief mindfulness intervention vs. health enhancement program for patients undergoing dialysis: a randomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228217/ https://www.ncbi.nlm.nih.gov/pubmed/34205915 http://dx.doi.org/10.3390/healthcare9060659 |
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