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Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications

Recent studies concerning graphene quantum dots (GQDs) focus extensively on their application in biomedicine, exploiting their modifiable optical properties and ability to complex with various molecules via π–π or covalent interactions. Among these nascent findings, the potential therapeutic efficac...

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Autores principales: Kim, Dong Jin, Yoo, Je Min, Suh, Yeonjoon, Kim, Donghoon, Kang, Insung, Moon, Joonhee, Park, Mina, Kim, Juhee, Kang, Kyung-Sun, Hong, Byung Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228242/
https://www.ncbi.nlm.nih.gov/pubmed/34071339
http://dx.doi.org/10.3390/nano11061423
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author Kim, Dong Jin
Yoo, Je Min
Suh, Yeonjoon
Kim, Donghoon
Kang, Insung
Moon, Joonhee
Park, Mina
Kim, Juhee
Kang, Kyung-Sun
Hong, Byung Hee
author_facet Kim, Dong Jin
Yoo, Je Min
Suh, Yeonjoon
Kim, Donghoon
Kang, Insung
Moon, Joonhee
Park, Mina
Kim, Juhee
Kang, Kyung-Sun
Hong, Byung Hee
author_sort Kim, Dong Jin
collection PubMed
description Recent studies concerning graphene quantum dots (GQDs) focus extensively on their application in biomedicine, exploiting their modifiable optical properties and ability to complex with various molecules via π–π or covalent interactions. Among these nascent findings, the potential therapeutic efficacy of GQDs was reported against Parkinson’s disease, which has to date remained incurable. Herein, we present an environmentally friendly approach for synthesizing GQDs through a waste-to-treasure method, specifically from coffee waste to nanodrug. Consistent with the previous findings with carbon fiber-derived GQDs, the inhibitory effects of coffee bean-derived GQDs demonstrated similar effectiveness against abnormal α-synuclein fibrillation and the protection of neurons from relevant subcellular damages. The fact that a GQDs-based nanodrug can be prepared from a non-reusable yet edible source illustrates a potential approach to convert such waste materials into novel therapeutic agents with minimal psychological rejection by patients.
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spelling pubmed-82282422021-06-26 Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications Kim, Dong Jin Yoo, Je Min Suh, Yeonjoon Kim, Donghoon Kang, Insung Moon, Joonhee Park, Mina Kim, Juhee Kang, Kyung-Sun Hong, Byung Hee Nanomaterials (Basel) Communication Recent studies concerning graphene quantum dots (GQDs) focus extensively on their application in biomedicine, exploiting their modifiable optical properties and ability to complex with various molecules via π–π or covalent interactions. Among these nascent findings, the potential therapeutic efficacy of GQDs was reported against Parkinson’s disease, which has to date remained incurable. Herein, we present an environmentally friendly approach for synthesizing GQDs through a waste-to-treasure method, specifically from coffee waste to nanodrug. Consistent with the previous findings with carbon fiber-derived GQDs, the inhibitory effects of coffee bean-derived GQDs demonstrated similar effectiveness against abnormal α-synuclein fibrillation and the protection of neurons from relevant subcellular damages. The fact that a GQDs-based nanodrug can be prepared from a non-reusable yet edible source illustrates a potential approach to convert such waste materials into novel therapeutic agents with minimal psychological rejection by patients. MDPI 2021-05-28 /pmc/articles/PMC8228242/ /pubmed/34071339 http://dx.doi.org/10.3390/nano11061423 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kim, Dong Jin
Yoo, Je Min
Suh, Yeonjoon
Kim, Donghoon
Kang, Insung
Moon, Joonhee
Park, Mina
Kim, Juhee
Kang, Kyung-Sun
Hong, Byung Hee
Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications
title Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications
title_full Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications
title_fullStr Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications
title_full_unstemmed Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications
title_short Graphene Quantum Dots from Carbonized Coffee Bean Wastes for Biomedical Applications
title_sort graphene quantum dots from carbonized coffee bean wastes for biomedical applications
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228242/
https://www.ncbi.nlm.nih.gov/pubmed/34071339
http://dx.doi.org/10.3390/nano11061423
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