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Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

The development of clinically relevant anti-microRNA antisense oligonucleotides (anti-miRNA ASOs) remains a major challenge. One promising configuration of anti-miRNA ASOs called “tiny LNA (tiny Locked Nucleic Acid)” is an unusually small (~8-mer), highly chemically modified anti-miRNA ASO with high...

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Detalles Bibliográficos
Autores principales:	Yamamoto, Tsuyoshi, Mukai, Yahiro, Wada, Fumito, Terada, Chisato, Kayaba, Yukina, Oh, Kaho, Yamayoshi, Asako, Obika, Satoshi, Harada–Shiba, Mariko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228246/ https://www.ncbi.nlm.nih.gov/pubmed/34072682 http://dx.doi.org/10.3390/pharmaceutics13060817

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