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Improved Models of Coalescence Ages of Y-DNA Haplogroups
Databases of commercial DNA-testing companies now contain more customers with sequenced DNA than any completed academic study, leading to growing interest from academic and forensic entities. An important result for both these entities and the test takers themselves is how closely two individuals ar...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228294/ https://www.ncbi.nlm.nih.gov/pubmed/34200049 http://dx.doi.org/10.3390/genes12060862 |
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author | McDonald, Iain |
author_facet | McDonald, Iain |
author_sort | McDonald, Iain |
collection | PubMed |
description | Databases of commercial DNA-testing companies now contain more customers with sequenced DNA than any completed academic study, leading to growing interest from academic and forensic entities. An important result for both these entities and the test takers themselves is how closely two individuals are related in time, as calculated through one or more molecular clocks. For Y-DNA, existing interpretations of these clocks are insufficiently accurate to usefully measure relatedness in historic times. In this article, I update the methods used to calculate coalescence ages (times to most-recent common ancestor, or TMRCAs) using a new, probabilistic statistical model that includes Y-SNP, Y-STR and ancilliary historical data, and provide examples of its use. |
format | Online Article Text |
id | pubmed-8228294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82282942021-06-26 Improved Models of Coalescence Ages of Y-DNA Haplogroups McDonald, Iain Genes (Basel) Article Databases of commercial DNA-testing companies now contain more customers with sequenced DNA than any completed academic study, leading to growing interest from academic and forensic entities. An important result for both these entities and the test takers themselves is how closely two individuals are related in time, as calculated through one or more molecular clocks. For Y-DNA, existing interpretations of these clocks are insufficiently accurate to usefully measure relatedness in historic times. In this article, I update the methods used to calculate coalescence ages (times to most-recent common ancestor, or TMRCAs) using a new, probabilistic statistical model that includes Y-SNP, Y-STR and ancilliary historical data, and provide examples of its use. MDPI 2021-06-04 /pmc/articles/PMC8228294/ /pubmed/34200049 http://dx.doi.org/10.3390/genes12060862 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article McDonald, Iain Improved Models of Coalescence Ages of Y-DNA Haplogroups |
title | Improved Models of Coalescence Ages of Y-DNA Haplogroups |
title_full | Improved Models of Coalescence Ages of Y-DNA Haplogroups |
title_fullStr | Improved Models of Coalescence Ages of Y-DNA Haplogroups |
title_full_unstemmed | Improved Models of Coalescence Ages of Y-DNA Haplogroups |
title_short | Improved Models of Coalescence Ages of Y-DNA Haplogroups |
title_sort | improved models of coalescence ages of y-dna haplogroups |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228294/ https://www.ncbi.nlm.nih.gov/pubmed/34200049 http://dx.doi.org/10.3390/genes12060862 |
work_keys_str_mv | AT mcdonaldiain improvedmodelsofcoalescenceagesofydnahaplogroups |