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The Multiple Functions of Rho GTPases in Fission Yeasts

The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the past few decades. In recent years, another fissio...

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Autores principales: Vicente-Soler, Jero, Soto, Teresa, Franco, Alejandro, Cansado, José, Madrid, Marisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228308/
https://www.ncbi.nlm.nih.gov/pubmed/34200466
http://dx.doi.org/10.3390/cells10061422
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author Vicente-Soler, Jero
Soto, Teresa
Franco, Alejandro
Cansado, José
Madrid, Marisa
author_facet Vicente-Soler, Jero
Soto, Teresa
Franco, Alejandro
Cansado, José
Madrid, Marisa
author_sort Vicente-Soler, Jero
collection PubMed
description The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the past few decades. In recent years, another fission yeast species, Schizosaccharomyces japonicus, has come into focus offering insight into evolutionary changes within the genus. Both fission yeasts contain only six Rho-type GTPases that are spatiotemporally controlled by multiple guanine–nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and whose intricate regulation in response to external cues is starting to be uncovered. In the present review, we will outline and discuss the current knowledge and recent advances on how the fission yeasts Rho family GTPases regulate essential physiological processes such as morphogenesis and polarity, cellular integrity, cytokinesis and cellular differentiation.
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spelling pubmed-82283082021-06-26 The Multiple Functions of Rho GTPases in Fission Yeasts Vicente-Soler, Jero Soto, Teresa Franco, Alejandro Cansado, José Madrid, Marisa Cells Review The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the past few decades. In recent years, another fission yeast species, Schizosaccharomyces japonicus, has come into focus offering insight into evolutionary changes within the genus. Both fission yeasts contain only six Rho-type GTPases that are spatiotemporally controlled by multiple guanine–nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and whose intricate regulation in response to external cues is starting to be uncovered. In the present review, we will outline and discuss the current knowledge and recent advances on how the fission yeasts Rho family GTPases regulate essential physiological processes such as morphogenesis and polarity, cellular integrity, cytokinesis and cellular differentiation. MDPI 2021-06-07 /pmc/articles/PMC8228308/ /pubmed/34200466 http://dx.doi.org/10.3390/cells10061422 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vicente-Soler, Jero
Soto, Teresa
Franco, Alejandro
Cansado, José
Madrid, Marisa
The Multiple Functions of Rho GTPases in Fission Yeasts
title The Multiple Functions of Rho GTPases in Fission Yeasts
title_full The Multiple Functions of Rho GTPases in Fission Yeasts
title_fullStr The Multiple Functions of Rho GTPases in Fission Yeasts
title_full_unstemmed The Multiple Functions of Rho GTPases in Fission Yeasts
title_short The Multiple Functions of Rho GTPases in Fission Yeasts
title_sort multiple functions of rho gtpases in fission yeasts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228308/
https://www.ncbi.nlm.nih.gov/pubmed/34200466
http://dx.doi.org/10.3390/cells10061422
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