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Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury

Traumatic brain injury (TBI) is a major health and socioeconomic problem affecting the world. This condition results from the application of external physical force to the brain which leads to transient or permanent structural and functional impairments. TBI has been shown to be a risk factor for ne...

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Autores principales: D’Amico, Ramona, Trovato Salinaro, Angela, Fusco, Roberta, Cordaro, Marika, Impellizzeri, Daniela, Scuto, Maria, Ontario, Maria Laura, Lo Dico, Gianluigi, Cuzzocrea, Salvatore, Di Paola, Rosanna, Siracusa, Rosalba, Calabrese, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228340/
https://www.ncbi.nlm.nih.gov/pubmed/34199629
http://dx.doi.org/10.3390/antiox10060898
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author D’Amico, Ramona
Trovato Salinaro, Angela
Fusco, Roberta
Cordaro, Marika
Impellizzeri, Daniela
Scuto, Maria
Ontario, Maria Laura
Lo Dico, Gianluigi
Cuzzocrea, Salvatore
Di Paola, Rosanna
Siracusa, Rosalba
Calabrese, Vittorio
author_facet D’Amico, Ramona
Trovato Salinaro, Angela
Fusco, Roberta
Cordaro, Marika
Impellizzeri, Daniela
Scuto, Maria
Ontario, Maria Laura
Lo Dico, Gianluigi
Cuzzocrea, Salvatore
Di Paola, Rosanna
Siracusa, Rosalba
Calabrese, Vittorio
author_sort D’Amico, Ramona
collection PubMed
description Traumatic brain injury (TBI) is a major health and socioeconomic problem affecting the world. This condition results from the application of external physical force to the brain which leads to transient or permanent structural and functional impairments. TBI has been shown to be a risk factor for neurodegeneration which can lead to Parkinson’s disease (PD) for example. In this study, we wanted to explore the development of PD-related pathology in the context of an experimental model of TBI and the potential ability of Coriolus versicolor and Hericium erinaceus to prevent neurodegenerative processes. Traumatic brain injury was induced in mice by controlled cortical impact. Behavioral tests were performed at various times: the animals were sacrificed 30 days after the impact and the brain was processed for Western blot and immunohistochemical analyzes. After the head injury, a significant decrease in the expression of tyrosine hydroxylase and the dopamine transporter in the substantia nigra was observed, as well as significant behavioral alterations that were instead restored following daily oral treatment with Hericium erinaceus and Coriolus versicolor. Furthermore, a strong increase in neuroinflammation and oxidative stress emerged in the vehicle groups. Treatment with Hericium erinaceus and Coriolus versicolor was able to prevent both the neuroinflammatory and oxidative processes typical of PD. This study suggests that PD-related molecular events may be triggered on TBI and that nutritional fungi such as Hericium erinaceus and Coriolus versicolor may be important in redox stress response mechanisms and neuroprotection, preventing the progression of neurodegenerative diseases such as PD.
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spelling pubmed-82283402021-06-26 Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury D’Amico, Ramona Trovato Salinaro, Angela Fusco, Roberta Cordaro, Marika Impellizzeri, Daniela Scuto, Maria Ontario, Maria Laura Lo Dico, Gianluigi Cuzzocrea, Salvatore Di Paola, Rosanna Siracusa, Rosalba Calabrese, Vittorio Antioxidants (Basel) Article Traumatic brain injury (TBI) is a major health and socioeconomic problem affecting the world. This condition results from the application of external physical force to the brain which leads to transient or permanent structural and functional impairments. TBI has been shown to be a risk factor for neurodegeneration which can lead to Parkinson’s disease (PD) for example. In this study, we wanted to explore the development of PD-related pathology in the context of an experimental model of TBI and the potential ability of Coriolus versicolor and Hericium erinaceus to prevent neurodegenerative processes. Traumatic brain injury was induced in mice by controlled cortical impact. Behavioral tests were performed at various times: the animals were sacrificed 30 days after the impact and the brain was processed for Western blot and immunohistochemical analyzes. After the head injury, a significant decrease in the expression of tyrosine hydroxylase and the dopamine transporter in the substantia nigra was observed, as well as significant behavioral alterations that were instead restored following daily oral treatment with Hericium erinaceus and Coriolus versicolor. Furthermore, a strong increase in neuroinflammation and oxidative stress emerged in the vehicle groups. Treatment with Hericium erinaceus and Coriolus versicolor was able to prevent both the neuroinflammatory and oxidative processes typical of PD. This study suggests that PD-related molecular events may be triggered on TBI and that nutritional fungi such as Hericium erinaceus and Coriolus versicolor may be important in redox stress response mechanisms and neuroprotection, preventing the progression of neurodegenerative diseases such as PD. MDPI 2021-06-02 /pmc/articles/PMC8228340/ /pubmed/34199629 http://dx.doi.org/10.3390/antiox10060898 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Amico, Ramona
Trovato Salinaro, Angela
Fusco, Roberta
Cordaro, Marika
Impellizzeri, Daniela
Scuto, Maria
Ontario, Maria Laura
Lo Dico, Gianluigi
Cuzzocrea, Salvatore
Di Paola, Rosanna
Siracusa, Rosalba
Calabrese, Vittorio
Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
title Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
title_full Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
title_fullStr Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
title_full_unstemmed Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
title_short Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
title_sort hericium erinaceus and coriolus versicolor modulate molecular and biochemical changes after traumatic brain injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228340/
https://www.ncbi.nlm.nih.gov/pubmed/34199629
http://dx.doi.org/10.3390/antiox10060898
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