SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2

During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (...

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Detalles Bibliográficos
Autores principales: Zavyalova, Elena, Ambartsumyan, Oganes, Zhdanov, Gleb, Gribanyov, Dmitry, Gushchin, Vladimir, Tkachuk, Artem, Rudakova, Elena, Nikiforova, Maria, Kuznetsova, Nadezhda, Popova, Liubov, Verdiev, Bakhtiyar, Alatyrev, Artem, Burtseva, Elena, Ignatieva, Anna, Iliukhina, Anna, Dolzhikova, Inna, Arutyunyan, Alexander, Gambaryan, Alexandra, Kukushkin, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228355/
https://www.ncbi.nlm.nih.gov/pubmed/34070421
http://dx.doi.org/10.3390/nano11061394
Descripción
Sumario:During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expensive construction and implementation. In this paper, we provide a SERS-aptasensor based on colloidal solutions which combines rapidity and specificity in quantitative determination of SARS-CoV-2 virus, discriminating it from the other respiratory viruses.

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