Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside

This review summarizes the main achievements in basic and clinical research of atherosclerosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the atherogenic properties of low density lipoprotein...

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Autores principales: Mezentsev, Alexandre, Bezsonov, Evgeny, Kashirskikh, Dmitry, Baig, Mirza S., Eid, Ali H., Orekhov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228531/
https://www.ncbi.nlm.nih.gov/pubmed/34070542
http://dx.doi.org/10.3390/biomedicines9060600
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author Mezentsev, Alexandre
Bezsonov, Evgeny
Kashirskikh, Dmitry
Baig, Mirza S.
Eid, Ali H.
Orekhov, Alexander
author_facet Mezentsev, Alexandre
Bezsonov, Evgeny
Kashirskikh, Dmitry
Baig, Mirza S.
Eid, Ali H.
Orekhov, Alexander
author_sort Mezentsev, Alexandre
collection PubMed
description This review summarizes the main achievements in basic and clinical research of atherosclerosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the atherogenic properties of low density lipoproteins and decreases the anti-atherogenic properties of high density lipoproteins. The separate sections of this paper are devoted to immunogenicity of lipoproteins, the enzymes contributing to their desialylation and animal models of atherosclerosis. In addition, we evaluate the available experimental and diagnostic protocols that can be used to develop new therapeutic approaches for atherosclerosis.
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spelling pubmed-82285312021-06-26 Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside Mezentsev, Alexandre Bezsonov, Evgeny Kashirskikh, Dmitry Baig, Mirza S. Eid, Ali H. Orekhov, Alexander Biomedicines Review This review summarizes the main achievements in basic and clinical research of atherosclerosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the atherogenic properties of low density lipoproteins and decreases the anti-atherogenic properties of high density lipoproteins. The separate sections of this paper are devoted to immunogenicity of lipoproteins, the enzymes contributing to their desialylation and animal models of atherosclerosis. In addition, we evaluate the available experimental and diagnostic protocols that can be used to develop new therapeutic approaches for atherosclerosis. MDPI 2021-05-25 /pmc/articles/PMC8228531/ /pubmed/34070542 http://dx.doi.org/10.3390/biomedicines9060600 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mezentsev, Alexandre
Bezsonov, Evgeny
Kashirskikh, Dmitry
Baig, Mirza S.
Eid, Ali H.
Orekhov, Alexander
Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside
title Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside
title_full Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside
title_fullStr Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside
title_full_unstemmed Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside
title_short Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside
title_sort proatherogenic sialidases and desialylated lipoproteins: 35 years of research and current state from bench to bedside
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228531/
https://www.ncbi.nlm.nih.gov/pubmed/34070542
http://dx.doi.org/10.3390/biomedicines9060600
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