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Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance

Non-polio enteroviruses (NPEV) and parechoviruses (PeV) are widespread pathogens that cause significant morbidity. Surveillance is based on culturing or genotyping of virus strains found in clinical samples. Sero-surveillance, by measuring neutralising antibodies (nAb) through virus neutralisation a...

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Autores principales: Couderé, Karen, van der Straten, Karlijn, Brouwer, Lieke, Koen, Gerrit, van Eijk, Hetty, Pajkrt, Dasja, Murk, Jean-Luc, Wolthers, Katja C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228535/
https://www.ncbi.nlm.nih.gov/pubmed/34072486
http://dx.doi.org/10.3390/v13061028
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author Couderé, Karen
van der Straten, Karlijn
Brouwer, Lieke
Koen, Gerrit
van Eijk, Hetty
Pajkrt, Dasja
Murk, Jean-Luc
Wolthers, Katja C.
author_facet Couderé, Karen
van der Straten, Karlijn
Brouwer, Lieke
Koen, Gerrit
van Eijk, Hetty
Pajkrt, Dasja
Murk, Jean-Luc
Wolthers, Katja C.
author_sort Couderé, Karen
collection PubMed
description Non-polio enteroviruses (NPEV) and parechoviruses (PeV) are widespread pathogens that cause significant morbidity. Surveillance is based on culturing or genotyping of virus strains found in clinical samples. Sero-surveillance, by measuring neutralising antibodies (nAb) through virus neutralisation assays (VNA), could provide additional information as it offers a more comprehensive overview of exposure to circulating types in the general population. In our study we evaluated Intravenous immunoglobulins (IVIG) to generate sero-surveillance data. We performed VNA of nineteen NPEV and PeV with Dutch IVIG batches from two different time points (2010 and 2017) and an IVIG batch from Vietnam (2011). We compared our findings with geno- and sero-surveillance data and evaluated changes over time and between the two countries. Our findings show a good correlation with what is known from geno-surveillance data. The highest nAb titres were found against strains from Enterovirus B, while we did not observe nAb titres against strains belonging to Enterovirus C. In conclusion, we demonstrated that sero-surveillance by means of IVIG can be used to obtain insight into circulation of EV and PeV genotypes. This is of particular interest for public health, to evaluate changes over time and population susceptibility to emerging genotypes.
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spelling pubmed-82285352021-06-26 Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance Couderé, Karen van der Straten, Karlijn Brouwer, Lieke Koen, Gerrit van Eijk, Hetty Pajkrt, Dasja Murk, Jean-Luc Wolthers, Katja C. Viruses Article Non-polio enteroviruses (NPEV) and parechoviruses (PeV) are widespread pathogens that cause significant morbidity. Surveillance is based on culturing or genotyping of virus strains found in clinical samples. Sero-surveillance, by measuring neutralising antibodies (nAb) through virus neutralisation assays (VNA), could provide additional information as it offers a more comprehensive overview of exposure to circulating types in the general population. In our study we evaluated Intravenous immunoglobulins (IVIG) to generate sero-surveillance data. We performed VNA of nineteen NPEV and PeV with Dutch IVIG batches from two different time points (2010 and 2017) and an IVIG batch from Vietnam (2011). We compared our findings with geno- and sero-surveillance data and evaluated changes over time and between the two countries. Our findings show a good correlation with what is known from geno-surveillance data. The highest nAb titres were found against strains from Enterovirus B, while we did not observe nAb titres against strains belonging to Enterovirus C. In conclusion, we demonstrated that sero-surveillance by means of IVIG can be used to obtain insight into circulation of EV and PeV genotypes. This is of particular interest for public health, to evaluate changes over time and population susceptibility to emerging genotypes. MDPI 2021-05-29 /pmc/articles/PMC8228535/ /pubmed/34072486 http://dx.doi.org/10.3390/v13061028 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Couderé, Karen
van der Straten, Karlijn
Brouwer, Lieke
Koen, Gerrit
van Eijk, Hetty
Pajkrt, Dasja
Murk, Jean-Luc
Wolthers, Katja C.
Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance
title Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance
title_full Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance
title_fullStr Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance
title_full_unstemmed Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance
title_short Neutralising Antibodies against Enterovirus and Parechovirus in IVIG Reflect General Circulation: A Tool for Sero-Surveillance
title_sort neutralising antibodies against enterovirus and parechovirus in ivig reflect general circulation: a tool for sero-surveillance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228535/
https://www.ncbi.nlm.nih.gov/pubmed/34072486
http://dx.doi.org/10.3390/v13061028
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