Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines

SIMPLE SUMMARY: Glioblastoma multiforme (GBM) is the most common as well as the most aggressive malignant brain tumor, with an overall survival of almost 15 months. Histone deacetylase 6 (HDAC6), an enzyme related to the deacetylation of α-tubulin, is overexpressed in GBM. The aim of our research wa...

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Detalles Bibliográficos
Autores principales: Urdiciain, Alejandro, Erausquin, Elena, Zelaya, María V., Zazpe, Idoya, Lanciego, José L., Meléndez, Bárbara, Rey, Juan A., Idoate, Miguel A., Riobo-Del Galdo, Natalia A., Castresana, Javier S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228543/
https://www.ncbi.nlm.nih.gov/pubmed/34073238
http://dx.doi.org/10.3390/biology10060467

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