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Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228554/ https://www.ncbi.nlm.nih.gov/pubmed/34201298 http://dx.doi.org/10.3390/molecules26123494 |
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author | Dias, Ana S. Helguero, Luisa Almeida, Catarina R. Duarte, Iola F. |
author_facet | Dias, Ana S. Helguero, Luisa Almeida, Catarina R. Duarte, Iola F. |
author_sort | Dias, Ana S. |
collection | PubMed |
description | The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to ‘(re)-educate’ TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression. |
format | Online Article Text |
id | pubmed-8228554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82285542021-06-26 Natural Compounds as Metabolic Modulators of the Tumor Microenvironment Dias, Ana S. Helguero, Luisa Almeida, Catarina R. Duarte, Iola F. Molecules Review The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to ‘(re)-educate’ TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression. MDPI 2021-06-08 /pmc/articles/PMC8228554/ /pubmed/34201298 http://dx.doi.org/10.3390/molecules26123494 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dias, Ana S. Helguero, Luisa Almeida, Catarina R. Duarte, Iola F. Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
title | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
title_full | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
title_fullStr | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
title_full_unstemmed | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
title_short | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
title_sort | natural compounds as metabolic modulators of the tumor microenvironment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228554/ https://www.ncbi.nlm.nih.gov/pubmed/34201298 http://dx.doi.org/10.3390/molecules26123494 |
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