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Natural Compounds as Metabolic Modulators of the Tumor Microenvironment

The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation...

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Detalles Bibliográficos
Autores principales: Dias, Ana S., Helguero, Luisa, Almeida, Catarina R., Duarte, Iola F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228554/
https://www.ncbi.nlm.nih.gov/pubmed/34201298
http://dx.doi.org/10.3390/molecules26123494
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author Dias, Ana S.
Helguero, Luisa
Almeida, Catarina R.
Duarte, Iola F.
author_facet Dias, Ana S.
Helguero, Luisa
Almeida, Catarina R.
Duarte, Iola F.
author_sort Dias, Ana S.
collection PubMed
description The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to ‘(re)-educate’ TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression.
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spelling pubmed-82285542021-06-26 Natural Compounds as Metabolic Modulators of the Tumor Microenvironment Dias, Ana S. Helguero, Luisa Almeida, Catarina R. Duarte, Iola F. Molecules Review The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to ‘(re)-educate’ TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression. MDPI 2021-06-08 /pmc/articles/PMC8228554/ /pubmed/34201298 http://dx.doi.org/10.3390/molecules26123494 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dias, Ana S.
Helguero, Luisa
Almeida, Catarina R.
Duarte, Iola F.
Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
title Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
title_full Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
title_fullStr Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
title_full_unstemmed Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
title_short Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
title_sort natural compounds as metabolic modulators of the tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228554/
https://www.ncbi.nlm.nih.gov/pubmed/34201298
http://dx.doi.org/10.3390/molecules26123494
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