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Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver

The fungus strain DZ-3 was isolated from twigs of the well-known medicinal plant Eucommia ulmoides Oliver and identified as Aspergillus flavipes. Two new alkaloids, named asperflaloids A and B (1 and 2), together with 10 known compounds (3–12) were obtained from the EtOAc extract of the strain. Inte...

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Autores principales: Liu, Wan, Liu, Yu, Yang, Fan, Han, Shouye, Zhang, Jia, Yang, Hui, Cheng, Zhongbin, Li, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228597/
https://www.ncbi.nlm.nih.gov/pubmed/34207657
http://dx.doi.org/10.3390/molecules26123514
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author Liu, Wan
Liu, Yu
Yang, Fan
Han, Shouye
Zhang, Jia
Yang, Hui
Cheng, Zhongbin
Li, Qin
author_facet Liu, Wan
Liu, Yu
Yang, Fan
Han, Shouye
Zhang, Jia
Yang, Hui
Cheng, Zhongbin
Li, Qin
author_sort Liu, Wan
collection PubMed
description The fungus strain DZ-3 was isolated from twigs of the well-known medicinal plant Eucommia ulmoides Oliver and identified as Aspergillus flavipes. Two new alkaloids, named asperflaloids A and B (1 and 2), together with 10 known compounds (3–12) were obtained from the EtOAc extract of the strain. Interestingly, the alkaloids 1–4 with different frameworks are characterized by the presence of the same anthranilic acid residue. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of asperflaloids A and B was resolved by quantum chemistry calculation. All compounds were screened for their inhibitions against α-glucosidase and the antioxidant capacities. The results were that compound 3 had an IC(50) value of 750.8 μM toward α-glucosidase, and the phenol compounds 7 and 8 exhibited potent antioxidant capacities with IC(50) values 14.4 and 27.1 μM respectively.
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spelling pubmed-82285972021-06-26 Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver Liu, Wan Liu, Yu Yang, Fan Han, Shouye Zhang, Jia Yang, Hui Cheng, Zhongbin Li, Qin Molecules Article The fungus strain DZ-3 was isolated from twigs of the well-known medicinal plant Eucommia ulmoides Oliver and identified as Aspergillus flavipes. Two new alkaloids, named asperflaloids A and B (1 and 2), together with 10 known compounds (3–12) were obtained from the EtOAc extract of the strain. Interestingly, the alkaloids 1–4 with different frameworks are characterized by the presence of the same anthranilic acid residue. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of asperflaloids A and B was resolved by quantum chemistry calculation. All compounds were screened for their inhibitions against α-glucosidase and the antioxidant capacities. The results were that compound 3 had an IC(50) value of 750.8 μM toward α-glucosidase, and the phenol compounds 7 and 8 exhibited potent antioxidant capacities with IC(50) values 14.4 and 27.1 μM respectively. MDPI 2021-06-09 /pmc/articles/PMC8228597/ /pubmed/34207657 http://dx.doi.org/10.3390/molecules26123514 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Wan
Liu, Yu
Yang, Fan
Han, Shouye
Zhang, Jia
Yang, Hui
Cheng, Zhongbin
Li, Qin
Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver
title Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver
title_full Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver
title_fullStr Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver
title_full_unstemmed Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver
title_short Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver
title_sort asperflaloids a and b from aspergillus flavipes dz-3, an endophytic fungus of eucommia ulmoides oliver
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228597/
https://www.ncbi.nlm.nih.gov/pubmed/34207657
http://dx.doi.org/10.3390/molecules26123514
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