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Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi
Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to rep...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228598/ https://www.ncbi.nlm.nih.gov/pubmed/34198839 http://dx.doi.org/10.3390/genes12060867 |
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author | Edgar, Allison Mitchell, Dorothy G. Martindale, Mark Q. |
author_facet | Edgar, Allison Mitchell, Dorothy G. Martindale, Mark Q. |
author_sort | Edgar, Allison |
collection | PubMed |
description | Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, Mnemiopsis leidyi, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. M. leidyi’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration. |
format | Online Article Text |
id | pubmed-8228598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82285982021-06-26 Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi Edgar, Allison Mitchell, Dorothy G. Martindale, Mark Q. Genes (Basel) Review Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, Mnemiopsis leidyi, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. M. leidyi’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration. MDPI 2021-06-05 /pmc/articles/PMC8228598/ /pubmed/34198839 http://dx.doi.org/10.3390/genes12060867 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Edgar, Allison Mitchell, Dorothy G. Martindale, Mark Q. Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi |
title | Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi |
title_full | Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi |
title_fullStr | Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi |
title_full_unstemmed | Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi |
title_short | Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi |
title_sort | whole-body regeneration in the lobate ctenophore mnemiopsis leidyi |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228598/ https://www.ncbi.nlm.nih.gov/pubmed/34198839 http://dx.doi.org/10.3390/genes12060867 |
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