Cargando…

Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi

Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to rep...

Descripción completa

Detalles Bibliográficos
Autores principales: Edgar, Allison, Mitchell, Dorothy G., Martindale, Mark Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228598/
https://www.ncbi.nlm.nih.gov/pubmed/34198839
http://dx.doi.org/10.3390/genes12060867
_version_ 1783712779742478336
author Edgar, Allison
Mitchell, Dorothy G.
Martindale, Mark Q.
author_facet Edgar, Allison
Mitchell, Dorothy G.
Martindale, Mark Q.
author_sort Edgar, Allison
collection PubMed
description Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, Mnemiopsis leidyi, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. M. leidyi’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration.
format Online
Article
Text
id pubmed-8228598
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82285982021-06-26 Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi Edgar, Allison Mitchell, Dorothy G. Martindale, Mark Q. Genes (Basel) Review Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, Mnemiopsis leidyi, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. M. leidyi’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration. MDPI 2021-06-05 /pmc/articles/PMC8228598/ /pubmed/34198839 http://dx.doi.org/10.3390/genes12060867 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Edgar, Allison
Mitchell, Dorothy G.
Martindale, Mark Q.
Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi
title Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi
title_full Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi
title_fullStr Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi
title_full_unstemmed Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi
title_short Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi
title_sort whole-body regeneration in the lobate ctenophore mnemiopsis leidyi
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228598/
https://www.ncbi.nlm.nih.gov/pubmed/34198839
http://dx.doi.org/10.3390/genes12060867
work_keys_str_mv AT edgarallison wholebodyregenerationinthelobatectenophoremnemiopsisleidyi
AT mitchelldorothyg wholebodyregenerationinthelobatectenophoremnemiopsisleidyi
AT martindalemarkq wholebodyregenerationinthelobatectenophoremnemiopsisleidyi