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Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord
The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identifi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228677/ https://www.ncbi.nlm.nih.gov/pubmed/34204045 http://dx.doi.org/10.3390/cells10061404 |
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author | Tsata, Vasiliki Wehner, Daniel |
author_facet | Tsata, Vasiliki Wehner, Daniel |
author_sort | Tsata, Vasiliki |
collection | PubMed |
description | The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identification of target cells that react to the injury and the cues directing their pro-regenerative responses. Among existing models of successful spinal cord regeneration, the zebrafish is arguably the most understood at a mechanistic level to date. Here, we review the spinal cord injury paradigms used in zebrafish, and summarize the breadth of neuron-intrinsic and -extrinsic factors that have been identified to play pivotal roles in the ability of zebrafish to regenerate central nervous system axons and recover function. |
format | Online Article Text |
id | pubmed-8228677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82286772021-06-26 Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord Tsata, Vasiliki Wehner, Daniel Cells Review The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identification of target cells that react to the injury and the cues directing their pro-regenerative responses. Among existing models of successful spinal cord regeneration, the zebrafish is arguably the most understood at a mechanistic level to date. Here, we review the spinal cord injury paradigms used in zebrafish, and summarize the breadth of neuron-intrinsic and -extrinsic factors that have been identified to play pivotal roles in the ability of zebrafish to regenerate central nervous system axons and recover function. MDPI 2021-06-06 /pmc/articles/PMC8228677/ /pubmed/34204045 http://dx.doi.org/10.3390/cells10061404 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tsata, Vasiliki Wehner, Daniel Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord |
title | Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord |
title_full | Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord |
title_fullStr | Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord |
title_full_unstemmed | Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord |
title_short | Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord |
title_sort | know how to regrow—axon regeneration in the zebrafish spinal cord |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228677/ https://www.ncbi.nlm.nih.gov/pubmed/34204045 http://dx.doi.org/10.3390/cells10061404 |
work_keys_str_mv | AT tsatavasiliki knowhowtoregrowaxonregenerationinthezebrafishspinalcord AT wehnerdaniel knowhowtoregrowaxonregenerationinthezebrafishspinalcord |