Cargando…

Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord

The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsata, Vasiliki, Wehner, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228677/
https://www.ncbi.nlm.nih.gov/pubmed/34204045
http://dx.doi.org/10.3390/cells10061404
_version_ 1783712798207901696
author Tsata, Vasiliki
Wehner, Daniel
author_facet Tsata, Vasiliki
Wehner, Daniel
author_sort Tsata, Vasiliki
collection PubMed
description The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identification of target cells that react to the injury and the cues directing their pro-regenerative responses. Among existing models of successful spinal cord regeneration, the zebrafish is arguably the most understood at a mechanistic level to date. Here, we review the spinal cord injury paradigms used in zebrafish, and summarize the breadth of neuron-intrinsic and -extrinsic factors that have been identified to play pivotal roles in the ability of zebrafish to regenerate central nervous system axons and recover function.
format Online
Article
Text
id pubmed-8228677
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82286772021-06-26 Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord Tsata, Vasiliki Wehner, Daniel Cells Review The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identification of target cells that react to the injury and the cues directing their pro-regenerative responses. Among existing models of successful spinal cord regeneration, the zebrafish is arguably the most understood at a mechanistic level to date. Here, we review the spinal cord injury paradigms used in zebrafish, and summarize the breadth of neuron-intrinsic and -extrinsic factors that have been identified to play pivotal roles in the ability of zebrafish to regenerate central nervous system axons and recover function. MDPI 2021-06-06 /pmc/articles/PMC8228677/ /pubmed/34204045 http://dx.doi.org/10.3390/cells10061404 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tsata, Vasiliki
Wehner, Daniel
Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord
title Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord
title_full Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord
title_fullStr Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord
title_full_unstemmed Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord
title_short Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord
title_sort know how to regrow—axon regeneration in the zebrafish spinal cord
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228677/
https://www.ncbi.nlm.nih.gov/pubmed/34204045
http://dx.doi.org/10.3390/cells10061404
work_keys_str_mv AT tsatavasiliki knowhowtoregrowaxonregenerationinthezebrafishspinalcord
AT wehnerdaniel knowhowtoregrowaxonregenerationinthezebrafishspinalcord