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The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease

Mitochondrial dysfunction has a fundamental role in the development of idiopathic and familiar forms of Parkinson’s disease (PD). The nuclear-encoded mitochondrial kinase PINK1, linked to familial PD, is responsible for diverse mechanisms of mitochondrial quality control, ATP production, mitochondri...

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Autores principales: Leites, Elvira Pequeno, Morais, Vanessa Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228719/
https://www.ncbi.nlm.nih.gov/pubmed/34198743
http://dx.doi.org/10.3390/cells10061395
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author Leites, Elvira Pequeno
Morais, Vanessa Alexandra
author_facet Leites, Elvira Pequeno
Morais, Vanessa Alexandra
author_sort Leites, Elvira Pequeno
collection PubMed
description Mitochondrial dysfunction has a fundamental role in the development of idiopathic and familiar forms of Parkinson’s disease (PD). The nuclear-encoded mitochondrial kinase PINK1, linked to familial PD, is responsible for diverse mechanisms of mitochondrial quality control, ATP production, mitochondrial-mediated apoptosis and neuroinflammation. The main pathological hallmark of PD is the loss of dopaminergic neurons. However, novel discoveries have brought forward the concept that a disruption in overall brain homeostasis may be the underlying cause of this neurodegeneration disease. To sustain this, astrocytes and microglia cells lacking PINK1 have revealed increased neuroinflammation and deficits in physiological roles, such as decreased wound healing capacity and ATP production, which clearly indicate involvement of these cells in the physiopathology of PD. PINK1 executes vital functions within mitochondrial regulation that have a detrimental impact on the development and progression of PD. Hence, in this review, we aim to broaden the horizon of PINK1-mediated phenotypes occurring in neurons, astrocytes and microglia and, ultimately, highlight the importance of the crosstalk between these neural cells that is crucial for brain homeostasis.
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spelling pubmed-82287192021-06-26 The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease Leites, Elvira Pequeno Morais, Vanessa Alexandra Cells Review Mitochondrial dysfunction has a fundamental role in the development of idiopathic and familiar forms of Parkinson’s disease (PD). The nuclear-encoded mitochondrial kinase PINK1, linked to familial PD, is responsible for diverse mechanisms of mitochondrial quality control, ATP production, mitochondrial-mediated apoptosis and neuroinflammation. The main pathological hallmark of PD is the loss of dopaminergic neurons. However, novel discoveries have brought forward the concept that a disruption in overall brain homeostasis may be the underlying cause of this neurodegeneration disease. To sustain this, astrocytes and microglia cells lacking PINK1 have revealed increased neuroinflammation and deficits in physiological roles, such as decreased wound healing capacity and ATP production, which clearly indicate involvement of these cells in the physiopathology of PD. PINK1 executes vital functions within mitochondrial regulation that have a detrimental impact on the development and progression of PD. Hence, in this review, we aim to broaden the horizon of PINK1-mediated phenotypes occurring in neurons, astrocytes and microglia and, ultimately, highlight the importance of the crosstalk between these neural cells that is crucial for brain homeostasis. MDPI 2021-06-05 /pmc/articles/PMC8228719/ /pubmed/34198743 http://dx.doi.org/10.3390/cells10061395 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Leites, Elvira Pequeno
Morais, Vanessa Alexandra
The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease
title The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease
title_full The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease
title_fullStr The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease
title_full_unstemmed The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease
title_short The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease
title_sort pink1-mediated crosstalk between neural cells and the underlying link to parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228719/
https://www.ncbi.nlm.nih.gov/pubmed/34198743
http://dx.doi.org/10.3390/cells10061395
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