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Malaria in the ‘Omics Era’
Genomics has revolutionised the study of the biology of parasitic diseases. The first Eukaryotic parasite to have its genome sequenced was the malaria parasite Plasmodium falciparum. Since then, Plasmodium genomics has continued to lead the way in the study of the genome biology of parasites, both i...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228830/ https://www.ncbi.nlm.nih.gov/pubmed/34070769 http://dx.doi.org/10.3390/genes12060843 |
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author | Pegoraro, Mirko Weedall, Gareth D. |
author_facet | Pegoraro, Mirko Weedall, Gareth D. |
author_sort | Pegoraro, Mirko |
collection | PubMed |
description | Genomics has revolutionised the study of the biology of parasitic diseases. The first Eukaryotic parasite to have its genome sequenced was the malaria parasite Plasmodium falciparum. Since then, Plasmodium genomics has continued to lead the way in the study of the genome biology of parasites, both in breadth—the number of Plasmodium species’ genomes sequenced—and in depth—massive-scale genome re-sequencing of several key species. Here, we review some of the insights into the biology, evolution and population genetics of Plasmodium gained from genome sequencing, and look at potential new avenues in the future genome-scale study of its biology. |
format | Online Article Text |
id | pubmed-8228830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82288302021-06-26 Malaria in the ‘Omics Era’ Pegoraro, Mirko Weedall, Gareth D. Genes (Basel) Review Genomics has revolutionised the study of the biology of parasitic diseases. The first Eukaryotic parasite to have its genome sequenced was the malaria parasite Plasmodium falciparum. Since then, Plasmodium genomics has continued to lead the way in the study of the genome biology of parasites, both in breadth—the number of Plasmodium species’ genomes sequenced—and in depth—massive-scale genome re-sequencing of several key species. Here, we review some of the insights into the biology, evolution and population genetics of Plasmodium gained from genome sequencing, and look at potential new avenues in the future genome-scale study of its biology. MDPI 2021-05-30 /pmc/articles/PMC8228830/ /pubmed/34070769 http://dx.doi.org/10.3390/genes12060843 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pegoraro, Mirko Weedall, Gareth D. Malaria in the ‘Omics Era’ |
title | Malaria in the ‘Omics Era’ |
title_full | Malaria in the ‘Omics Era’ |
title_fullStr | Malaria in the ‘Omics Era’ |
title_full_unstemmed | Malaria in the ‘Omics Era’ |
title_short | Malaria in the ‘Omics Era’ |
title_sort | malaria in the ‘omics era’ |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228830/ https://www.ncbi.nlm.nih.gov/pubmed/34070769 http://dx.doi.org/10.3390/genes12060843 |
work_keys_str_mv | AT pegoraromirko malariaintheomicsera AT weedallgarethd malariaintheomicsera |