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Malaria in the ‘Omics Era’

Genomics has revolutionised the study of the biology of parasitic diseases. The first Eukaryotic parasite to have its genome sequenced was the malaria parasite Plasmodium falciparum. Since then, Plasmodium genomics has continued to lead the way in the study of the genome biology of parasites, both i...

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Detalles Bibliográficos
Autores principales: Pegoraro, Mirko, Weedall, Gareth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228830/
https://www.ncbi.nlm.nih.gov/pubmed/34070769
http://dx.doi.org/10.3390/genes12060843
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author Pegoraro, Mirko
Weedall, Gareth D.
author_facet Pegoraro, Mirko
Weedall, Gareth D.
author_sort Pegoraro, Mirko
collection PubMed
description Genomics has revolutionised the study of the biology of parasitic diseases. The first Eukaryotic parasite to have its genome sequenced was the malaria parasite Plasmodium falciparum. Since then, Plasmodium genomics has continued to lead the way in the study of the genome biology of parasites, both in breadth—the number of Plasmodium species’ genomes sequenced—and in depth—massive-scale genome re-sequencing of several key species. Here, we review some of the insights into the biology, evolution and population genetics of Plasmodium gained from genome sequencing, and look at potential new avenues in the future genome-scale study of its biology.
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spelling pubmed-82288302021-06-26 Malaria in the ‘Omics Era’ Pegoraro, Mirko Weedall, Gareth D. Genes (Basel) Review Genomics has revolutionised the study of the biology of parasitic diseases. The first Eukaryotic parasite to have its genome sequenced was the malaria parasite Plasmodium falciparum. Since then, Plasmodium genomics has continued to lead the way in the study of the genome biology of parasites, both in breadth—the number of Plasmodium species’ genomes sequenced—and in depth—massive-scale genome re-sequencing of several key species. Here, we review some of the insights into the biology, evolution and population genetics of Plasmodium gained from genome sequencing, and look at potential new avenues in the future genome-scale study of its biology. MDPI 2021-05-30 /pmc/articles/PMC8228830/ /pubmed/34070769 http://dx.doi.org/10.3390/genes12060843 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pegoraro, Mirko
Weedall, Gareth D.
Malaria in the ‘Omics Era’
title Malaria in the ‘Omics Era’
title_full Malaria in the ‘Omics Era’
title_fullStr Malaria in the ‘Omics Era’
title_full_unstemmed Malaria in the ‘Omics Era’
title_short Malaria in the ‘Omics Era’
title_sort malaria in the ‘omics era’
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228830/
https://www.ncbi.nlm.nih.gov/pubmed/34070769
http://dx.doi.org/10.3390/genes12060843
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