Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions

Addition of the silylated tag (STag) enables peptides to be highly soluble in CPME, allowing them to be used at high concentrations in a coupling reaction to enhance reactivity and achieve effective synthesis of sterically hindered peptides. We described the development of a continuous one-pot STag-...

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Detalles Bibliográficos
Autores principales: Yano, Shinya, Mori, Toshihiro, Kubota, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228865/
https://www.ncbi.nlm.nih.gov/pubmed/34201337
http://dx.doi.org/10.3390/molecules26123497
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author Yano, Shinya
Mori, Toshihiro
Kubota, Hideki
author_facet Yano, Shinya
Mori, Toshihiro
Kubota, Hideki
author_sort Yano, Shinya
collection PubMed
description Addition of the silylated tag (STag) enables peptides to be highly soluble in CPME, allowing them to be used at high concentrations in a coupling reaction to enhance reactivity and achieve effective synthesis of sterically hindered peptides. We described the development of a continuous one-pot STag-assisted peptide synthesis platform as a method that provides near-stoichiometric, speedy, environmentally friendly, and scalable peptide synthesis.
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spelling pubmed-82288652021-06-26 Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions Yano, Shinya Mori, Toshihiro Kubota, Hideki Molecules Article Addition of the silylated tag (STag) enables peptides to be highly soluble in CPME, allowing them to be used at high concentrations in a coupling reaction to enhance reactivity and achieve effective synthesis of sterically hindered peptides. We described the development of a continuous one-pot STag-assisted peptide synthesis platform as a method that provides near-stoichiometric, speedy, environmentally friendly, and scalable peptide synthesis. MDPI 2021-06-08 /pmc/articles/PMC8228865/ /pubmed/34201337 http://dx.doi.org/10.3390/molecules26123497 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yano, Shinya
Mori, Toshihiro
Kubota, Hideki
Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions
title Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions
title_full Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions
title_fullStr Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions
title_full_unstemmed Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions
title_short Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions
title_sort silylated tag-assisted peptide synthesis: continuous one-pot elongation for the production of difficult peptides under environmentally friendly conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228865/
https://www.ncbi.nlm.nih.gov/pubmed/34201337
http://dx.doi.org/10.3390/molecules26123497
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AT moritoshihiro silylatedtagassistedpeptidesynthesiscontinuousonepotelongationfortheproductionofdifficultpeptidesunderenvironmentallyfriendlyconditions
AT kubotahideki silylatedtagassistedpeptidesynthesiscontinuousonepotelongationfortheproductionofdifficultpeptidesunderenvironmentallyfriendlyconditions

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