Cargando…

The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential

Cydonia oblonga Mill., normally known as the quince fruit, has been widely used in agro-food industries mainly to produce jams and jellies. However, other parts of the plants are still underutilized and not completely assessed for their nutraceutical profile. Therefore, in this work, the polyphenoli...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Leilei, Rocchetti, Gabriele, Zengin, Gökhan, Ak, Gunes, Saber, Fatema R., Montesano, Domenico, Lucini, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228880/
https://www.ncbi.nlm.nih.gov/pubmed/34071443
http://dx.doi.org/10.3390/foods10061230
_version_ 1783712845901332480
author Zhang, Leilei
Rocchetti, Gabriele
Zengin, Gökhan
Ak, Gunes
Saber, Fatema R.
Montesano, Domenico
Lucini, Luigi
author_facet Zhang, Leilei
Rocchetti, Gabriele
Zengin, Gökhan
Ak, Gunes
Saber, Fatema R.
Montesano, Domenico
Lucini, Luigi
author_sort Zhang, Leilei
collection PubMed
description Cydonia oblonga Mill., normally known as the quince fruit, has been widely used in agro-food industries mainly to produce jams and jellies. However, other parts of the plants are still underutilized and not completely assessed for their nutraceutical profile. Therefore, in this work, the polyphenolic profile of C. oblonga was investigated using an untargeted metabolomics approach based on high-resolution mass spectrometry. Several compounds were identified in the different parts of the plants, including flavonoids (i.e., anthocyanins, flavones, flavan-3-ols, and flavonols), phenolic acids (both hydroxycinnamics and hydroxybenzoics), low-molecular-weight phenolics (tyrosol equivalents), lignans, and stilbenes. Overall, C. oblonga leaves showed the highest in vitro antioxidant potential, as revealed by 2,2-difenil-1-picrylhydrazyl (DPPH), 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric ion reducing antioxidant capacity (CUPRAC) assays, being 189.5, 285.6, 158.9, and 348.8 mg Trolox Equivalent/g, respectively. The enzymes acetyl- and butyryl-cholinesterases were both inhibited by the different plant parts of C. oblonga, with stems showing the higher inhibitory potential. Interestingly, the fruit extracts were the only parts inhibiting the α-glucosidase, with a value of 1.36 mmol acarbose equivalents (ACAE)/g. On the other hand, strong tyrosinase inhibition was found for stems and leaves, being 72.11 and 68.32 mg Kojic acid Equivalent/g, respectively. Finally, a high number of significant (0.05 < p < 0.01) correlations were outlined between phenolics (mainly anthocyanins, flava-3-ols, and tyrosol equivalents) and the different biological assays. Taken together, our findings suggest a potential exploitation of C. oblonga leaves and stems for the food, pharmaceutical, and cosmetic industries.
format Online
Article
Text
id pubmed-8228880
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82288802021-06-26 The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential Zhang, Leilei Rocchetti, Gabriele Zengin, Gökhan Ak, Gunes Saber, Fatema R. Montesano, Domenico Lucini, Luigi Foods Article Cydonia oblonga Mill., normally known as the quince fruit, has been widely used in agro-food industries mainly to produce jams and jellies. However, other parts of the plants are still underutilized and not completely assessed for their nutraceutical profile. Therefore, in this work, the polyphenolic profile of C. oblonga was investigated using an untargeted metabolomics approach based on high-resolution mass spectrometry. Several compounds were identified in the different parts of the plants, including flavonoids (i.e., anthocyanins, flavones, flavan-3-ols, and flavonols), phenolic acids (both hydroxycinnamics and hydroxybenzoics), low-molecular-weight phenolics (tyrosol equivalents), lignans, and stilbenes. Overall, C. oblonga leaves showed the highest in vitro antioxidant potential, as revealed by 2,2-difenil-1-picrylhydrazyl (DPPH), 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric ion reducing antioxidant capacity (CUPRAC) assays, being 189.5, 285.6, 158.9, and 348.8 mg Trolox Equivalent/g, respectively. The enzymes acetyl- and butyryl-cholinesterases were both inhibited by the different plant parts of C. oblonga, with stems showing the higher inhibitory potential. Interestingly, the fruit extracts were the only parts inhibiting the α-glucosidase, with a value of 1.36 mmol acarbose equivalents (ACAE)/g. On the other hand, strong tyrosinase inhibition was found for stems and leaves, being 72.11 and 68.32 mg Kojic acid Equivalent/g, respectively. Finally, a high number of significant (0.05 < p < 0.01) correlations were outlined between phenolics (mainly anthocyanins, flava-3-ols, and tyrosol equivalents) and the different biological assays. Taken together, our findings suggest a potential exploitation of C. oblonga leaves and stems for the food, pharmaceutical, and cosmetic industries. MDPI 2021-05-28 /pmc/articles/PMC8228880/ /pubmed/34071443 http://dx.doi.org/10.3390/foods10061230 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Leilei
Rocchetti, Gabriele
Zengin, Gökhan
Ak, Gunes
Saber, Fatema R.
Montesano, Domenico
Lucini, Luigi
The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential
title The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential
title_full The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential
title_fullStr The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential
title_full_unstemmed The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential
title_short The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential
title_sort uhplc-qtof-ms phenolic profiling and activity of cydonia oblonga mill. reveals a promising nutraceutical potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228880/
https://www.ncbi.nlm.nih.gov/pubmed/34071443
http://dx.doi.org/10.3390/foods10061230
work_keys_str_mv AT zhangleilei theuhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT rocchettigabriele theuhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT zengingokhan theuhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT akgunes theuhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT saberfatemar theuhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT montesanodomenico theuhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT luciniluigi theuhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT zhangleilei uhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT rocchettigabriele uhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT zengingokhan uhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT akgunes uhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT saberfatemar uhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT montesanodomenico uhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential
AT luciniluigi uhplcqtofmsphenolicprofilingandactivityofcydoniaoblongamillrevealsapromisingnutraceuticalpotential