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Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer

Gastric cancer (GC) is the fifth most common cancer globally. Secreted frizzled-related proteins (SFRP) are important elements associated with the Wnt signaling pathway, and its dysregulated expression is found in multiple cancers. However, the function of distinct SFRPs in GC remains poorly underst...

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Autores principales: Liu, Dehua, Sun, Chenyu, Kim, Nahyun, Bhan, Chandur, Tuason, John Pocholo Whitaker, Chen, Yue, Ma, Shaodi, Huang, Yuting, Cheng, Ce, Zhou, Qin, Zhang, Kaiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228899/
https://www.ncbi.nlm.nih.gov/pubmed/34205081
http://dx.doi.org/10.3390/life11060522
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author Liu, Dehua
Sun, Chenyu
Kim, Nahyun
Bhan, Chandur
Tuason, John Pocholo Whitaker
Chen, Yue
Ma, Shaodi
Huang, Yuting
Cheng, Ce
Zhou, Qin
Zhang, Kaiguang
author_facet Liu, Dehua
Sun, Chenyu
Kim, Nahyun
Bhan, Chandur
Tuason, John Pocholo Whitaker
Chen, Yue
Ma, Shaodi
Huang, Yuting
Cheng, Ce
Zhou, Qin
Zhang, Kaiguang
author_sort Liu, Dehua
collection PubMed
description Gastric cancer (GC) is the fifth most common cancer globally. Secreted frizzled-related proteins (SFRP) are important elements associated with the Wnt signaling pathway, and its dysregulated expression is found in multiple cancers. However, the function of distinct SFRPs in GC remains poorly understood. We investigated the differential expression, prognostic value, and immune cell infiltration of SFRPs in gastric cancer patients from the Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, Kaplan–Meier plotter, cBioPortal, STRING, Gene-MANIA, DAVID, MethSurv, and TIMER databases. We found that the expression levels of SFRP2 and SFRP4 were significantly increased in GC tissues, whereas the SFRP1 and SFRP5 expressions were reduced. SFRP1, SFRP2, and SFRP5 were significantly correlated with the clinical cancer stage in GC patients. Higher expression of SFRPs was associated with short overall survival (OS) in GC patients. Besides, high SFRPs methylation showed favorable OS in GC patients. The functions of SFRPs were primarily related to the Wnt signaling pathway, immune system development, and basal cell carcinoma. The expression of SFRPs was strongly correlated with immune infiltrating cells, including CD4+ T cells and macrophages in GC. Our study indicated that SFRPs could be potential targets of precision therapy and prognostic biomarkers for the survival of GC patients.
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spelling pubmed-82288992021-06-26 Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer Liu, Dehua Sun, Chenyu Kim, Nahyun Bhan, Chandur Tuason, John Pocholo Whitaker Chen, Yue Ma, Shaodi Huang, Yuting Cheng, Ce Zhou, Qin Zhang, Kaiguang Life (Basel) Article Gastric cancer (GC) is the fifth most common cancer globally. Secreted frizzled-related proteins (SFRP) are important elements associated with the Wnt signaling pathway, and its dysregulated expression is found in multiple cancers. However, the function of distinct SFRPs in GC remains poorly understood. We investigated the differential expression, prognostic value, and immune cell infiltration of SFRPs in gastric cancer patients from the Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, Kaplan–Meier plotter, cBioPortal, STRING, Gene-MANIA, DAVID, MethSurv, and TIMER databases. We found that the expression levels of SFRP2 and SFRP4 were significantly increased in GC tissues, whereas the SFRP1 and SFRP5 expressions were reduced. SFRP1, SFRP2, and SFRP5 were significantly correlated with the clinical cancer stage in GC patients. Higher expression of SFRPs was associated with short overall survival (OS) in GC patients. Besides, high SFRPs methylation showed favorable OS in GC patients. The functions of SFRPs were primarily related to the Wnt signaling pathway, immune system development, and basal cell carcinoma. The expression of SFRPs was strongly correlated with immune infiltrating cells, including CD4+ T cells and macrophages in GC. Our study indicated that SFRPs could be potential targets of precision therapy and prognostic biomarkers for the survival of GC patients. MDPI 2021-06-03 /pmc/articles/PMC8228899/ /pubmed/34205081 http://dx.doi.org/10.3390/life11060522 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Dehua
Sun, Chenyu
Kim, Nahyun
Bhan, Chandur
Tuason, John Pocholo Whitaker
Chen, Yue
Ma, Shaodi
Huang, Yuting
Cheng, Ce
Zhou, Qin
Zhang, Kaiguang
Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer
title Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer
title_full Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer
title_fullStr Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer
title_full_unstemmed Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer
title_short Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer
title_sort comprehensive analysis of sfrp family members prognostic value and immune infiltration in gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228899/
https://www.ncbi.nlm.nih.gov/pubmed/34205081
http://dx.doi.org/10.3390/life11060522
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