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The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension
Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228947/ https://www.ncbi.nlm.nih.gov/pubmed/34200123 http://dx.doi.org/10.3390/brainsci11060753 |
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author | Moskaleva, Polina V. Shnayder, Natalya A. Petrova, Marina M. Kaskaeva, Daria S. Gavrilyuk, Oksana A. Radostev, Sergey V. Garganeeva, Natalia P. Sharavii, Victoria B. Vaiman, Elena E. Nasyrova, Regina F. |
author_facet | Moskaleva, Polina V. Shnayder, Natalya A. Petrova, Marina M. Kaskaeva, Daria S. Gavrilyuk, Oksana A. Radostev, Sergey V. Garganeeva, Natalia P. Sharavii, Victoria B. Vaiman, Elena E. Nasyrova, Regina F. |
author_sort | Moskaleva, Polina V. |
collection | PubMed |
description | Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15 years using keywords and their combinations. The present review provides a synthesis of information about single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes involved in the development of M and essential AH. The results of studies we have discussed in this review are contradictory, which might be due to different designs of the studies, small sample sizes in some of them, as well as different social and geographical environments. Despite a high prevalence of the M and AH phenotype, its genetic markers have not yet been sufficiently studied. Specifically, there are separate molecular genetic studies aimed to identify SNVs of NOS1, NOS2, and NOS3 genes responsible for the development of M and those responsible for the development of AH. However, these SNVs have not been studied in patients with the phenotype of M and AH. In this review, we identify the SNVs that would be the most interesting to study in this aspect. Understanding the role of environmental factors and genetic predictors will contribute to a better diagnostics and exploration of new approaches to pathogenetic and disease-modifying treatment of the M and AH phenotype. |
format | Online Article Text |
id | pubmed-8228947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82289472021-06-26 The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension Moskaleva, Polina V. Shnayder, Natalya A. Petrova, Marina M. Kaskaeva, Daria S. Gavrilyuk, Oksana A. Radostev, Sergey V. Garganeeva, Natalia P. Sharavii, Victoria B. Vaiman, Elena E. Nasyrova, Regina F. Brain Sci Review Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15 years using keywords and their combinations. The present review provides a synthesis of information about single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes involved in the development of M and essential AH. The results of studies we have discussed in this review are contradictory, which might be due to different designs of the studies, small sample sizes in some of them, as well as different social and geographical environments. Despite a high prevalence of the M and AH phenotype, its genetic markers have not yet been sufficiently studied. Specifically, there are separate molecular genetic studies aimed to identify SNVs of NOS1, NOS2, and NOS3 genes responsible for the development of M and those responsible for the development of AH. However, these SNVs have not been studied in patients with the phenotype of M and AH. In this review, we identify the SNVs that would be the most interesting to study in this aspect. Understanding the role of environmental factors and genetic predictors will contribute to a better diagnostics and exploration of new approaches to pathogenetic and disease-modifying treatment of the M and AH phenotype. MDPI 2021-06-07 /pmc/articles/PMC8228947/ /pubmed/34200123 http://dx.doi.org/10.3390/brainsci11060753 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Moskaleva, Polina V. Shnayder, Natalya A. Petrova, Marina M. Kaskaeva, Daria S. Gavrilyuk, Oksana A. Radostev, Sergey V. Garganeeva, Natalia P. Sharavii, Victoria B. Vaiman, Elena E. Nasyrova, Regina F. The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension |
title | The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension |
title_full | The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension |
title_fullStr | The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension |
title_full_unstemmed | The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension |
title_short | The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension |
title_sort | role of single nucleotide variants of nos1, nos2, and nos3 genes in the development of the phenotype of migraine and arterial hypertension |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228947/ https://www.ncbi.nlm.nih.gov/pubmed/34200123 http://dx.doi.org/10.3390/brainsci11060753 |
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