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Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature

Ovarian malignant germ cell tumors (OMGCT) represent less than 10% of all ovarian tumors. Dysgerminoma is the most common malignant primitive germ cell tumor in young women, known for its curability and low propensity to invade and metastasize when diagnosed early. Herein, we report an unusual type...

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Autores principales: Tîrnovanu, Mihaela Camelia, Florea, Irina Daniela, Tănase, Adina, Toma, Bogdan Florin, Cojocaru, Elena, Ungureanu, Carmen, Lozneanu, Ludmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229055/
https://www.ncbi.nlm.nih.gov/pubmed/34071828
http://dx.doi.org/10.3390/medicina57060534
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author Tîrnovanu, Mihaela Camelia
Florea, Irina Daniela
Tănase, Adina
Toma, Bogdan Florin
Cojocaru, Elena
Ungureanu, Carmen
Lozneanu, Ludmila
author_facet Tîrnovanu, Mihaela Camelia
Florea, Irina Daniela
Tănase, Adina
Toma, Bogdan Florin
Cojocaru, Elena
Ungureanu, Carmen
Lozneanu, Ludmila
author_sort Tîrnovanu, Mihaela Camelia
collection PubMed
description Ovarian malignant germ cell tumors (OMGCT) represent less than 10% of all ovarian tumors. Dysgerminoma is the most common malignant primitive germ cell tumor in young women, known for its curability and low propensity to invade and metastasize when diagnosed early. Herein, we report an unusual type of ovarian dysgerminoma (OD) metastasis with a brief review of the literature, lacking similar reported cases. To our knowledge, although there are several case reports of dysgerminoma metastases with variable anatomic location and presentation, vaginal metastasis has not been previously described. The local or systemic relapse together with local and distant metastasis is considered as an independent predictor of poor survival in patients with OD. In light of the absence of mutations status, our patient successfully responded to therapy. Currently, the patient remains in clinical remission. A specific follow-up plan is ongoing knowing that ovarian dysgerminomas tend to recur most often in the first 2–3 years after treatment.
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spelling pubmed-82290552021-06-26 Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature Tîrnovanu, Mihaela Camelia Florea, Irina Daniela Tănase, Adina Toma, Bogdan Florin Cojocaru, Elena Ungureanu, Carmen Lozneanu, Ludmila Medicina (Kaunas) Case Report Ovarian malignant germ cell tumors (OMGCT) represent less than 10% of all ovarian tumors. Dysgerminoma is the most common malignant primitive germ cell tumor in young women, known for its curability and low propensity to invade and metastasize when diagnosed early. Herein, we report an unusual type of ovarian dysgerminoma (OD) metastasis with a brief review of the literature, lacking similar reported cases. To our knowledge, although there are several case reports of dysgerminoma metastases with variable anatomic location and presentation, vaginal metastasis has not been previously described. The local or systemic relapse together with local and distant metastasis is considered as an independent predictor of poor survival in patients with OD. In light of the absence of mutations status, our patient successfully responded to therapy. Currently, the patient remains in clinical remission. A specific follow-up plan is ongoing knowing that ovarian dysgerminomas tend to recur most often in the first 2–3 years after treatment. MDPI 2021-05-27 /pmc/articles/PMC8229055/ /pubmed/34071828 http://dx.doi.org/10.3390/medicina57060534 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tîrnovanu, Mihaela Camelia
Florea, Irina Daniela
Tănase, Adina
Toma, Bogdan Florin
Cojocaru, Elena
Ungureanu, Carmen
Lozneanu, Ludmila
Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature
title Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature
title_full Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature
title_fullStr Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature
title_full_unstemmed Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature
title_short Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature
title_sort uncommon metastasis of ovarian dysgerminoma: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229055/
https://www.ncbi.nlm.nih.gov/pubmed/34071828
http://dx.doi.org/10.3390/medicina57060534
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