Cargando…

Integrated Proteomic and Metabolomic Analysis of the Testes Characterizes BDE-47-Induced Reproductive Toxicity in Mice

A representative congener of polybrominated diphenyl ethers in the environment, 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47), is associated with male reproductive toxicity, yet the underlying mechanisms remain largely unclear. In this study, mice were administered environmentally relevant concentrati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Liang, Gao, Songyan, Zhao, Hongxia, Wang, Liupeng, Cao, Yiyi, Xi, Jing, Zhang, Xinyu, Dong, Xin, Luan, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229108/ https://www.ncbi.nlm.nih.gov/pubmed/34072909 http://dx.doi.org/10.3390/biom11060821

Ejemplares similares

Metabolomics coupled with pathway analysis characterizes metabolic changes in response to BDE-3 induced reproductive toxicity in mice
por: Wei, Ziheng, et al.
Publicado: (2018)

Placental transfer of the polybrominated diphenyl ethers BDE-47, BDE-99 and BDE-209 in a human placenta perfusion system: an experimental study
por: Frederiksen, Marie, et al.
Publicado: (2010)

Toxicity Effects of Combined Mixtures of BDE-47 and Nickel on the Microalgae Phaeodactylum tricornutum (Bacillariophyceae)
por: Shi, Xiaolai, et al.
Publicado: (2022)

Toxic effects of polybrominated diphenyl ethers (BDE 47 and 99) and localization of BDE-99–induced cyp1a mRNA in zebrafish larvae
por: Yang, Jie, et al.
Publicado: (2017)

Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6
por: Feo, Maria Luisa, et al.
Publicado: (2012)

Triiodothyronine or Antioxidants Block the Inhibitory Effects of BDE-47 and BDE-49 on Axonal Growth in Rat Hippocampal Neuron-Glia Co-Cultures
por: Chen, Hao, et al.
Publicado: (2022)

Characterization of 2,2',4,4'-tetrabromodiphenyl ether (BDE47)-induced testicular toxicity via single-cell RNA-sequencing
por: Zhang, Wei, et al.
Publicado: (2022)

Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency
por: McIntyre, Rebecca L, et al.
Publicado: (2015)

Metabolic Consequences of Developmental Exposure to Polystyrene Nanoplastics, the Flame Retardant BDE-47 and Their Combination in Zebrafish
por: Chackal, Raphaël, et al.
Publicado: (2022)

Mitteilungen des BDE
Publicado: (2020)

Mitteilungen des BDE
Publicado: (2020)

Mitteilungen des BDE
Publicado: (2021)

Mitteilungen des BDE
Publicado: (2021)

Mitteilungen des BDE
Publicado: (2021)

Mitteilungen des BDE
Publicado: (2022)

Mitteilungen des BDE
Publicado: (2021)

Mitteilungen des BDE
Publicado: (2021)

Mitteilungen des BDE
Publicado: (2022)

Mitteilungen des BDE
Publicado: (2022)

Toxic effects of decabromodiphenyl ether (BDE-209) on human embryonic kidney cells
por: Li, Min, et al.
Publicado: (2014)

Hydroxylation Increases the Neurotoxic Potential of BDE-47 to Affect Exocytosis and Calcium Homeostasis in PC12 Cells
por: Dingemans, Milou M.L., et al.
Publicado: (2008)

High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
por: Petreas, Myrto, et al.
Publicado: (2003)

Transcriptional and Epigenetic Mechanisms Underlying Enhanced in Vitro Adipocyte Differentiation by the Brominated Flame Retardant BDE-47
por: Kamstra, Jorke H., et al.
Publicado: (2014)

BDE-47 Induces Mitochondrial Dysfunction and Endoplasmic Reticulum Stress to Inhibit Early Porcine Embryonic Development
por: Liu, Rong-Ping, et al.
Publicado: (2023)

Transcriptomic Analysis of Gonadal Adipose Tissue in Male Mice Exposed Perinatally to 2,2′,4,4′-Tetrabromodiphenyl Ether (BDE-47)
por: Abrha, Aser, et al.
Publicado: (2018)

BDE-47, -99, -209 and Their Ternary Mixture Disrupt Glucose and Lipid Metabolism of Hepg2 Cells at Dietary Relevant Concentrations: Mechanistic Insight through Integrated Transcriptomics and Proteomics Analysis
por: Casella, Marialuisa, et al.
Publicado: (2022)

An Integrated Proteomics and Metabolomics Strategy for the Mechanism of Calcium Oxalate Crystal-Induced Kidney Injury
por: Gao, Songyan, et al.
Publicado: (2022)

Purine Metabolism and Pyrimidine Metabolism Alteration Is a Potential Mechanism of BDE-47-Induced Apoptosis in Marine Rotifer Brachionus plicatilis
por: Cao, Sai, et al.
Publicado: (2023)

Cerebral gene expression and neurobehavioural development after perinatal exposure to an environmentally relevant polybrominated diphenylether (BDE47)
por: Haave, Marte, et al.
Publicado: (2011)

Uptake and biotransformation of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) in four marine microalgae species
por: Po, Beverly H. K., et al.
Publicado: (2017)

BDE47 induces rat CYP3A1 by targeting the transcriptional regulation of miR-23b
por: Sun, Zhenzhen, et al.
Publicado: (2016)

Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity
por: Huang, Qingyu, et al.
Publicado: (2016)

Neonatal Exposure to Brominated Flame Retardant BDE-47 Reduces Long-Term Potentiation and Postsynaptic Protein Levels in Mouse Hippocampus
por: Dingemans, Milou M.L., et al.
Publicado: (2007)

Bromination Pattern of Hydroxylated Metabolites of BDE-47 Affects Their Potency to Release Calcium from Intracellular Stores in PC12 Cells
por: Dingemans, Milou M.L., et al.
Publicado: (2010)

The PBDE metabolite 6-OH-BDE 47 affects melanin pigmentation and THRβ MRNA expression in the eye of zebrafish embryos
por: Dong, Wu, et al.
Publicado: (2014)

The Regulatory Roles of MicroRNA in Effects of 2,2'4,4'-Tetrabromodiphenyl Ether (BDE47) on the Transcriptome of Zebrafish Larvae
por: Zhao, Jing, et al.
Publicado: (2017)

Persistent 6-OH-BDE-47 exposure impairs functional neuronal maturation and alters expression of neurodevelopmentally-relevant chromatin remodelers
por: Poston, Robert G, et al.
Publicado: (2018)

BDE-47 Induces Immunotoxicity in RAW264.7 Macrophages through the Reactive Oxygen Species-Mediated Mitochondrial Apoptotic Pathway
por: Gao, Qian, et al.
Publicado: (2023)

Gender-specific modulation of immune system complement gene expression in marine medaka Oryzias melastigma following dietary exposure of BDE-47
por: Ye, Roy R., et al.
Publicado: (2012)

Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling
por: Shan, Qun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_63st5nur806b3430u8njgoi77f