Cargando…
Early Life Wheeze and Risk Factors for Asthma—A Revisit at Age 7 in the GEWAC-Cohort
One third of all toddlers are in need of medical care because of acute wheeze and many of these children have persistent asthma at school age. Our aims were to assess risk factors for and the prevalence of asthma at age 7 in a cohort of children suffering from an acute wheezing episode as toddlers....
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229161/ https://www.ncbi.nlm.nih.gov/pubmed/34201058 http://dx.doi.org/10.3390/children8060488 |
_version_ | 1783712912283533312 |
---|---|
author | Holmdahl, Idun Filiou, Anastasia Stenberg Hammar, Katarina Asarnoj, Anna Borres, Magnus P. van Hage, Marianne Hedlin, Gunilla Söderhäll, Cilla Konradsen, Jon R. |
author_facet | Holmdahl, Idun Filiou, Anastasia Stenberg Hammar, Katarina Asarnoj, Anna Borres, Magnus P. van Hage, Marianne Hedlin, Gunilla Söderhäll, Cilla Konradsen, Jon R. |
author_sort | Holmdahl, Idun |
collection | PubMed |
description | One third of all toddlers are in need of medical care because of acute wheeze and many of these children have persistent asthma at school age. Our aims were to assess risk factors for and the prevalence of asthma at age 7 in a cohort of children suffering from an acute wheezing episode as toddlers. A total of 113 children, included during an acute wheezing episode (cases), and 54 healthy controls were followed prospectively from early pre-school age to 7 years. The protocol included questionnaires, ACT, FeNO, nasopharyngeal virus samples, blood sampling for cell count, vitamin D levels, and IgE to food and airborne allergens. The prevalence of asthma at age 7 was 70.8% among cases and 1.9% among controls (p < 0.001). Acute wheeze caused by rhinovirus (RV) infection at inclusion was more common among cases with asthma at age 7 compared to cases without asthma (p = 0.011) and this association remained significant following adjustment for infection with other viruses (OR 3.8, 95% CI 1.4–10.5). Cases with asthma at age 7 had been admitted to hospital more often (p = 0.024) and spent more days admitted (p = 0.01) during the year following inclusion compared to cases without asthma. RV infection stands out as the main associated factor for wheeze evolving to persistent asthma. Cases who developed asthma also had an increased need of hospital time and care for wheeze during the year after inclusion. |
format | Online Article Text |
id | pubmed-8229161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82291612021-06-26 Early Life Wheeze and Risk Factors for Asthma—A Revisit at Age 7 in the GEWAC-Cohort Holmdahl, Idun Filiou, Anastasia Stenberg Hammar, Katarina Asarnoj, Anna Borres, Magnus P. van Hage, Marianne Hedlin, Gunilla Söderhäll, Cilla Konradsen, Jon R. Children (Basel) Article One third of all toddlers are in need of medical care because of acute wheeze and many of these children have persistent asthma at school age. Our aims were to assess risk factors for and the prevalence of asthma at age 7 in a cohort of children suffering from an acute wheezing episode as toddlers. A total of 113 children, included during an acute wheezing episode (cases), and 54 healthy controls were followed prospectively from early pre-school age to 7 years. The protocol included questionnaires, ACT, FeNO, nasopharyngeal virus samples, blood sampling for cell count, vitamin D levels, and IgE to food and airborne allergens. The prevalence of asthma at age 7 was 70.8% among cases and 1.9% among controls (p < 0.001). Acute wheeze caused by rhinovirus (RV) infection at inclusion was more common among cases with asthma at age 7 compared to cases without asthma (p = 0.011) and this association remained significant following adjustment for infection with other viruses (OR 3.8, 95% CI 1.4–10.5). Cases with asthma at age 7 had been admitted to hospital more often (p = 0.024) and spent more days admitted (p = 0.01) during the year following inclusion compared to cases without asthma. RV infection stands out as the main associated factor for wheeze evolving to persistent asthma. Cases who developed asthma also had an increased need of hospital time and care for wheeze during the year after inclusion. MDPI 2021-06-08 /pmc/articles/PMC8229161/ /pubmed/34201058 http://dx.doi.org/10.3390/children8060488 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Holmdahl, Idun Filiou, Anastasia Stenberg Hammar, Katarina Asarnoj, Anna Borres, Magnus P. van Hage, Marianne Hedlin, Gunilla Söderhäll, Cilla Konradsen, Jon R. Early Life Wheeze and Risk Factors for Asthma—A Revisit at Age 7 in the GEWAC-Cohort |
title | Early Life Wheeze and Risk Factors for Asthma—A Revisit at Age 7 in the GEWAC-Cohort |
title_full | Early Life Wheeze and Risk Factors for Asthma—A Revisit at Age 7 in the GEWAC-Cohort |
title_fullStr | Early Life Wheeze and Risk Factors for Asthma—A Revisit at Age 7 in the GEWAC-Cohort |
title_full_unstemmed | Early Life Wheeze and Risk Factors for Asthma—A Revisit at Age 7 in the GEWAC-Cohort |
title_short | Early Life Wheeze and Risk Factors for Asthma—A Revisit at Age 7 in the GEWAC-Cohort |
title_sort | early life wheeze and risk factors for asthma—a revisit at age 7 in the gewac-cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229161/ https://www.ncbi.nlm.nih.gov/pubmed/34201058 http://dx.doi.org/10.3390/children8060488 |
work_keys_str_mv | AT holmdahlidun earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort AT filiouanastasia earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort AT stenberghammarkatarina earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort AT asarnojanna earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort AT borresmagnusp earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort AT vanhagemarianne earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort AT hedlingunilla earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort AT soderhallcilla earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort AT konradsenjonr earlylifewheezeandriskfactorsforasthmaarevisitatage7inthegewaccohort |