Cargando…
Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics
This study aimed to determine the association between suicidal behavior and T. gondii seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against T. gondii were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individ...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229255/ https://www.ncbi.nlm.nih.gov/pubmed/34070892 http://dx.doi.org/10.3390/pathogens10060677 |
_version_ | 1783712934411632640 |
---|---|
author | Alvarado-Esquivel, Cosme Estrada-Martínez, Sergio Ramos-Nevárez, Agar Pérez-Álamos, Alma Rosa Beristain-García, Isabel Alvarado-Félix, Ángel Osvaldo Cerrillo-Soto, Sandra Margarita Sifuentes-Álvarez, Antonio Alvarado-Félix, Gustavo Alexis Guido-Arreola, Carlos Alberto Saenz-Soto, Leandro |
author_facet | Alvarado-Esquivel, Cosme Estrada-Martínez, Sergio Ramos-Nevárez, Agar Pérez-Álamos, Alma Rosa Beristain-García, Isabel Alvarado-Félix, Ángel Osvaldo Cerrillo-Soto, Sandra Margarita Sifuentes-Álvarez, Antonio Alvarado-Félix, Gustavo Alexis Guido-Arreola, Carlos Alberto Saenz-Soto, Leandro |
author_sort | Alvarado-Esquivel, Cosme |
collection | PubMed |
description | This study aimed to determine the association between suicidal behavior and T. gondii seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against T. gondii were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individuals without this history (OR: 1.64; 95% CI: 1.11–2.42; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 1.56; 95% CI: 1.01–2.42; p = 0.03) and individuals aged ≤30 years (OR: 3.25; 95% CI: 1.53–6.88; p = 0.001). No association between the rates of high (>150 IU/mL) levels of anti-T. gondii IgG antibodies and suicidal ideation or suicide attempts was found. IgG antibodies against T. gondii were found in 22 of 185 (11.9%) individuals with a history of suicide attempts and in 149 (8.0%) of 1860 individuals without this history (OR: 1.54; 95% CI: 0.96–2.49; p = 0.06). The seroprevalence of T. gondii infection was associated with suicide attempts in individuals aged 31–50 years (OR: 2.01; 95% CI: 1.09–3.71; p = 0.02), and with more than three suicide attempts (OR: 4.02; 95% CI: 1.34–12.03; p = 0.008). Our results indicate that T. gondii exposure is associated with suicidal behavior among patients attending primary care clinics. |
format | Online Article Text |
id | pubmed-8229255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82292552021-06-26 Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics Alvarado-Esquivel, Cosme Estrada-Martínez, Sergio Ramos-Nevárez, Agar Pérez-Álamos, Alma Rosa Beristain-García, Isabel Alvarado-Félix, Ángel Osvaldo Cerrillo-Soto, Sandra Margarita Sifuentes-Álvarez, Antonio Alvarado-Félix, Gustavo Alexis Guido-Arreola, Carlos Alberto Saenz-Soto, Leandro Pathogens Article This study aimed to determine the association between suicidal behavior and T. gondii seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against T. gondii were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individuals without this history (OR: 1.64; 95% CI: 1.11–2.42; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 1.56; 95% CI: 1.01–2.42; p = 0.03) and individuals aged ≤30 years (OR: 3.25; 95% CI: 1.53–6.88; p = 0.001). No association between the rates of high (>150 IU/mL) levels of anti-T. gondii IgG antibodies and suicidal ideation or suicide attempts was found. IgG antibodies against T. gondii were found in 22 of 185 (11.9%) individuals with a history of suicide attempts and in 149 (8.0%) of 1860 individuals without this history (OR: 1.54; 95% CI: 0.96–2.49; p = 0.06). The seroprevalence of T. gondii infection was associated with suicide attempts in individuals aged 31–50 years (OR: 2.01; 95% CI: 1.09–3.71; p = 0.02), and with more than three suicide attempts (OR: 4.02; 95% CI: 1.34–12.03; p = 0.008). Our results indicate that T. gondii exposure is associated with suicidal behavior among patients attending primary care clinics. MDPI 2021-05-30 /pmc/articles/PMC8229255/ /pubmed/34070892 http://dx.doi.org/10.3390/pathogens10060677 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alvarado-Esquivel, Cosme Estrada-Martínez, Sergio Ramos-Nevárez, Agar Pérez-Álamos, Alma Rosa Beristain-García, Isabel Alvarado-Félix, Ángel Osvaldo Cerrillo-Soto, Sandra Margarita Sifuentes-Álvarez, Antonio Alvarado-Félix, Gustavo Alexis Guido-Arreola, Carlos Alberto Saenz-Soto, Leandro Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
title | Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
title_full | Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
title_fullStr | Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
title_full_unstemmed | Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
title_short | Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics |
title_sort | association between toxoplasma gondii exposure and suicidal behavior in patients attending primary health care clinics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229255/ https://www.ncbi.nlm.nih.gov/pubmed/34070892 http://dx.doi.org/10.3390/pathogens10060677 |
work_keys_str_mv | AT alvaradoesquivelcosme associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT estradamartinezsergio associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT ramosnevarezagar associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT perezalamosalmarosa associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT beristaingarciaisabel associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT alvaradofelixangelosvaldo associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT cerrillosotosandramargarita associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT sifuentesalvarezantonio associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT alvaradofelixgustavoalexis associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT guidoarreolacarlosalberto associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics AT saenzsotoleandro associationbetweentoxoplasmagondiiexposureandsuicidalbehaviorinpatientsattendingprimaryhealthcareclinics |