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Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics

This study aimed to determine the association between suicidal behavior and T. gondii seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against T. gondii were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individ...

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Autores principales: Alvarado-Esquivel, Cosme, Estrada-Martínez, Sergio, Ramos-Nevárez, Agar, Pérez-Álamos, Alma Rosa, Beristain-García, Isabel, Alvarado-Félix, Ángel Osvaldo, Cerrillo-Soto, Sandra Margarita, Sifuentes-Álvarez, Antonio, Alvarado-Félix, Gustavo Alexis, Guido-Arreola, Carlos Alberto, Saenz-Soto, Leandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229255/
https://www.ncbi.nlm.nih.gov/pubmed/34070892
http://dx.doi.org/10.3390/pathogens10060677
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author Alvarado-Esquivel, Cosme
Estrada-Martínez, Sergio
Ramos-Nevárez, Agar
Pérez-Álamos, Alma Rosa
Beristain-García, Isabel
Alvarado-Félix, Ángel Osvaldo
Cerrillo-Soto, Sandra Margarita
Sifuentes-Álvarez, Antonio
Alvarado-Félix, Gustavo Alexis
Guido-Arreola, Carlos Alberto
Saenz-Soto, Leandro
author_facet Alvarado-Esquivel, Cosme
Estrada-Martínez, Sergio
Ramos-Nevárez, Agar
Pérez-Álamos, Alma Rosa
Beristain-García, Isabel
Alvarado-Félix, Ángel Osvaldo
Cerrillo-Soto, Sandra Margarita
Sifuentes-Álvarez, Antonio
Alvarado-Félix, Gustavo Alexis
Guido-Arreola, Carlos Alberto
Saenz-Soto, Leandro
author_sort Alvarado-Esquivel, Cosme
collection PubMed
description This study aimed to determine the association between suicidal behavior and T. gondii seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against T. gondii were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individuals without this history (OR: 1.64; 95% CI: 1.11–2.42; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 1.56; 95% CI: 1.01–2.42; p = 0.03) and individuals aged ≤30 years (OR: 3.25; 95% CI: 1.53–6.88; p = 0.001). No association between the rates of high (>150 IU/mL) levels of anti-T. gondii IgG antibodies and suicidal ideation or suicide attempts was found. IgG antibodies against T. gondii were found in 22 of 185 (11.9%) individuals with a history of suicide attempts and in 149 (8.0%) of 1860 individuals without this history (OR: 1.54; 95% CI: 0.96–2.49; p = 0.06). The seroprevalence of T. gondii infection was associated with suicide attempts in individuals aged 31–50 years (OR: 2.01; 95% CI: 1.09–3.71; p = 0.02), and with more than three suicide attempts (OR: 4.02; 95% CI: 1.34–12.03; p = 0.008). Our results indicate that T. gondii exposure is associated with suicidal behavior among patients attending primary care clinics.
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spelling pubmed-82292552021-06-26 Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics Alvarado-Esquivel, Cosme Estrada-Martínez, Sergio Ramos-Nevárez, Agar Pérez-Álamos, Alma Rosa Beristain-García, Isabel Alvarado-Félix, Ángel Osvaldo Cerrillo-Soto, Sandra Margarita Sifuentes-Álvarez, Antonio Alvarado-Félix, Gustavo Alexis Guido-Arreola, Carlos Alberto Saenz-Soto, Leandro Pathogens Article This study aimed to determine the association between suicidal behavior and T. gondii seroreactivity in 2045 patients attending primary care clinics. IgG antibodies against T. gondii were found in 37 (12.1%) out of 306 individuals with a history of suicidal ideation and in 134 (7.7%) of 1739 individuals without this history (OR: 1.64; 95% CI: 1.11–2.42; p = 0.01). Seropositivity to T. gondii was associated with suicidal ideation in women (OR: 1.56; 95% CI: 1.01–2.42; p = 0.03) and individuals aged ≤30 years (OR: 3.25; 95% CI: 1.53–6.88; p = 0.001). No association between the rates of high (>150 IU/mL) levels of anti-T. gondii IgG antibodies and suicidal ideation or suicide attempts was found. IgG antibodies against T. gondii were found in 22 of 185 (11.9%) individuals with a history of suicide attempts and in 149 (8.0%) of 1860 individuals without this history (OR: 1.54; 95% CI: 0.96–2.49; p = 0.06). The seroprevalence of T. gondii infection was associated with suicide attempts in individuals aged 31–50 years (OR: 2.01; 95% CI: 1.09–3.71; p = 0.02), and with more than three suicide attempts (OR: 4.02; 95% CI: 1.34–12.03; p = 0.008). Our results indicate that T. gondii exposure is associated with suicidal behavior among patients attending primary care clinics. MDPI 2021-05-30 /pmc/articles/PMC8229255/ /pubmed/34070892 http://dx.doi.org/10.3390/pathogens10060677 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alvarado-Esquivel, Cosme
Estrada-Martínez, Sergio
Ramos-Nevárez, Agar
Pérez-Álamos, Alma Rosa
Beristain-García, Isabel
Alvarado-Félix, Ángel Osvaldo
Cerrillo-Soto, Sandra Margarita
Sifuentes-Álvarez, Antonio
Alvarado-Félix, Gustavo Alexis
Guido-Arreola, Carlos Alberto
Saenz-Soto, Leandro
Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics
title Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics
title_full Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics
title_fullStr Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics
title_full_unstemmed Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics
title_short Association between Toxoplasma gondii Exposure and Suicidal Behavior in Patients Attending Primary Health Care Clinics
title_sort association between toxoplasma gondii exposure and suicidal behavior in patients attending primary health care clinics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229255/
https://www.ncbi.nlm.nih.gov/pubmed/34070892
http://dx.doi.org/10.3390/pathogens10060677
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