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The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants
AIMS: The study investigated a putative association between early-onset-sepsis (EOS) and poor neurodevelopmental outcomes at 2 years corrected age in very low birth weight infants. METHODS: This was a single-center cohort study on infants weighing less than 1500 g with a gestational age below 35 wee...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229301/ https://www.ncbi.nlm.nih.gov/pubmed/34172028 http://dx.doi.org/10.1186/s12887-021-02738-5 |
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author | Ortgies, Tjark Rullmann, Michael Ziegelhöfer, Dorothée Bläser, Annett Thome, Ulrich H. |
author_facet | Ortgies, Tjark Rullmann, Michael Ziegelhöfer, Dorothée Bläser, Annett Thome, Ulrich H. |
author_sort | Ortgies, Tjark |
collection | PubMed |
description | AIMS: The study investigated a putative association between early-onset-sepsis (EOS) and poor neurodevelopmental outcomes at 2 years corrected age in very low birth weight infants. METHODS: This was a single-center cohort study on infants weighing less than 1500 g with a gestational age below 35 weeks at birth born between 2008 and 2011. Neurodevelopmental outcomes were assessed at follow-up with the Bayley Scales of Infant Development-II. EOS was defined as either culture-proven EOS or clinical EOS using blood culture, CrP levels, and clinical symptoms and treatment. Neurodevelopmental impairment (NDI) was defined as one or more of the following: Mental Developmental Index (MDI) and/or Psychomotor Developmental Index (PDI) scores lower than 70; presence of cerebral palsy. RESULTS: Of 405 eligible newborns in the study period 166 were included. Two had culture-proven and 29 clinical EOS. Median MDI scores in patients with EOS were 96 (IQR: 86–106) and in the control group 94 (84–106, p = 0.77). PDI scores in patients with EOS were 96 (86–106) and in the control group 99,5 (92–103, p = 0.03). Of infected patients 7/31 (24%) showed NDI as defined, whereas only 11/135 (8%) showed NDI in the control group (OR 3.3, p = 0.03). Multiple regression analyses identified chorioamnionitis and poor CRIB-Scores as individual risk factors for MDI or PDI values < 70. CONCLUSION: In our study, EOS among VLBW-infants significantly impaired the neurodevelopment at 2 years corrected age. As shown in previous reports infection continues to be a problem and strategies for a reduction need further improvement. |
format | Online Article Text |
id | pubmed-8229301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82293012021-06-28 The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants Ortgies, Tjark Rullmann, Michael Ziegelhöfer, Dorothée Bläser, Annett Thome, Ulrich H. BMC Pediatr Research AIMS: The study investigated a putative association between early-onset-sepsis (EOS) and poor neurodevelopmental outcomes at 2 years corrected age in very low birth weight infants. METHODS: This was a single-center cohort study on infants weighing less than 1500 g with a gestational age below 35 weeks at birth born between 2008 and 2011. Neurodevelopmental outcomes were assessed at follow-up with the Bayley Scales of Infant Development-II. EOS was defined as either culture-proven EOS or clinical EOS using blood culture, CrP levels, and clinical symptoms and treatment. Neurodevelopmental impairment (NDI) was defined as one or more of the following: Mental Developmental Index (MDI) and/or Psychomotor Developmental Index (PDI) scores lower than 70; presence of cerebral palsy. RESULTS: Of 405 eligible newborns in the study period 166 were included. Two had culture-proven and 29 clinical EOS. Median MDI scores in patients with EOS were 96 (IQR: 86–106) and in the control group 94 (84–106, p = 0.77). PDI scores in patients with EOS were 96 (86–106) and in the control group 99,5 (92–103, p = 0.03). Of infected patients 7/31 (24%) showed NDI as defined, whereas only 11/135 (8%) showed NDI in the control group (OR 3.3, p = 0.03). Multiple regression analyses identified chorioamnionitis and poor CRIB-Scores as individual risk factors for MDI or PDI values < 70. CONCLUSION: In our study, EOS among VLBW-infants significantly impaired the neurodevelopment at 2 years corrected age. As shown in previous reports infection continues to be a problem and strategies for a reduction need further improvement. BioMed Central 2021-06-25 /pmc/articles/PMC8229301/ /pubmed/34172028 http://dx.doi.org/10.1186/s12887-021-02738-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Ortgies, Tjark Rullmann, Michael Ziegelhöfer, Dorothée Bläser, Annett Thome, Ulrich H. The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
title | The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
title_full | The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
title_fullStr | The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
title_full_unstemmed | The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
title_short | The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
title_sort | role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229301/ https://www.ncbi.nlm.nih.gov/pubmed/34172028 http://dx.doi.org/10.1186/s12887-021-02738-5 |
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