Cargando…

Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease

Accurate assessment of Parkinson’s disease (PD) ON and OFF states in the usual environment is essential for tailoring optimal treatments. Wearables facilitate measurements of gait in novel and unsupervised environments; however, differences between unsupervised and in-laboratory measures have been r...

Descripción completa

Detalles Bibliográficos
Autores principales: Corrà, Marta Francisca, Atrsaei, Arash, Sardoreira, Ana, Hansen, Clint, Aminian, Kamiar, Correia, Manuel, Vila-Chã, Nuno, Maetzler, Walter, Maia, Luís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229328/
https://www.ncbi.nlm.nih.gov/pubmed/34207565
http://dx.doi.org/10.3390/s21123974
_version_ 1783712951931240448
author Corrà, Marta Francisca
Atrsaei, Arash
Sardoreira, Ana
Hansen, Clint
Aminian, Kamiar
Correia, Manuel
Vila-Chã, Nuno
Maetzler, Walter
Maia, Luís
author_facet Corrà, Marta Francisca
Atrsaei, Arash
Sardoreira, Ana
Hansen, Clint
Aminian, Kamiar
Correia, Manuel
Vila-Chã, Nuno
Maetzler, Walter
Maia, Luís
author_sort Corrà, Marta Francisca
collection PubMed
description Accurate assessment of Parkinson’s disease (PD) ON and OFF states in the usual environment is essential for tailoring optimal treatments. Wearables facilitate measurements of gait in novel and unsupervised environments; however, differences between unsupervised and in-laboratory measures have been reported in PD. We aimed to investigate whether unsupervised gait speed discriminates medication states and which supervised tests most accurately represent home performance. In-lab gait speeds from different gait tasks were compared to home speeds of 27 PD patients at ON and OFF states using inertial sensors. Daily gait speed distribution was expressed in percentiles and walking bout (WB) length. Gait speeds differentiated ON and OFF states in the lab and the home. When comparing lab with home performance, ON assessments in the lab showed moderate-to-high correlations with faster gait speeds in unsupervised environment (r = 0.69; p < 0.001), associated with long WB. OFF gait assessments in the lab showed moderate correlation values with slow gait speeds during OFF state at home (r = 0.56; p = 0.004), associated with short WB. In-lab and daily assessments of gait speed with wearables capture additional integrative aspects of PD, reflecting different aspects of mobility. Unsupervised assessment using wearables adds complementary information to the clinical assessment of motor fluctuations in PD.
format Online
Article
Text
id pubmed-8229328
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82293282021-06-26 Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease Corrà, Marta Francisca Atrsaei, Arash Sardoreira, Ana Hansen, Clint Aminian, Kamiar Correia, Manuel Vila-Chã, Nuno Maetzler, Walter Maia, Luís Sensors (Basel) Article Accurate assessment of Parkinson’s disease (PD) ON and OFF states in the usual environment is essential for tailoring optimal treatments. Wearables facilitate measurements of gait in novel and unsupervised environments; however, differences between unsupervised and in-laboratory measures have been reported in PD. We aimed to investigate whether unsupervised gait speed discriminates medication states and which supervised tests most accurately represent home performance. In-lab gait speeds from different gait tasks were compared to home speeds of 27 PD patients at ON and OFF states using inertial sensors. Daily gait speed distribution was expressed in percentiles and walking bout (WB) length. Gait speeds differentiated ON and OFF states in the lab and the home. When comparing lab with home performance, ON assessments in the lab showed moderate-to-high correlations with faster gait speeds in unsupervised environment (r = 0.69; p < 0.001), associated with long WB. OFF gait assessments in the lab showed moderate correlation values with slow gait speeds during OFF state at home (r = 0.56; p = 0.004), associated with short WB. In-lab and daily assessments of gait speed with wearables capture additional integrative aspects of PD, reflecting different aspects of mobility. Unsupervised assessment using wearables adds complementary information to the clinical assessment of motor fluctuations in PD. MDPI 2021-06-09 /pmc/articles/PMC8229328/ /pubmed/34207565 http://dx.doi.org/10.3390/s21123974 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Corrà, Marta Francisca
Atrsaei, Arash
Sardoreira, Ana
Hansen, Clint
Aminian, Kamiar
Correia, Manuel
Vila-Chã, Nuno
Maetzler, Walter
Maia, Luís
Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease
title Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease
title_full Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease
title_fullStr Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease
title_full_unstemmed Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease
title_short Comparison of Laboratory and Daily-Life Gait Speed Assessment during ON and OFF States in Parkinson’s Disease
title_sort comparison of laboratory and daily-life gait speed assessment during on and off states in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229328/
https://www.ncbi.nlm.nih.gov/pubmed/34207565
http://dx.doi.org/10.3390/s21123974
work_keys_str_mv AT corramartafrancisca comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease
AT atrsaeiarash comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease
AT sardoreiraana comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease
AT hansenclint comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease
AT aminiankamiar comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease
AT correiamanuel comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease
AT vilachanuno comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease
AT maetzlerwalter comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease
AT maialuis comparisonoflaboratoryanddailylifegaitspeedassessmentduringonandoffstatesinparkinsonsdisease