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A community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 2: an uncommon event, Italy, August to October 2018

In September 2018 in Brescia province, northern Italy, an outbreak of Legionnaires' disease (LD) caused by Legionella pneumophila serogroup 2 (Lp2) occurred. The 33 cases (two fatal) resided in seven municipalities along the Chiese river. All cases were negative by urinary antigen test (UAT) an...

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Autores principales: Scaturro, Maria, Rota, Maria Cristina, Caporali, Maria Grazia, Girolamo, Antonietta, Magoni, Michele, Barberis, Daria, Romano, Chiara, Cereda, Danilo, Gramegna, Maria, Piro, Antonio, Corbellini, Silvia, Giagulli, Cinzia, Rezza, Giovanni, Caruso, Arnaldo, Ricci, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229375/
https://www.ncbi.nlm.nih.gov/pubmed/34169820
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.25.2001961
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author Scaturro, Maria
Rota, Maria Cristina
Caporali, Maria Grazia
Girolamo, Antonietta
Magoni, Michele
Barberis, Daria
Romano, Chiara
Cereda, Danilo
Gramegna, Maria
Piro, Antonio
Corbellini, Silvia
Giagulli, Cinzia
Rezza, Giovanni
Caruso, Arnaldo
Ricci, Maria Luisa
author_facet Scaturro, Maria
Rota, Maria Cristina
Caporali, Maria Grazia
Girolamo, Antonietta
Magoni, Michele
Barberis, Daria
Romano, Chiara
Cereda, Danilo
Gramegna, Maria
Piro, Antonio
Corbellini, Silvia
Giagulli, Cinzia
Rezza, Giovanni
Caruso, Arnaldo
Ricci, Maria Luisa
author_sort Scaturro, Maria
collection PubMed
description In September 2018 in Brescia province, northern Italy, an outbreak of Legionnaires' disease (LD) caused by Legionella pneumophila serogroup 2 (Lp2) occurred. The 33 cases (two fatal) resided in seven municipalities along the Chiese river. All cases were negative by urinary antigen test (UAT) and most were diagnosed by real-time PCR and serology. In only three cases, respiratory sample cultures were positive, and Lp2 was identified and typed as sequence type (ST)1455. In another three cases, nested sequence-based typing was directly applied to respiratory samples, which provided allelic profiles highly similar to ST1455. An environmental investigation was undertaken immediately and water samples were collected from private homes, municipal water systems, cooling towers and the river. Overall, 533 environmental water samples were analysed and 34 were positive for Lp. Of these, only three samples, all collected from the Chiese river, were Lp2 ST1455. If and how the river water could have been aerosolised causing the LD cases remains unexplained. This outbreak, the first to our knowledge caused by Lp2, highlights the limits of UAT for LD diagnosis, underlining the importance of adopting multiple tests to ensure that serogroups other than serogroup 1, as well as other Legionella species, are identified.
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spelling pubmed-82293752021-07-02 A community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 2: an uncommon event, Italy, August to October 2018 Scaturro, Maria Rota, Maria Cristina Caporali, Maria Grazia Girolamo, Antonietta Magoni, Michele Barberis, Daria Romano, Chiara Cereda, Danilo Gramegna, Maria Piro, Antonio Corbellini, Silvia Giagulli, Cinzia Rezza, Giovanni Caruso, Arnaldo Ricci, Maria Luisa Euro Surveill Outbreaks In September 2018 in Brescia province, northern Italy, an outbreak of Legionnaires' disease (LD) caused by Legionella pneumophila serogroup 2 (Lp2) occurred. The 33 cases (two fatal) resided in seven municipalities along the Chiese river. All cases were negative by urinary antigen test (UAT) and most were diagnosed by real-time PCR and serology. In only three cases, respiratory sample cultures were positive, and Lp2 was identified and typed as sequence type (ST)1455. In another three cases, nested sequence-based typing was directly applied to respiratory samples, which provided allelic profiles highly similar to ST1455. An environmental investigation was undertaken immediately and water samples were collected from private homes, municipal water systems, cooling towers and the river. Overall, 533 environmental water samples were analysed and 34 were positive for Lp. Of these, only three samples, all collected from the Chiese river, were Lp2 ST1455. If and how the river water could have been aerosolised causing the LD cases remains unexplained. This outbreak, the first to our knowledge caused by Lp2, highlights the limits of UAT for LD diagnosis, underlining the importance of adopting multiple tests to ensure that serogroups other than serogroup 1, as well as other Legionella species, are identified. European Centre for Disease Prevention and Control (ECDC) 2021-06-24 /pmc/articles/PMC8229375/ /pubmed/34169820 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.25.2001961 Text en This article is copyright of the authors or their affiliated institutions, 2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Outbreaks
Scaturro, Maria
Rota, Maria Cristina
Caporali, Maria Grazia
Girolamo, Antonietta
Magoni, Michele
Barberis, Daria
Romano, Chiara
Cereda, Danilo
Gramegna, Maria
Piro, Antonio
Corbellini, Silvia
Giagulli, Cinzia
Rezza, Giovanni
Caruso, Arnaldo
Ricci, Maria Luisa
A community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 2: an uncommon event, Italy, August to October 2018
title A community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 2: an uncommon event, Italy, August to October 2018
title_full A community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 2: an uncommon event, Italy, August to October 2018
title_fullStr A community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 2: an uncommon event, Italy, August to October 2018
title_full_unstemmed A community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 2: an uncommon event, Italy, August to October 2018
title_short A community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 2: an uncommon event, Italy, August to October 2018
title_sort community-acquired legionnaires’ disease outbreak caused by legionella pneumophila serogroup 2: an uncommon event, italy, august to october 2018
topic Outbreaks
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229375/
https://www.ncbi.nlm.nih.gov/pubmed/34169820
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.25.2001961
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