Parvaxanthines D–F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva

Five new compounds including three pairs of enantiomeric xanthine analogues, parvaxanthines D–F (1–3), two new guanosine derivatives, asponguanosines C and D (6 and 7), along with two known adenine derivatives were isolated from the insect Cyclopelta parva. Racemic 1–3 were further separated by chir...

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Autores principales: Chen, Heng, Yan, Yong-Ming, Wang, Dai-Wei, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229431/
https://www.ncbi.nlm.nih.gov/pubmed/34207872
http://dx.doi.org/10.3390/molecules26123531
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author Chen, Heng
Yan, Yong-Ming
Wang, Dai-Wei
Cheng, Yong-Xian
author_facet Chen, Heng
Yan, Yong-Ming
Wang, Dai-Wei
Cheng, Yong-Xian
author_sort Chen, Heng
collection PubMed
description Five new compounds including three pairs of enantiomeric xanthine analogues, parvaxanthines D–F (1–3), two new guanosine derivatives, asponguanosines C and D (6 and 7), along with two known adenine derivatives were isolated from the insect Cyclopelta parva. Racemic 1–3 were further separated by chiral HPLC. Their absolute configurations were assigned by spectroscopic and computational methods. It is interesting that all of these isolates are natural product hybrids. Antiviral, immunosuppressive, antitumor and anti-inflammatory properties of all the isolates were evaluated.
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spelling pubmed-82294312021-06-26 Parvaxanthines D–F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva Chen, Heng Yan, Yong-Ming Wang, Dai-Wei Cheng, Yong-Xian Molecules Article Five new compounds including three pairs of enantiomeric xanthine analogues, parvaxanthines D–F (1–3), two new guanosine derivatives, asponguanosines C and D (6 and 7), along with two known adenine derivatives were isolated from the insect Cyclopelta parva. Racemic 1–3 were further separated by chiral HPLC. Their absolute configurations were assigned by spectroscopic and computational methods. It is interesting that all of these isolates are natural product hybrids. Antiviral, immunosuppressive, antitumor and anti-inflammatory properties of all the isolates were evaluated. MDPI 2021-06-09 /pmc/articles/PMC8229431/ /pubmed/34207872 http://dx.doi.org/10.3390/molecules26123531 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Heng
Yan, Yong-Ming
Wang, Dai-Wei
Cheng, Yong-Xian
Parvaxanthines D–F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva
title Parvaxanthines D–F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva
title_full Parvaxanthines D–F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva
title_fullStr Parvaxanthines D–F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva
title_full_unstemmed Parvaxanthines D–F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva
title_short Parvaxanthines D–F and Asponguanosines C and D, Racemic Natural Hybrids from the Insect Cyclopelta parva
title_sort parvaxanthines d–f and asponguanosines c and d, racemic natural hybrids from the insect cyclopelta parva
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229431/
https://www.ncbi.nlm.nih.gov/pubmed/34207872
http://dx.doi.org/10.3390/molecules26123531
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