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A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological ta...

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Autores principales: Domi, Elisa, Hoxha, Malvina, Prendi, Emanuela, Zappacosta, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229470/
https://www.ncbi.nlm.nih.gov/pubmed/34205021
http://dx.doi.org/10.3390/cells10061380
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author Domi, Elisa
Hoxha, Malvina
Prendi, Emanuela
Zappacosta, Bruno
author_facet Domi, Elisa
Hoxha, Malvina
Prendi, Emanuela
Zappacosta, Bruno
author_sort Domi, Elisa
collection PubMed
description Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological targets. Sirtuin1 (SIRT1) seems to be a potential target for DMD. In muscle tissue, SIRT1 exerts anti-inflammatory and antioxidant effects. The aim of this study is to summarize all the findings of in vivo and in vitro literature studies about the potential role of SIRT1 in DMD. A systematic literature search was performed according to PRISMA guidelines. Twenty-three articles satisfied the eligibility criteria. It emerged that SIRT1 inhibition led to muscle fragility, while conversely its activation improved muscle function. Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting.
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spelling pubmed-82294702021-06-26 A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy Domi, Elisa Hoxha, Malvina Prendi, Emanuela Zappacosta, Bruno Cells Systematic Review Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological targets. Sirtuin1 (SIRT1) seems to be a potential target for DMD. In muscle tissue, SIRT1 exerts anti-inflammatory and antioxidant effects. The aim of this study is to summarize all the findings of in vivo and in vitro literature studies about the potential role of SIRT1 in DMD. A systematic literature search was performed according to PRISMA guidelines. Twenty-three articles satisfied the eligibility criteria. It emerged that SIRT1 inhibition led to muscle fragility, while conversely its activation improved muscle function. Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting. MDPI 2021-06-03 /pmc/articles/PMC8229470/ /pubmed/34205021 http://dx.doi.org/10.3390/cells10061380 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Domi, Elisa
Hoxha, Malvina
Prendi, Emanuela
Zappacosta, Bruno
A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
title A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
title_full A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
title_fullStr A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
title_full_unstemmed A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
title_short A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
title_sort systematic review on the role of sirt1 in duchenne muscular dystrophy
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229470/
https://www.ncbi.nlm.nih.gov/pubmed/34205021
http://dx.doi.org/10.3390/cells10061380
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