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Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment
Ischemic stroke (IS) is still among the leading causes of death and disability worldwide. The pathogenic mechanisms beyond its development are several and are complex and this is the main reason why a functional therapy is still missed. The beneficial effects of natural compounds against cardiovascu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229516/ https://www.ncbi.nlm.nih.gov/pubmed/34201106 http://dx.doi.org/10.3390/nu13061967 |
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author | Pacifici, Francesca Rovella, Valentina Pastore, Donatella Bellia, Alfonso Abete, Pasquale Donadel, Giulia Santini, Silvia Beck, Heinz Ricordi, Camillo Daniele, Nicola Di Lauro, Davide Della-Morte, David |
author_facet | Pacifici, Francesca Rovella, Valentina Pastore, Donatella Bellia, Alfonso Abete, Pasquale Donadel, Giulia Santini, Silvia Beck, Heinz Ricordi, Camillo Daniele, Nicola Di Lauro, Davide Della-Morte, David |
author_sort | Pacifici, Francesca |
collection | PubMed |
description | Ischemic stroke (IS) is still among the leading causes of death and disability worldwide. The pathogenic mechanisms beyond its development are several and are complex and this is the main reason why a functional therapy is still missed. The beneficial effects of natural compounds against cardiovascular diseases and IS have been investigated for a long time. In this article, we reviewed the association between the most studied polyphenols and stroke protection in terms of prevention, effect on acute phase, and rehabilitation. We described experimental and epidemiological studies reporting the role of flavonols, phenolic acid, and stilbens on ischemic mechanisms leading to stroke. We analyzed the principal animal models used to evaluate the impact of these micronutrients to cerebral blood flow and to molecular pathways involved in oxidative stress and inflammation modulation, such as sirtuins. We reported the most significant clinical trials demonstrated as the persistent use of polyphenols is clinically relevant in terms of the reduction of vascular risk factors for IS, such as Atrial Fibrillation. Interestingly, different kinds of polyphenols provide brain protection by activating different pathways and mechanisms, like inducing antithrombotic effect, such as Honokiol. For this reason, we discussed an appropriate integrative use of them as a possible therapeutic alternative against stroke. |
format | Online Article Text |
id | pubmed-8229516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82295162021-06-26 Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment Pacifici, Francesca Rovella, Valentina Pastore, Donatella Bellia, Alfonso Abete, Pasquale Donadel, Giulia Santini, Silvia Beck, Heinz Ricordi, Camillo Daniele, Nicola Di Lauro, Davide Della-Morte, David Nutrients Review Ischemic stroke (IS) is still among the leading causes of death and disability worldwide. The pathogenic mechanisms beyond its development are several and are complex and this is the main reason why a functional therapy is still missed. The beneficial effects of natural compounds against cardiovascular diseases and IS have been investigated for a long time. In this article, we reviewed the association between the most studied polyphenols and stroke protection in terms of prevention, effect on acute phase, and rehabilitation. We described experimental and epidemiological studies reporting the role of flavonols, phenolic acid, and stilbens on ischemic mechanisms leading to stroke. We analyzed the principal animal models used to evaluate the impact of these micronutrients to cerebral blood flow and to molecular pathways involved in oxidative stress and inflammation modulation, such as sirtuins. We reported the most significant clinical trials demonstrated as the persistent use of polyphenols is clinically relevant in terms of the reduction of vascular risk factors for IS, such as Atrial Fibrillation. Interestingly, different kinds of polyphenols provide brain protection by activating different pathways and mechanisms, like inducing antithrombotic effect, such as Honokiol. For this reason, we discussed an appropriate integrative use of them as a possible therapeutic alternative against stroke. MDPI 2021-06-08 /pmc/articles/PMC8229516/ /pubmed/34201106 http://dx.doi.org/10.3390/nu13061967 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pacifici, Francesca Rovella, Valentina Pastore, Donatella Bellia, Alfonso Abete, Pasquale Donadel, Giulia Santini, Silvia Beck, Heinz Ricordi, Camillo Daniele, Nicola Di Lauro, Davide Della-Morte, David Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment |
title | Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment |
title_full | Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment |
title_fullStr | Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment |
title_full_unstemmed | Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment |
title_short | Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment |
title_sort | polyphenols and ischemic stroke: insight into one of the best strategies for prevention and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229516/ https://www.ncbi.nlm.nih.gov/pubmed/34201106 http://dx.doi.org/10.3390/nu13061967 |
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