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Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose

The potential of bacterial cellulose as a carrier for the transport of ibuprofen (a typical example of non-steroidal anti-inflammatory drugs) through the skin was investigated. Ibuprofen and its amino acid ester salts-loaded BC membranes were prepared through a simple methodology and characterized i...

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Autores principales: Ossowicz-Rupniewska, Paula, Rakoczy, Rafał, Nowak, Anna, Konopacki, Maciej, Klebeko, Joanna, Świątek, Ewelina, Janus, Ewa, Duchnik, Wiktoria, Wenelska, Karolina, Kucharski, Łukasz, Klimowicz, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229522/
https://www.ncbi.nlm.nih.gov/pubmed/34200719
http://dx.doi.org/10.3390/ijms22126252
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author Ossowicz-Rupniewska, Paula
Rakoczy, Rafał
Nowak, Anna
Konopacki, Maciej
Klebeko, Joanna
Świątek, Ewelina
Janus, Ewa
Duchnik, Wiktoria
Wenelska, Karolina
Kucharski, Łukasz
Klimowicz, Adam
author_facet Ossowicz-Rupniewska, Paula
Rakoczy, Rafał
Nowak, Anna
Konopacki, Maciej
Klebeko, Joanna
Świątek, Ewelina
Janus, Ewa
Duchnik, Wiktoria
Wenelska, Karolina
Kucharski, Łukasz
Klimowicz, Adam
author_sort Ossowicz-Rupniewska, Paula
collection PubMed
description The potential of bacterial cellulose as a carrier for the transport of ibuprofen (a typical example of non-steroidal anti-inflammatory drugs) through the skin was investigated. Ibuprofen and its amino acid ester salts-loaded BC membranes were prepared through a simple methodology and characterized in terms of structure and morphology. Two salts of amino acid isopropyl esters were used in the research, namely L-valine isopropyl ester ibuprofenate ([ValOiPr][IBU]) and L-leucine isopropyl ester ibuprofenate ([LeuOiPr][IBU]). [LeuOiPr][IBU] is a new compound; therefore, it has been fully characterized and its identity confirmed. For all membranes obtained the surface morphology, tensile mechanical properties, active compound dissolution assays, and permeation and skin accumulation studies of API (active pharmaceutical ingredient) were determined. The obtained membranes were very homogeneous. In vitro diffusion studies with Franz cells were conducted using pig epidermal membranes, and showed that the incorporation of ibuprofen in BC membranes provided lower permeation rates to those obtained with amino acids ester salts of ibuprofen. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes indicates the enormous potentialities of using BC membranes for transdermal application of ibuprofen in the form of amino acid ester salts.
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spelling pubmed-82295222021-06-26 Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose Ossowicz-Rupniewska, Paula Rakoczy, Rafał Nowak, Anna Konopacki, Maciej Klebeko, Joanna Świątek, Ewelina Janus, Ewa Duchnik, Wiktoria Wenelska, Karolina Kucharski, Łukasz Klimowicz, Adam Int J Mol Sci Article The potential of bacterial cellulose as a carrier for the transport of ibuprofen (a typical example of non-steroidal anti-inflammatory drugs) through the skin was investigated. Ibuprofen and its amino acid ester salts-loaded BC membranes were prepared through a simple methodology and characterized in terms of structure and morphology. Two salts of amino acid isopropyl esters were used in the research, namely L-valine isopropyl ester ibuprofenate ([ValOiPr][IBU]) and L-leucine isopropyl ester ibuprofenate ([LeuOiPr][IBU]). [LeuOiPr][IBU] is a new compound; therefore, it has been fully characterized and its identity confirmed. For all membranes obtained the surface morphology, tensile mechanical properties, active compound dissolution assays, and permeation and skin accumulation studies of API (active pharmaceutical ingredient) were determined. The obtained membranes were very homogeneous. In vitro diffusion studies with Franz cells were conducted using pig epidermal membranes, and showed that the incorporation of ibuprofen in BC membranes provided lower permeation rates to those obtained with amino acids ester salts of ibuprofen. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes indicates the enormous potentialities of using BC membranes for transdermal application of ibuprofen in the form of amino acid ester salts. MDPI 2021-06-10 /pmc/articles/PMC8229522/ /pubmed/34200719 http://dx.doi.org/10.3390/ijms22126252 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ossowicz-Rupniewska, Paula
Rakoczy, Rafał
Nowak, Anna
Konopacki, Maciej
Klebeko, Joanna
Świątek, Ewelina
Janus, Ewa
Duchnik, Wiktoria
Wenelska, Karolina
Kucharski, Łukasz
Klimowicz, Adam
Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose
title Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose
title_full Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose
title_fullStr Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose
title_full_unstemmed Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose
title_short Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose
title_sort transdermal delivery systems for ibuprofen and ibuprofen modified with amino acids alkyl esters based on bacterial cellulose
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229522/
https://www.ncbi.nlm.nih.gov/pubmed/34200719
http://dx.doi.org/10.3390/ijms22126252
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