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NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications

Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expre...

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Autores principales: Siemaszko, Jagoda, Marzec-Przyszlak, Aleksandra, Bogunia-Kubik, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229527/
https://www.ncbi.nlm.nih.gov/pubmed/34200375
http://dx.doi.org/10.3390/cells10061420
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author Siemaszko, Jagoda
Marzec-Przyszlak, Aleksandra
Bogunia-Kubik, Katarzyna
author_facet Siemaszko, Jagoda
Marzec-Przyszlak, Aleksandra
Bogunia-Kubik, Katarzyna
author_sort Siemaszko, Jagoda
collection PubMed
description Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expression and activation of those receptors is fundamental for the proper functionality of NK cells. One of the best known activating receptors is NKG2D, a member of the CD94/NKG2 family. Due to a specific NKG2D binding with its eight different ligands, which are overexpressed in transformed, infected and stressed cells, NK cells are able to recognize and attack their targets. The NKG2D receptor has an enormous significance in various, autoimmune diseases, viral and bacterial infections as well as for transplantation outcomes and complications. This review focuses on the NKG2D receptor, the mechanism of its action, clinical relevance of its gene polymorphisms and a potential application in various clinical settings.
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spelling pubmed-82295272021-06-26 NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications Siemaszko, Jagoda Marzec-Przyszlak, Aleksandra Bogunia-Kubik, Katarzyna Cells Review Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expression and activation of those receptors is fundamental for the proper functionality of NK cells. One of the best known activating receptors is NKG2D, a member of the CD94/NKG2 family. Due to a specific NKG2D binding with its eight different ligands, which are overexpressed in transformed, infected and stressed cells, NK cells are able to recognize and attack their targets. The NKG2D receptor has an enormous significance in various, autoimmune diseases, viral and bacterial infections as well as for transplantation outcomes and complications. This review focuses on the NKG2D receptor, the mechanism of its action, clinical relevance of its gene polymorphisms and a potential application in various clinical settings. MDPI 2021-06-07 /pmc/articles/PMC8229527/ /pubmed/34200375 http://dx.doi.org/10.3390/cells10061420 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Siemaszko, Jagoda
Marzec-Przyszlak, Aleksandra
Bogunia-Kubik, Katarzyna
NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
title NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
title_full NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
title_fullStr NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
title_full_unstemmed NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
title_short NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
title_sort nkg2d natural killer cell receptor—a short description and potential clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229527/
https://www.ncbi.nlm.nih.gov/pubmed/34200375
http://dx.doi.org/10.3390/cells10061420
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