Cargando…
NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications
Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expre...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229527/ https://www.ncbi.nlm.nih.gov/pubmed/34200375 http://dx.doi.org/10.3390/cells10061420 |
_version_ | 1783712997636571136 |
---|---|
author | Siemaszko, Jagoda Marzec-Przyszlak, Aleksandra Bogunia-Kubik, Katarzyna |
author_facet | Siemaszko, Jagoda Marzec-Przyszlak, Aleksandra Bogunia-Kubik, Katarzyna |
author_sort | Siemaszko, Jagoda |
collection | PubMed |
description | Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expression and activation of those receptors is fundamental for the proper functionality of NK cells. One of the best known activating receptors is NKG2D, a member of the CD94/NKG2 family. Due to a specific NKG2D binding with its eight different ligands, which are overexpressed in transformed, infected and stressed cells, NK cells are able to recognize and attack their targets. The NKG2D receptor has an enormous significance in various, autoimmune diseases, viral and bacterial infections as well as for transplantation outcomes and complications. This review focuses on the NKG2D receptor, the mechanism of its action, clinical relevance of its gene polymorphisms and a potential application in various clinical settings. |
format | Online Article Text |
id | pubmed-8229527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82295272021-06-26 NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications Siemaszko, Jagoda Marzec-Przyszlak, Aleksandra Bogunia-Kubik, Katarzyna Cells Review Natural Killer (NK) cells are natural cytotoxic, effector cells of the innate immune system. They can recognize transformed or infected cells. NK cells are armed with a set of activating and inhibitory receptors which are able to bind to their ligands on target cells. The right balance between expression and activation of those receptors is fundamental for the proper functionality of NK cells. One of the best known activating receptors is NKG2D, a member of the CD94/NKG2 family. Due to a specific NKG2D binding with its eight different ligands, which are overexpressed in transformed, infected and stressed cells, NK cells are able to recognize and attack their targets. The NKG2D receptor has an enormous significance in various, autoimmune diseases, viral and bacterial infections as well as for transplantation outcomes and complications. This review focuses on the NKG2D receptor, the mechanism of its action, clinical relevance of its gene polymorphisms and a potential application in various clinical settings. MDPI 2021-06-07 /pmc/articles/PMC8229527/ /pubmed/34200375 http://dx.doi.org/10.3390/cells10061420 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Siemaszko, Jagoda Marzec-Przyszlak, Aleksandra Bogunia-Kubik, Katarzyna NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications |
title | NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications |
title_full | NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications |
title_fullStr | NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications |
title_full_unstemmed | NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications |
title_short | NKG2D Natural Killer Cell Receptor—A Short Description and Potential Clinical Applications |
title_sort | nkg2d natural killer cell receptor—a short description and potential clinical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229527/ https://www.ncbi.nlm.nih.gov/pubmed/34200375 http://dx.doi.org/10.3390/cells10061420 |
work_keys_str_mv | AT siemaszkojagoda nkg2dnaturalkillercellreceptorashortdescriptionandpotentialclinicalapplications AT marzecprzyszlakaleksandra nkg2dnaturalkillercellreceptorashortdescriptionandpotentialclinicalapplications AT boguniakubikkatarzyna nkg2dnaturalkillercellreceptorashortdescriptionandpotentialclinicalapplications |