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Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study

A randomized, double-blind, placebo-controlled study was conducted with the primary objective of assessing the effect of a natural extract of Sclerocarya birrea on glucose metabolism in subjects with prediabetes. The duration of the study was 90 days. Thirty-three subjects assigned to the experiment...

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Autores principales: Victoria-Montesinos, Desirée, Sánchez-Macarro, Maravillas, Gabaldón-Hernández, José Antonio, Abellán-Ruiz, María Salud, Querol-Calderón, María, Luque-Rubia, Antonio J., Bernal-Morell, Enrique, Ávila-Gandía, Vicente, López-Román, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229573/
https://www.ncbi.nlm.nih.gov/pubmed/34204042
http://dx.doi.org/10.3390/nu13061948
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author Victoria-Montesinos, Desirée
Sánchez-Macarro, Maravillas
Gabaldón-Hernández, José Antonio
Abellán-Ruiz, María Salud
Querol-Calderón, María
Luque-Rubia, Antonio J.
Bernal-Morell, Enrique
Ávila-Gandía, Vicente
López-Román, Francisco Javier
author_facet Victoria-Montesinos, Desirée
Sánchez-Macarro, Maravillas
Gabaldón-Hernández, José Antonio
Abellán-Ruiz, María Salud
Querol-Calderón, María
Luque-Rubia, Antonio J.
Bernal-Morell, Enrique
Ávila-Gandía, Vicente
López-Román, Francisco Javier
author_sort Victoria-Montesinos, Desirée
collection PubMed
description A randomized, double-blind, placebo-controlled study was conducted with the primary objective of assessing the effect of a natural extract of Sclerocarya birrea on glucose metabolism in subjects with prediabetes. The duration of the study was 90 days. Thirty-three subjects assigned to the experimental group (daily ingestion of 100 mg of the nutraceutical product) and 34 assigned to the placebo group completed the study. There were 36 men and 31 women with a mean age of 32.3 ± 14.1 years. In the area under the curve (AUC) of the oral glucose tolerance test (OGTT), statistically significant decreases in the experimental group at 40 and 90 days as compared with baseline were found, whereas significant changes in the placebo group were not observed. Within-group differences were statistically significant in favor of the experimental group for glucose peak at OGTT, serum insulin, insulin resistance markers, and flow-mediated dilation. Changes in lipid and anthropometric parameters were not observed, although there was a trend for lower cholesterol levels and a decrease in body weight in the experimental group. Decreases in systolic blood pressure were also higher among subjects in the experimental group. This exploratory study confirms the antidiabetic activity of Sclerocarya birrea in prediabetes. Further studies using better measurements of beta-cell function are needed to clarify the underlying mechanisms of the hypoglycemic effect of this natural compound.
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spelling pubmed-82295732021-06-26 Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study Victoria-Montesinos, Desirée Sánchez-Macarro, Maravillas Gabaldón-Hernández, José Antonio Abellán-Ruiz, María Salud Querol-Calderón, María Luque-Rubia, Antonio J. Bernal-Morell, Enrique Ávila-Gandía, Vicente López-Román, Francisco Javier Nutrients Article A randomized, double-blind, placebo-controlled study was conducted with the primary objective of assessing the effect of a natural extract of Sclerocarya birrea on glucose metabolism in subjects with prediabetes. The duration of the study was 90 days. Thirty-three subjects assigned to the experimental group (daily ingestion of 100 mg of the nutraceutical product) and 34 assigned to the placebo group completed the study. There were 36 men and 31 women with a mean age of 32.3 ± 14.1 years. In the area under the curve (AUC) of the oral glucose tolerance test (OGTT), statistically significant decreases in the experimental group at 40 and 90 days as compared with baseline were found, whereas significant changes in the placebo group were not observed. Within-group differences were statistically significant in favor of the experimental group for glucose peak at OGTT, serum insulin, insulin resistance markers, and flow-mediated dilation. Changes in lipid and anthropometric parameters were not observed, although there was a trend for lower cholesterol levels and a decrease in body weight in the experimental group. Decreases in systolic blood pressure were also higher among subjects in the experimental group. This exploratory study confirms the antidiabetic activity of Sclerocarya birrea in prediabetes. Further studies using better measurements of beta-cell function are needed to clarify the underlying mechanisms of the hypoglycemic effect of this natural compound. MDPI 2021-06-06 /pmc/articles/PMC8229573/ /pubmed/34204042 http://dx.doi.org/10.3390/nu13061948 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Victoria-Montesinos, Desirée
Sánchez-Macarro, Maravillas
Gabaldón-Hernández, José Antonio
Abellán-Ruiz, María Salud
Querol-Calderón, María
Luque-Rubia, Antonio J.
Bernal-Morell, Enrique
Ávila-Gandía, Vicente
López-Román, Francisco Javier
Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study
title Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study
title_full Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study
title_fullStr Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study
title_full_unstemmed Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study
title_short Effect of Dietary Supplementation with a Natural Extract of Sclerocarya birrea on Glycemic Metabolism in Subjects with Prediabetes: A Randomized Double-Blind Placebo-Controlled Study
title_sort effect of dietary supplementation with a natural extract of sclerocarya birrea on glycemic metabolism in subjects with prediabetes: a randomized double-blind placebo-controlled study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229573/
https://www.ncbi.nlm.nih.gov/pubmed/34204042
http://dx.doi.org/10.3390/nu13061948
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