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Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response

Nano-scale surface roughening of metallic bio-implants plays an important role in the clinical success of hard tissue reconstruction and replacement. In this study, the nano-topographical features of titanium-niobium-zirconium (TNZ) alloy surfaces were controlled by using the target-ion induced plas...

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Autores principales: Lee, Min-Kyu, Lee, Hyun, Kim, Hyoun-Ee, Lee, Eun-Jung, Jang, Tae-Sik, Jung, Hyun-Do
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229642/
https://www.ncbi.nlm.nih.gov/pubmed/34200329
http://dx.doi.org/10.3390/nano11061507
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author Lee, Min-Kyu
Lee, Hyun
Kim, Hyoun-Ee
Lee, Eun-Jung
Jang, Tae-Sik
Jung, Hyun-Do
author_facet Lee, Min-Kyu
Lee, Hyun
Kim, Hyoun-Ee
Lee, Eun-Jung
Jang, Tae-Sik
Jung, Hyun-Do
author_sort Lee, Min-Kyu
collection PubMed
description Nano-scale surface roughening of metallic bio-implants plays an important role in the clinical success of hard tissue reconstruction and replacement. In this study, the nano-topographical features of titanium-niobium-zirconium (TNZ) alloy surfaces were controlled by using the target-ion induced plasma sputtering (TIPS) technique to improve the in vitro osteoblastic response. The TIPS technique is a novel strategy for etching the surface of metallic bio-implants using bombardment of target metal cations, which were accelerated by an extremely high negative bias voltage applied to the substrates. The nano-topography of the TNZ surfaces was successfully controlled by modulating experimental variables (such as the ion etching energy and the type of substrate or target materials) of TIPS. As a result, various nanopatterns (size: 10–210 nm) were fabricated on the surface of the TNZ alloys. Compared with the control group, experimental groups with nanopattern widths of ≥130 nm (130 and 210 nm groups) exhibited superior cell adhesion, proliferation, and differentiation. Our findings demonstrate that TIPS is a promising technology that can impart excellent biological functions to the surface of metallic bio-implants.
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spelling pubmed-82296422021-06-26 Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response Lee, Min-Kyu Lee, Hyun Kim, Hyoun-Ee Lee, Eun-Jung Jang, Tae-Sik Jung, Hyun-Do Nanomaterials (Basel) Communication Nano-scale surface roughening of metallic bio-implants plays an important role in the clinical success of hard tissue reconstruction and replacement. In this study, the nano-topographical features of titanium-niobium-zirconium (TNZ) alloy surfaces were controlled by using the target-ion induced plasma sputtering (TIPS) technique to improve the in vitro osteoblastic response. The TIPS technique is a novel strategy for etching the surface of metallic bio-implants using bombardment of target metal cations, which were accelerated by an extremely high negative bias voltage applied to the substrates. The nano-topography of the TNZ surfaces was successfully controlled by modulating experimental variables (such as the ion etching energy and the type of substrate or target materials) of TIPS. As a result, various nanopatterns (size: 10–210 nm) were fabricated on the surface of the TNZ alloys. Compared with the control group, experimental groups with nanopattern widths of ≥130 nm (130 and 210 nm groups) exhibited superior cell adhesion, proliferation, and differentiation. Our findings demonstrate that TIPS is a promising technology that can impart excellent biological functions to the surface of metallic bio-implants. MDPI 2021-06-07 /pmc/articles/PMC8229642/ /pubmed/34200329 http://dx.doi.org/10.3390/nano11061507 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Lee, Min-Kyu
Lee, Hyun
Kim, Hyoun-Ee
Lee, Eun-Jung
Jang, Tae-Sik
Jung, Hyun-Do
Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response
title Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response
title_full Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response
title_fullStr Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response
title_full_unstemmed Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response
title_short Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response
title_sort nano-topographical control of ti-nb-zr alloy surfaces for enhanced osteoblastic response
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229642/
https://www.ncbi.nlm.nih.gov/pubmed/34200329
http://dx.doi.org/10.3390/nano11061507
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