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Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population
Human astroviruses are an important cause of viral gastroenteritis globally, yet few studies have investigated the serostatus of adults to establish rates of previous infection. Here, we applied biolayer interferometry immunosorbent assay (BLI-ISA), a recently developed serosurveillance technique, t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229645/ https://www.ncbi.nlm.nih.gov/pubmed/34070419 http://dx.doi.org/10.3390/v13060979 |
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author | Meyer, Lena Delgado-Cunningham, Kevin Lorig-Roach, Nicholas Ford, Jordan DuBois, Rebecca M. |
author_facet | Meyer, Lena Delgado-Cunningham, Kevin Lorig-Roach, Nicholas Ford, Jordan DuBois, Rebecca M. |
author_sort | Meyer, Lena |
collection | PubMed |
description | Human astroviruses are an important cause of viral gastroenteritis globally, yet few studies have investigated the serostatus of adults to establish rates of previous infection. Here, we applied biolayer interferometry immunosorbent assay (BLI-ISA), a recently developed serosurveillance technique, to measure the presence of blood plasma IgG antibodies directed towards the human astrovirus capsid spikes from serotypes 1–8 in a cross-sectional sample of a United States adult population. The seroprevalence rates of IgG antibodies were 73% for human astrovirus serotype 1, 62% for serotype 3, 52% for serotype 4, 29% for serotype 5, 27% for serotype 8, 22% for serotype 2, 8% for serotype 6, and 8% for serotype 7. Notably, seroprevalence rates for capsid spike antigens correlate with neutralizing antibody rates determined previously. This work is the first seroprevalence study evaluating all eight classical human astrovirus serotypes. |
format | Online Article Text |
id | pubmed-8229645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82296452021-06-26 Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population Meyer, Lena Delgado-Cunningham, Kevin Lorig-Roach, Nicholas Ford, Jordan DuBois, Rebecca M. Viruses Article Human astroviruses are an important cause of viral gastroenteritis globally, yet few studies have investigated the serostatus of adults to establish rates of previous infection. Here, we applied biolayer interferometry immunosorbent assay (BLI-ISA), a recently developed serosurveillance technique, to measure the presence of blood plasma IgG antibodies directed towards the human astrovirus capsid spikes from serotypes 1–8 in a cross-sectional sample of a United States adult population. The seroprevalence rates of IgG antibodies were 73% for human astrovirus serotype 1, 62% for serotype 3, 52% for serotype 4, 29% for serotype 5, 27% for serotype 8, 22% for serotype 2, 8% for serotype 6, and 8% for serotype 7. Notably, seroprevalence rates for capsid spike antigens correlate with neutralizing antibody rates determined previously. This work is the first seroprevalence study evaluating all eight classical human astrovirus serotypes. MDPI 2021-05-25 /pmc/articles/PMC8229645/ /pubmed/34070419 http://dx.doi.org/10.3390/v13060979 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Meyer, Lena Delgado-Cunningham, Kevin Lorig-Roach, Nicholas Ford, Jordan DuBois, Rebecca M. Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population |
title | Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population |
title_full | Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population |
title_fullStr | Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population |
title_full_unstemmed | Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population |
title_short | Human Astrovirus 1–8 Seroprevalence Evaluation in a United States Adult Population |
title_sort | human astrovirus 1–8 seroprevalence evaluation in a united states adult population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229645/ https://www.ncbi.nlm.nih.gov/pubmed/34070419 http://dx.doi.org/10.3390/v13060979 |
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