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Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain
As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different the...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229751/ https://www.ncbi.nlm.nih.gov/pubmed/34207764 http://dx.doi.org/10.3390/pathogens10060729 |
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author | Fonseca, Kátia da Silva Perin, Luísa de Paiva, Nívia Carolina Nogueira da Silva, Beatriz Cristiane Duarte, Thays Helena Chaves Marques, Flávia de Souza Costa, Guilherme de Paula Molina, Israel Correa-Oliveira, Rodrigo Vieira, Paula Melo de Abreu Carneiro, Cláudia Martins |
author_facet | Fonseca, Kátia da Silva Perin, Luísa de Paiva, Nívia Carolina Nogueira da Silva, Beatriz Cristiane Duarte, Thays Helena Chaves Marques, Flávia de Souza Costa, Guilherme de Paula Molina, Israel Correa-Oliveira, Rodrigo Vieira, Paula Melo de Abreu Carneiro, Cláudia Martins |
author_sort | Fonseca, Kátia da Silva |
collection | PubMed |
description | As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different therapeutic schemes with benznidazole (BNZ) on the acute and chronic phases of the disease, using mice infected with strains that have different BNZ susceptibilities. Our results show that the groups of animals infected by VL-10 strain, when treated in the chronic phase with a lower dose of BNZ for a longer period of time (40 mg/kg/day for 40 days) presented better treatment efficacy than with the standard protocol (100 mg/kg/day for 20 days) although the best result in the treatment of the animals infected by the VL-10 strain was with100 mg/kg/day for 40 days. In the acute infection by the Y and VL-10 strains of T. cruzi, the treatment with a standard dose, but with a longer time of treatment (100 mg/kg/day for 40 days) presented the best results. Given these data, our results indicate that for BNZ, the theory of dose and time proportionality does not apply to the phases of infection. |
format | Online Article Text |
id | pubmed-8229751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82297512021-06-26 Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain Fonseca, Kátia da Silva Perin, Luísa de Paiva, Nívia Carolina Nogueira da Silva, Beatriz Cristiane Duarte, Thays Helena Chaves Marques, Flávia de Souza Costa, Guilherme de Paula Molina, Israel Correa-Oliveira, Rodrigo Vieira, Paula Melo de Abreu Carneiro, Cláudia Martins Pathogens Article As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different therapeutic schemes with benznidazole (BNZ) on the acute and chronic phases of the disease, using mice infected with strains that have different BNZ susceptibilities. Our results show that the groups of animals infected by VL-10 strain, when treated in the chronic phase with a lower dose of BNZ for a longer period of time (40 mg/kg/day for 40 days) presented better treatment efficacy than with the standard protocol (100 mg/kg/day for 20 days) although the best result in the treatment of the animals infected by the VL-10 strain was with100 mg/kg/day for 40 days. In the acute infection by the Y and VL-10 strains of T. cruzi, the treatment with a standard dose, but with a longer time of treatment (100 mg/kg/day for 40 days) presented the best results. Given these data, our results indicate that for BNZ, the theory of dose and time proportionality does not apply to the phases of infection. MDPI 2021-06-09 /pmc/articles/PMC8229751/ /pubmed/34207764 http://dx.doi.org/10.3390/pathogens10060729 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fonseca, Kátia da Silva Perin, Luísa de Paiva, Nívia Carolina Nogueira da Silva, Beatriz Cristiane Duarte, Thays Helena Chaves Marques, Flávia de Souza Costa, Guilherme de Paula Molina, Israel Correa-Oliveira, Rodrigo Vieira, Paula Melo de Abreu Carneiro, Cláudia Martins Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain |
title | Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain |
title_full | Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain |
title_fullStr | Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain |
title_full_unstemmed | Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain |
title_short | Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain |
title_sort | benznidazole treatment: time- and dose-dependence varies with the trypanosoma cruzi strain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229751/ https://www.ncbi.nlm.nih.gov/pubmed/34207764 http://dx.doi.org/10.3390/pathogens10060729 |
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