Cargando…

Risk Factors for Mortality in Colombian Patients with Candidemia

The aim of the study was to describe the microbiology and susceptibility profile of candidemia and to identify the risk factors associated with mortality in Colombia. A cohort of patients was followed for 30 days during 2008 to 2010. Microbiological identification and susceptibility assessments were...

Descripción completa

Detalles Bibliográficos
Autores principales: Cortés, Jorge Alberto, Montañez, Anita María, Carreño-Gutiérrez, Ana María, Reyes, Patricia, Gómez, Carlos Hernando, Pescador, Angela, Ariza, Beatriz, Rosso, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229794/
https://www.ncbi.nlm.nih.gov/pubmed/34073125
http://dx.doi.org/10.3390/jof7060442
_version_ 1783713062506725376
author Cortés, Jorge Alberto
Montañez, Anita María
Carreño-Gutiérrez, Ana María
Reyes, Patricia
Gómez, Carlos Hernando
Pescador, Angela
Ariza, Beatriz
Rosso, Fernando
author_facet Cortés, Jorge Alberto
Montañez, Anita María
Carreño-Gutiérrez, Ana María
Reyes, Patricia
Gómez, Carlos Hernando
Pescador, Angela
Ariza, Beatriz
Rosso, Fernando
author_sort Cortés, Jorge Alberto
collection PubMed
description The aim of the study was to describe the microbiology and susceptibility profile of candidemia and to identify the risk factors associated with mortality in Colombia. A cohort of patients was followed for 30 days during 2008 to 2010. Microbiological identification and susceptibility assessments were performed in a reference centre. Demographic, clinical and treatment variables were evaluated for their associations with mortality. A parametric survival regression analysis was used to identify the risk factors associated with mortality. A total of 109 patients with candidemia in four hospitals in Colombia were identified, with a median age of 30 years old. C. parapsilosis was the most frequently identified microorganism (38.5%); the susceptibility of all isolates was high to fluconazole and anidulafungin, except for C. glabrata isolates. The overall mortality was 35.7%, and the risk factors associated with mortality included lack of antifungal treatment (HR 5.5, 95% CI 3.6–11.4), cancer (HR 3.9, 95% CI 2.3–8.0), diabetes (HR 2.5, 95% CI 1.03–6.4), and age (HR 1.13 per every 10 years, 95% CI 1.02–1.24). Catheter removal was associated with a low mortality rate (HR 0.06, 95% CI 0.00–0.49). Prompt antifungal treatment, better glycemic control and catheter removal should be prioritized in the management of candidemia.
format Online
Article
Text
id pubmed-8229794
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82297942021-06-26 Risk Factors for Mortality in Colombian Patients with Candidemia Cortés, Jorge Alberto Montañez, Anita María Carreño-Gutiérrez, Ana María Reyes, Patricia Gómez, Carlos Hernando Pescador, Angela Ariza, Beatriz Rosso, Fernando J Fungi (Basel) Article The aim of the study was to describe the microbiology and susceptibility profile of candidemia and to identify the risk factors associated with mortality in Colombia. A cohort of patients was followed for 30 days during 2008 to 2010. Microbiological identification and susceptibility assessments were performed in a reference centre. Demographic, clinical and treatment variables were evaluated for their associations with mortality. A parametric survival regression analysis was used to identify the risk factors associated with mortality. A total of 109 patients with candidemia in four hospitals in Colombia were identified, with a median age of 30 years old. C. parapsilosis was the most frequently identified microorganism (38.5%); the susceptibility of all isolates was high to fluconazole and anidulafungin, except for C. glabrata isolates. The overall mortality was 35.7%, and the risk factors associated with mortality included lack of antifungal treatment (HR 5.5, 95% CI 3.6–11.4), cancer (HR 3.9, 95% CI 2.3–8.0), diabetes (HR 2.5, 95% CI 1.03–6.4), and age (HR 1.13 per every 10 years, 95% CI 1.02–1.24). Catheter removal was associated with a low mortality rate (HR 0.06, 95% CI 0.00–0.49). Prompt antifungal treatment, better glycemic control and catheter removal should be prioritized in the management of candidemia. MDPI 2021-05-31 /pmc/articles/PMC8229794/ /pubmed/34073125 http://dx.doi.org/10.3390/jof7060442 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cortés, Jorge Alberto
Montañez, Anita María
Carreño-Gutiérrez, Ana María
Reyes, Patricia
Gómez, Carlos Hernando
Pescador, Angela
Ariza, Beatriz
Rosso, Fernando
Risk Factors for Mortality in Colombian Patients with Candidemia
title Risk Factors for Mortality in Colombian Patients with Candidemia
title_full Risk Factors for Mortality in Colombian Patients with Candidemia
title_fullStr Risk Factors for Mortality in Colombian Patients with Candidemia
title_full_unstemmed Risk Factors for Mortality in Colombian Patients with Candidemia
title_short Risk Factors for Mortality in Colombian Patients with Candidemia
title_sort risk factors for mortality in colombian patients with candidemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229794/
https://www.ncbi.nlm.nih.gov/pubmed/34073125
http://dx.doi.org/10.3390/jof7060442
work_keys_str_mv AT cortesjorgealberto riskfactorsformortalityincolombianpatientswithcandidemia
AT montanezanitamaria riskfactorsformortalityincolombianpatientswithcandidemia
AT carrenogutierrezanamaria riskfactorsformortalityincolombianpatientswithcandidemia
AT reyespatricia riskfactorsformortalityincolombianpatientswithcandidemia
AT gomezcarloshernando riskfactorsformortalityincolombianpatientswithcandidemia
AT pescadorangela riskfactorsformortalityincolombianpatientswithcandidemia
AT arizabeatriz riskfactorsformortalityincolombianpatientswithcandidemia
AT rossofernando riskfactorsformortalityincolombianpatientswithcandidemia