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Risk Factors for Mortality in Colombian Patients with Candidemia
The aim of the study was to describe the microbiology and susceptibility profile of candidemia and to identify the risk factors associated with mortality in Colombia. A cohort of patients was followed for 30 days during 2008 to 2010. Microbiological identification and susceptibility assessments were...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229794/ https://www.ncbi.nlm.nih.gov/pubmed/34073125 http://dx.doi.org/10.3390/jof7060442 |
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author | Cortés, Jorge Alberto Montañez, Anita María Carreño-Gutiérrez, Ana María Reyes, Patricia Gómez, Carlos Hernando Pescador, Angela Ariza, Beatriz Rosso, Fernando |
author_facet | Cortés, Jorge Alberto Montañez, Anita María Carreño-Gutiérrez, Ana María Reyes, Patricia Gómez, Carlos Hernando Pescador, Angela Ariza, Beatriz Rosso, Fernando |
author_sort | Cortés, Jorge Alberto |
collection | PubMed |
description | The aim of the study was to describe the microbiology and susceptibility profile of candidemia and to identify the risk factors associated with mortality in Colombia. A cohort of patients was followed for 30 days during 2008 to 2010. Microbiological identification and susceptibility assessments were performed in a reference centre. Demographic, clinical and treatment variables were evaluated for their associations with mortality. A parametric survival regression analysis was used to identify the risk factors associated with mortality. A total of 109 patients with candidemia in four hospitals in Colombia were identified, with a median age of 30 years old. C. parapsilosis was the most frequently identified microorganism (38.5%); the susceptibility of all isolates was high to fluconazole and anidulafungin, except for C. glabrata isolates. The overall mortality was 35.7%, and the risk factors associated with mortality included lack of antifungal treatment (HR 5.5, 95% CI 3.6–11.4), cancer (HR 3.9, 95% CI 2.3–8.0), diabetes (HR 2.5, 95% CI 1.03–6.4), and age (HR 1.13 per every 10 years, 95% CI 1.02–1.24). Catheter removal was associated with a low mortality rate (HR 0.06, 95% CI 0.00–0.49). Prompt antifungal treatment, better glycemic control and catheter removal should be prioritized in the management of candidemia. |
format | Online Article Text |
id | pubmed-8229794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82297942021-06-26 Risk Factors for Mortality in Colombian Patients with Candidemia Cortés, Jorge Alberto Montañez, Anita María Carreño-Gutiérrez, Ana María Reyes, Patricia Gómez, Carlos Hernando Pescador, Angela Ariza, Beatriz Rosso, Fernando J Fungi (Basel) Article The aim of the study was to describe the microbiology and susceptibility profile of candidemia and to identify the risk factors associated with mortality in Colombia. A cohort of patients was followed for 30 days during 2008 to 2010. Microbiological identification and susceptibility assessments were performed in a reference centre. Demographic, clinical and treatment variables were evaluated for their associations with mortality. A parametric survival regression analysis was used to identify the risk factors associated with mortality. A total of 109 patients with candidemia in four hospitals in Colombia were identified, with a median age of 30 years old. C. parapsilosis was the most frequently identified microorganism (38.5%); the susceptibility of all isolates was high to fluconazole and anidulafungin, except for C. glabrata isolates. The overall mortality was 35.7%, and the risk factors associated with mortality included lack of antifungal treatment (HR 5.5, 95% CI 3.6–11.4), cancer (HR 3.9, 95% CI 2.3–8.0), diabetes (HR 2.5, 95% CI 1.03–6.4), and age (HR 1.13 per every 10 years, 95% CI 1.02–1.24). Catheter removal was associated with a low mortality rate (HR 0.06, 95% CI 0.00–0.49). Prompt antifungal treatment, better glycemic control and catheter removal should be prioritized in the management of candidemia. MDPI 2021-05-31 /pmc/articles/PMC8229794/ /pubmed/34073125 http://dx.doi.org/10.3390/jof7060442 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cortés, Jorge Alberto Montañez, Anita María Carreño-Gutiérrez, Ana María Reyes, Patricia Gómez, Carlos Hernando Pescador, Angela Ariza, Beatriz Rosso, Fernando Risk Factors for Mortality in Colombian Patients with Candidemia |
title | Risk Factors for Mortality in Colombian Patients with Candidemia |
title_full | Risk Factors for Mortality in Colombian Patients with Candidemia |
title_fullStr | Risk Factors for Mortality in Colombian Patients with Candidemia |
title_full_unstemmed | Risk Factors for Mortality in Colombian Patients with Candidemia |
title_short | Risk Factors for Mortality in Colombian Patients with Candidemia |
title_sort | risk factors for mortality in colombian patients with candidemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229794/ https://www.ncbi.nlm.nih.gov/pubmed/34073125 http://dx.doi.org/10.3390/jof7060442 |
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