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MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty

Aim. This study was designed to evaluate the relationship between microRNAs (miRNAs), miR-126-3p and miR-223-3p, as new biomarkers of platelet activation, and predicting recurrent thrombotic events after acute myocardial infarction (AMI). Methods and Results. The analysis included 598 patients rando...

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Autores principales: Hromadka, Milan, Motovska, Zuzana, Hlinomaz, Ota, Kala, Petr, Tousek, Frantisek, Jarkovsky, Jiri, Beranova, Marketa, Jansky, Pavel, Svoboda, Michal, Krepelkova, Iveta, Rokyta, Richard, Widimsky, Petr, Karpisek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230013/
https://www.ncbi.nlm.nih.gov/pubmed/34199723
http://dx.doi.org/10.3390/jpm11060508
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author Hromadka, Milan
Motovska, Zuzana
Hlinomaz, Ota
Kala, Petr
Tousek, Frantisek
Jarkovsky, Jiri
Beranova, Marketa
Jansky, Pavel
Svoboda, Michal
Krepelkova, Iveta
Rokyta, Richard
Widimsky, Petr
Karpisek, Michal
author_facet Hromadka, Milan
Motovska, Zuzana
Hlinomaz, Ota
Kala, Petr
Tousek, Frantisek
Jarkovsky, Jiri
Beranova, Marketa
Jansky, Pavel
Svoboda, Michal
Krepelkova, Iveta
Rokyta, Richard
Widimsky, Petr
Karpisek, Michal
author_sort Hromadka, Milan
collection PubMed
description Aim. This study was designed to evaluate the relationship between microRNAs (miRNAs), miR-126-3p and miR-223-3p, as new biomarkers of platelet activation, and predicting recurrent thrombotic events after acute myocardial infarction (AMI). Methods and Results. The analysis included 598 patients randomized in the PRAGUE-18 study (ticagrelor vs. prasugrel in AMI). The measurements of miRNAs were performed by using a novel miRNA immunoassay method. The association of miRNAs with the occurrence of the ischemic endpoint (EP) (cardiovascular death, nonfatal MI, or stroke) and bleeding were analyzed. The miR-223-3p level was significantly related to an increased risk of occurrence of the ischemic EP within 30 days (odds ratio (OR) = 15.74, 95% confidence interval (CI): 2.07–119.93, p = 0.008) and one year (OR = 3.18, 95% CI: 1.40–7.19, p = 0.006), respectively. The miR-126-3p to miR-223-3p ratio was related to a decreased risk of occurrence of EP within 30 days (OR = 0.14, 95% CI: 0.03–0.61, p = 0.009) and one year (OR = 0.37, 95% CI: 0.17–0.82, p = 0.014), respectively. MiRNAs were identified as independent predictors of EP even after adjustment for confounding clinical predictors. Adding miR-223-3p and miR-126-3p to miR-223-3p ratios as predictors into the model calculating the ischemic risk significantly increased the predictive accuracy for combined ischemic EP within one year more than using only clinical ischemic risk parameters. No associations between miRNAs and bleeding complications were identified. Conclusion. The miR-223-3p and the miR-126-3p are promising independent predictors of thrombotic events and can be used for ischemic risk stratification after AMI.
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spelling pubmed-82300132021-06-26 MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty Hromadka, Milan Motovska, Zuzana Hlinomaz, Ota Kala, Petr Tousek, Frantisek Jarkovsky, Jiri Beranova, Marketa Jansky, Pavel Svoboda, Michal Krepelkova, Iveta Rokyta, Richard Widimsky, Petr Karpisek, Michal J Pers Med Article Aim. This study was designed to evaluate the relationship between microRNAs (miRNAs), miR-126-3p and miR-223-3p, as new biomarkers of platelet activation, and predicting recurrent thrombotic events after acute myocardial infarction (AMI). Methods and Results. The analysis included 598 patients randomized in the PRAGUE-18 study (ticagrelor vs. prasugrel in AMI). The measurements of miRNAs were performed by using a novel miRNA immunoassay method. The association of miRNAs with the occurrence of the ischemic endpoint (EP) (cardiovascular death, nonfatal MI, or stroke) and bleeding were analyzed. The miR-223-3p level was significantly related to an increased risk of occurrence of the ischemic EP within 30 days (odds ratio (OR) = 15.74, 95% confidence interval (CI): 2.07–119.93, p = 0.008) and one year (OR = 3.18, 95% CI: 1.40–7.19, p = 0.006), respectively. The miR-126-3p to miR-223-3p ratio was related to a decreased risk of occurrence of EP within 30 days (OR = 0.14, 95% CI: 0.03–0.61, p = 0.009) and one year (OR = 0.37, 95% CI: 0.17–0.82, p = 0.014), respectively. MiRNAs were identified as independent predictors of EP even after adjustment for confounding clinical predictors. Adding miR-223-3p and miR-126-3p to miR-223-3p ratios as predictors into the model calculating the ischemic risk significantly increased the predictive accuracy for combined ischemic EP within one year more than using only clinical ischemic risk parameters. No associations between miRNAs and bleeding complications were identified. Conclusion. The miR-223-3p and the miR-126-3p are promising independent predictors of thrombotic events and can be used for ischemic risk stratification after AMI. MDPI 2021-06-04 /pmc/articles/PMC8230013/ /pubmed/34199723 http://dx.doi.org/10.3390/jpm11060508 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hromadka, Milan
Motovska, Zuzana
Hlinomaz, Ota
Kala, Petr
Tousek, Frantisek
Jarkovsky, Jiri
Beranova, Marketa
Jansky, Pavel
Svoboda, Michal
Krepelkova, Iveta
Rokyta, Richard
Widimsky, Petr
Karpisek, Michal
MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty
title MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty
title_full MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty
title_fullStr MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty
title_full_unstemmed MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty
title_short MiR-126-3p and MiR-223-3p as Biomarkers for Prediction of Thrombotic Risk in Patients with Acute Myocardial Infarction and Primary Angioplasty
title_sort mir-126-3p and mir-223-3p as biomarkers for prediction of thrombotic risk in patients with acute myocardial infarction and primary angioplasty
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230013/
https://www.ncbi.nlm.nih.gov/pubmed/34199723
http://dx.doi.org/10.3390/jpm11060508
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