Cargando…

Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables

Feline panleukopenia is a severe disease of cats caused by feline parvovirus (FPV), and marginally canine parvovirus (CPV). Despite being less rapid than CPV, FPV evolution deserves attention, especially since outbreaks of particular severity are currently reported. This apparently different virulen...

Descripción completa

Detalles Bibliográficos
Autores principales: Tucciarone, Claudia Maria, Franzo, Giovanni, Legnardi, Matteo, Lazzaro, Elena, Zoia, Andrea, Petini, Matteo, Furlanello, Tommaso, Caldin, Marco, Cecchinato, Mattia, Drigo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230023/
https://www.ncbi.nlm.nih.gov/pubmed/34070947
http://dx.doi.org/10.3390/v13061033
_version_ 1783713109650702336
author Tucciarone, Claudia Maria
Franzo, Giovanni
Legnardi, Matteo
Lazzaro, Elena
Zoia, Andrea
Petini, Matteo
Furlanello, Tommaso
Caldin, Marco
Cecchinato, Mattia
Drigo, Michele
author_facet Tucciarone, Claudia Maria
Franzo, Giovanni
Legnardi, Matteo
Lazzaro, Elena
Zoia, Andrea
Petini, Matteo
Furlanello, Tommaso
Caldin, Marco
Cecchinato, Mattia
Drigo, Michele
author_sort Tucciarone, Claudia Maria
collection PubMed
description Feline panleukopenia is a severe disease of cats caused by feline parvovirus (FPV), and marginally canine parvovirus (CPV). Despite being less rapid than CPV, FPV evolution deserves attention, especially since outbreaks of particular severity are currently reported. This apparently different virulence needs monitoring from genetic and clinical points of view. This manuscript explored FPV molecular epidemiology at both Italian and international levels and the possible association between viral phylogeny and disease severity. Sequences from clinical cases of feline panleukopenia in Italy were obtained from 2011 to 2019, and the etiological agent was characterized, distinguishing FPV from CPV. Phylogenetic and phylodynamic analyses were conducted on Italian and international sequences. Moreover, the association between the viral sequence and clinical variables was evaluated on a group of highly characterized patients. After its origin in the 1920s, FPV showed a constant population size until a more recent expansion since 2000. Few long-distance introduction events characterized FPV spreading, however, most of its evolution occurred locally. Although without a strong statistical association, several clinical variables appeared influenced by viral phylogeny, suggesting a differential virulence potentially characterizing FPV strains. These results stress the importance of the continuous study of viral evolution and its repercussions on the disease clinical aspects.
format Online
Article
Text
id pubmed-8230023
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82300232021-06-26 Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables Tucciarone, Claudia Maria Franzo, Giovanni Legnardi, Matteo Lazzaro, Elena Zoia, Andrea Petini, Matteo Furlanello, Tommaso Caldin, Marco Cecchinato, Mattia Drigo, Michele Viruses Article Feline panleukopenia is a severe disease of cats caused by feline parvovirus (FPV), and marginally canine parvovirus (CPV). Despite being less rapid than CPV, FPV evolution deserves attention, especially since outbreaks of particular severity are currently reported. This apparently different virulence needs monitoring from genetic and clinical points of view. This manuscript explored FPV molecular epidemiology at both Italian and international levels and the possible association between viral phylogeny and disease severity. Sequences from clinical cases of feline panleukopenia in Italy were obtained from 2011 to 2019, and the etiological agent was characterized, distinguishing FPV from CPV. Phylogenetic and phylodynamic analyses were conducted on Italian and international sequences. Moreover, the association between the viral sequence and clinical variables was evaluated on a group of highly characterized patients. After its origin in the 1920s, FPV showed a constant population size until a more recent expansion since 2000. Few long-distance introduction events characterized FPV spreading, however, most of its evolution occurred locally. Although without a strong statistical association, several clinical variables appeared influenced by viral phylogeny, suggesting a differential virulence potentially characterizing FPV strains. These results stress the importance of the continuous study of viral evolution and its repercussions on the disease clinical aspects. MDPI 2021-05-30 /pmc/articles/PMC8230023/ /pubmed/34070947 http://dx.doi.org/10.3390/v13061033 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tucciarone, Claudia Maria
Franzo, Giovanni
Legnardi, Matteo
Lazzaro, Elena
Zoia, Andrea
Petini, Matteo
Furlanello, Tommaso
Caldin, Marco
Cecchinato, Mattia
Drigo, Michele
Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables
title Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables
title_full Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables
title_fullStr Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables
title_full_unstemmed Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables
title_short Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables
title_sort genetic insights into feline parvovirus: evaluation of viral evolutionary patterns and association between phylogeny and clinical variables
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230023/
https://www.ncbi.nlm.nih.gov/pubmed/34070947
http://dx.doi.org/10.3390/v13061033
work_keys_str_mv AT tucciaroneclaudiamaria geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT franzogiovanni geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT legnardimatteo geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT lazzaroelena geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT zoiaandrea geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT petinimatteo geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT furlanellotommaso geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT caldinmarco geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT cecchinatomattia geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables
AT drigomichele geneticinsightsintofelineparvovirusevaluationofviralevolutionarypatternsandassociationbetweenphylogenyandclinicalvariables