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Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables
Feline panleukopenia is a severe disease of cats caused by feline parvovirus (FPV), and marginally canine parvovirus (CPV). Despite being less rapid than CPV, FPV evolution deserves attention, especially since outbreaks of particular severity are currently reported. This apparently different virulen...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230023/ https://www.ncbi.nlm.nih.gov/pubmed/34070947 http://dx.doi.org/10.3390/v13061033 |
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author | Tucciarone, Claudia Maria Franzo, Giovanni Legnardi, Matteo Lazzaro, Elena Zoia, Andrea Petini, Matteo Furlanello, Tommaso Caldin, Marco Cecchinato, Mattia Drigo, Michele |
author_facet | Tucciarone, Claudia Maria Franzo, Giovanni Legnardi, Matteo Lazzaro, Elena Zoia, Andrea Petini, Matteo Furlanello, Tommaso Caldin, Marco Cecchinato, Mattia Drigo, Michele |
author_sort | Tucciarone, Claudia Maria |
collection | PubMed |
description | Feline panleukopenia is a severe disease of cats caused by feline parvovirus (FPV), and marginally canine parvovirus (CPV). Despite being less rapid than CPV, FPV evolution deserves attention, especially since outbreaks of particular severity are currently reported. This apparently different virulence needs monitoring from genetic and clinical points of view. This manuscript explored FPV molecular epidemiology at both Italian and international levels and the possible association between viral phylogeny and disease severity. Sequences from clinical cases of feline panleukopenia in Italy were obtained from 2011 to 2019, and the etiological agent was characterized, distinguishing FPV from CPV. Phylogenetic and phylodynamic analyses were conducted on Italian and international sequences. Moreover, the association between the viral sequence and clinical variables was evaluated on a group of highly characterized patients. After its origin in the 1920s, FPV showed a constant population size until a more recent expansion since 2000. Few long-distance introduction events characterized FPV spreading, however, most of its evolution occurred locally. Although without a strong statistical association, several clinical variables appeared influenced by viral phylogeny, suggesting a differential virulence potentially characterizing FPV strains. These results stress the importance of the continuous study of viral evolution and its repercussions on the disease clinical aspects. |
format | Online Article Text |
id | pubmed-8230023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82300232021-06-26 Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables Tucciarone, Claudia Maria Franzo, Giovanni Legnardi, Matteo Lazzaro, Elena Zoia, Andrea Petini, Matteo Furlanello, Tommaso Caldin, Marco Cecchinato, Mattia Drigo, Michele Viruses Article Feline panleukopenia is a severe disease of cats caused by feline parvovirus (FPV), and marginally canine parvovirus (CPV). Despite being less rapid than CPV, FPV evolution deserves attention, especially since outbreaks of particular severity are currently reported. This apparently different virulence needs monitoring from genetic and clinical points of view. This manuscript explored FPV molecular epidemiology at both Italian and international levels and the possible association between viral phylogeny and disease severity. Sequences from clinical cases of feline panleukopenia in Italy were obtained from 2011 to 2019, and the etiological agent was characterized, distinguishing FPV from CPV. Phylogenetic and phylodynamic analyses were conducted on Italian and international sequences. Moreover, the association between the viral sequence and clinical variables was evaluated on a group of highly characterized patients. After its origin in the 1920s, FPV showed a constant population size until a more recent expansion since 2000. Few long-distance introduction events characterized FPV spreading, however, most of its evolution occurred locally. Although without a strong statistical association, several clinical variables appeared influenced by viral phylogeny, suggesting a differential virulence potentially characterizing FPV strains. These results stress the importance of the continuous study of viral evolution and its repercussions on the disease clinical aspects. MDPI 2021-05-30 /pmc/articles/PMC8230023/ /pubmed/34070947 http://dx.doi.org/10.3390/v13061033 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tucciarone, Claudia Maria Franzo, Giovanni Legnardi, Matteo Lazzaro, Elena Zoia, Andrea Petini, Matteo Furlanello, Tommaso Caldin, Marco Cecchinato, Mattia Drigo, Michele Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables |
title | Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables |
title_full | Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables |
title_fullStr | Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables |
title_full_unstemmed | Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables |
title_short | Genetic Insights into Feline Parvovirus: Evaluation of Viral Evolutionary Patterns and Association between Phylogeny and Clinical Variables |
title_sort | genetic insights into feline parvovirus: evaluation of viral evolutionary patterns and association between phylogeny and clinical variables |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230023/ https://www.ncbi.nlm.nih.gov/pubmed/34070947 http://dx.doi.org/10.3390/v13061033 |
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